Department of Chemical Biology
Yang's Lab,Department of Chemical Biology, Xiamen University
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Professor Yang

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Yang's Laboratory

Room 532, Lujiaxi Building, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China

Ph: +86 (0) 592-218 7601

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Investigator

  • Chaoyong James Yang

    杨朝勇
    Email: chaoyongyang@gmail.comcyyang@xmu.edu.cn
    Group Website: http://www.yang-lab.com/ & http://chem.xmu.edu.cn/teacher.asp?id=166
    Phone Number: 0592-2187601

    主要经历
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    • 2017年8月至今,上海交通大学医学院分子医学研究院,副院长
    • 2015年8月至今,谱学分析与仪器教育部重点实验室,副主任
    • 2010年11月至今,厦门大学药学院,兼职教授
    • 2008年 8月至2018年8月,厦门大学特聘教授
    • 2008年 1月至2018年8月,厦门大学化学生物学系,教授、博导
    • 2008年11月至今,固体表面物理化学国家重点实验室,固定成员
    • 2006年9月至2007年12月,加州大学伯克利分校化学系, 博士后, 导师: Richard Mathies
    • 2001年8月至2006年8月,美国佛罗里达大学,生物分析化学博士,导师: 谭蔚泓
    • 1994年9月至2001年7月,厦门大学化学系,本科,硕士,导师:王小如
     
    研究兴趣
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    • 1. 体外诊断新技术
    • 2. 细胞识别、富集与成像
    • 3. 高通量单细胞测序
    • 4. 微流控技术在生物医学中的应用
     
    学术任职
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    • 中国化学会化学生物学专业委员会副主任
    • 中国生物传感、生物芯片与纳米生物技术专业委员会委员
    • 美国化学会ACS Applied Bio Materials副主编、BMC Biochemistry副主编、Scientific Reports 编委、美 国化学会期刊Analytical Chemistry 顾问编委、英国皇家化学会期刊AnalystLab on a Chip顾问编委、美国物理联合会期刊Biomicrofluidics 顾问编委、Journal of Analysis and Testing编委、《分析化学》编委。
    • 厦门大学药学院、化学化工学院教授委员会委员
     
    获奖情况
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    • 第五届中国化学会-英国皇家化学会青年化学奖(2016)
    • 中组部、科技部等9部委《全民科学素质行动计划纲要》实施工作先进个人(2016)
    • 福建省自然科学优秀学术论文一等奖(2016年)
    • 科技部中青年科技创新领军人才(2015)
    • 中国青年分析化学家奖 (2015年)
    • 福建省青年科技奖 (2015)
    • 厦门市科学技术进步奖二等奖 (2015)
    • 福建省科技创新领军人才(2015)
    • 福建省自然科学优秀学术论文一等奖(2014年)
    • 福建省高校领军人才 (2014年)
    • 厦门大学田昭武学科交叉奖一等奖(2014)
    • 国家杰出青年科学基金(2013)
    • 第二十届福建省运盛青年科技奖(2013)
    • 第九届福建省五四青年奖章, (2012)
    • 中美化学与化学生物学教授协会“杰出教授奖”(2012)
    • 厦门大学“工商银行奖教金”(2011)
    • 福建省杰出青年基金(2010)
    • 2005年度中国国家优秀自费留学生奖 (2006)
    • 美国佛罗里达大学Stasch 论文发表奖 (2006, 2007)
    • 美国Sigma Xi 科研协会研究科研奖 (2006)
    • 美国佛罗里达大学O’Neil 博士论文奖(2005-2006)
    • 美国化学会分析化学研究生奖(2005)
    • 美国宝洁科研奖(2005)
    • 美国佛罗里达大学Herbert A. and Marjorie G. Laitinen 研究生奖(2005)
    • 福建省优秀三好学生(2000)
    • 厦门大学光华奖学金(1999, 2000)
    • 厦门大学优秀三好学生、优秀学生干部(1997, 1998, 1999)
    • 厦门大学化学化工学院傅鹰奖学金(1998)
    • 厦门大学奖学金, (1995-1998)
    • 福建省庄采芳奖学金(1994)
     
