This work clearly demonstrates the power of aptamer to differentiate the minor molecular difference between metastatic cancer cells and cancer cells of the same tissue origin of the same patient. It opens new possibilities in generating highly selective molecular probes for advanced molecular tools for cancer theranostics. Congratulations to all authors.
Li, X; An, Y; Jin, J; Zhu, Z; Hao, L; Liu, L, Shi, Y; Fang, D, Ji, T;
Yang, C*, Evolution of DNA Aptamers through in vitro Metastatic-cell-based SELEX for Metastatic Cancer Recognition and Imaging
,Anal Chem,2015,87, DOI: 10.1021/acs.analchem.5b00637.