    承担主要科研项目
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    • 国家自然科学基金委重点项目,21735004 ,循环肿瘤细胞高效分型捕获与高通量单细胞转录组测序分析,2018年01月 至2022年12月,300万,在研,主持。
    • 国家自然科学基金委杰出青年基金,21325522,生物分析化学,2014/01-2017/12,320万,在研,结题(优秀)
    • 国家自然科学基金委重大研究计划集成项,91313302,基于化学小分子探针的信号转导过程研究,2014/01-2015/12,  120万,已结题,参加
    • 国家基金委面上项目,21275122, 核酸适体功能化微流控芯片用于循环肿瘤细胞的捕获富集检测, 2013/01-2016/12,80万,在研,已结题
    • 国家基金委面上项目,21075104, 液滴微流控技术用于高通量单细胞分析,2011/01-2013/12,37万,已结题,主持
    • 科技部973课题,2010CB732402,核酸适体分子识别体系的设计与生物标志物的甄定,2010/01-2014/12,560万,已结题,主持
    • 国家基金委青年基金,20805038, 用于细胞内基因成像的新型分子信标的设计与合成,2009/01-2011/12,22万,已结题,主持
    • 教育部高博士学点基金(博导类), 外周血循环肿瘤细胞的识别、富集及单细胞水平表征新方法,2014-16年, 已结题,主持
    • 科技部国家重大科学仪器设备开发专项,等离激元增强拉曼光谱仪器研发与应用,2011-10-01-2015-09- 30,已结题,主持
    • 科技部973课题,增强拉曼光谱、电化学及联用技术应用于单细胞实时研究,2007-2011,已结题,主持
    • 教育部留学回国人员科研启动基金,用于活细胞内mRNA成像的分子探针,2008-2010,已结题,主持
    • 福建省自然科学基金,肿瘤干细胞的适体筛选及其在癌症研究和治疗的应用,2008-10年,已结题,主持
    • 教育部博士点新教师基金,高通量单细胞基因分析的液滴微流控技术,2009-11年,已结题,主持
    • 福建省杰出青年基金,肿瘤的早期诊断新方法研究,2010.6.1-2013.5.31已结题,主持
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    发表论文Research ID: F-9741-2010, http://orcid.org/0000-0002-2374-5342共发表SCI论文153篇,论文被引6800余次,  H index=43, 以第1作者或通讯作者发表SCI影响因子> 5.0的论文 79篇,  其中PNAS1 篇、Acc. Chem. Res.1篇、JACS  5 篇、Angew Chemie10 篇、AC19篇、Lab Chip6 篇、CC  13篇。
     
     
    2018
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    • 156. Song, yanling; Lin, Bingqian; Tian, Tian; Xu, Xing; Wang, Wei; Ruan, Qingyu Amos; Guo, Jingjing; Zhu, Zhi; Yang, Chaoyong, Recent Progress in Microfluidics-based Biosensing,  Analytical Chemistry, ac-2018-05007p.R1
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    • 155. A tridecaptin-based fluorescent probe for differential staining of Gram-negative bacteria. DOI : 10.1007/s00216-018-1465-0
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    • 154. Fenxiang Zou†a, Qingyu Ruan†a, Xiaoye Lina, Mingxia Zhanga, Yanling Songb, Leiji Zhoua, Zhi Zhua, Shuichao Lina, Wei Wangb, Chaoyong James Yanga,b Rapid, Real-Time Chemiluminescent Detection of DNA Mutation Based on Digital Microfluidics and Pyrosequencing.  Biosensors and Bioelectronics DOI : https://doi.org/10.1016/j.bios.2018.09.092
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    • 153. Zhang, H; Yang, Y; Li, X; Shi, Y; Hu, B; An, Y; Zhu, Z; Hong, G; Yang, C*, Frequency-Enhanced Transferrin receptor Antibody-Labelled Microfluidic Chip (FETAL-Chip) enables efficient enrichment of circulating nucleated red blood cells for non-invasive prenatal diagnosis, Lab Chip, 2018, DOI: 10.1039/c8lc00650d
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    • 152. Ma, Y; Lv, Z; Li, T; Tian, T; Lu, L; Liu, W; Y; Zhu, Z; Yang, C*, Design and Synthesis of ortho-Phthalaldehyde Phosphoramidite for Single-step, Rapid, Efficient and Chemoseletive Coupling of DNA with Proteins under Physiological Conditions, Chem Comm, 2018,54, 9434 - 9437
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    • 151. Chen, Y; Ke, G*; Ma, Y; Zhu, Z; Liu, M; Liu, Y; Yan, H*; Yang, C*, A Synthetic Light-Driven Substrate Channeling System for Precise Regulation of Enzyme Cascade Activity Based on DNA Origami, J. Am. Chem. Soc., 2018,28, 8990-8996
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    • 150. Tian, T; Bi, Y; Xu, X; Zhu, Z; Yang, C*, Integrated paper-based microfluidic devices for point-of-care testing, Anal. Methods, 2018, 10, 3567 - 3581
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    • 149. Wu, Q; Wang, Y; Wang, H; Wu, L; Zhang, H; Song, Y; Zhu, Z; Kang, D*; Yang, C*. DNA aptamers from whole-cell SELEX as new diagnostic agents against glioblastoma multiforme cells. Analyst,2018, 10, 2267-2275
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    • 148. Shi, L; Lei, J; Zhang, B; Li, B; Yang, C; Jin Y*, Ultrasensitive and Facile Detection of MicroRNA via a Portable Pressure Meter., ACS Appl Mater Interfaces.2018, 10, 12526-12533
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    • 147. Li, J; Liu, F; Zhu, Z; Liu, D; Chen, X; Song, Y; Zhou, L; Yang, C*,An in situ Pt Staining Method for Simple, Stable, and Sensitive Pressure-based Bioassays,ACS Appl Mater Interfaces,2018, 10, 13390-13396
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    • 146. Wang, Y; Ruan, Q; Lei, Z; Lin, S; Zhu, Z; Zhou, L; Yang, C*,Highly Sensitive and Automated SERS-based Immunoassay for H5N1 Detection with Digital Microfluidics,Anal Chem, 2018, 90, 5224-5231
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    • 145. Lin, B;Guan, Z;Song, Y;Song, E;Lu, Z; Liu, D; An, Y; Zhu, Z; Zhou, L;Yang, C*,Lateral Flow Assay with Pressure Meter Readout for Rapid Point-of-care Detection of Disease-associated Protein,Lab Chip, 2018,18, 965-970
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    • 144. Liu, D; Tian, T; Chen, X; Lei, Z; Song, Y; Shi, Y; Ji, T; Zhu, Z; Yang, L*; Yang, C*,Gas-generation Reaction for Point-of-Care Testing,Analyst, 2018,143,1294-1304
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    • 143. Ma, Y; Mao, Y; An, Y; Tian, T; Zhang, H; Yan, J; Zhu, Z*;Yang, C*,Target-Responsive DNA Hydrogel for Non-enzymatic and Visual Detection of Glucose,Analyst, 2018, 143, 1679-1684
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    • 142. Li X; Zhang D; Zhang H; Guan Z; Song Y; Liu R; Zhu, Z*;Yang, C,A Microwell Array Method for Rapid Generation of Uniform Agarose Droplets and Beads for Single Molecule Analysis,Anal Chem, 2018,90, 2570-2577
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    • 141. Tan, Y; Liu, W; Zhu, Z*; Lang, L; Wang, J; Huang, M; Zhang, M; Yang, C*,Selection and identification of transferrin receptor-specific peptides as recognition probes for cancer cells.Anal Bioanal Chem, 2018,410, 1071-1077
     

    2017
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    • 140. Song, Y; An, Y; Liu, W; Hou, W; Li, X; Lin, B; Zhu, Z; Ge, S*; Yang, H*; Yang, C*,Centrifugal Micropipette-Tip with Pressure Signal Readout for Portable Quantitative Detection of Myoglobin, Chem Commun., 2017, 53, 11774-11777
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    • 139. Gao, M; Guo, J; Song, Y*; Zhu, Z*; Yang, C*, Detection of T4 Polynucleotide Kinase via Allosteric Aptamer Probe Platform,ACS Appl. Mater. Interfaces, 2017,9, 38356-38363
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    • 138. Tian T, An Y, Wu Y, Song Y*, Zhu Z, Yang, C*, Integrated Distance-Based Origami Paper Analytical Device for One-Step Visualized Analysis, ACS Appl Mater Interfaces.2017, 9, 30480-30487
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    • 137. Gashaw, M; Abate, M; Song, Y; Zhu, Z; Yan, F; Xu, Y; Wang, X; Li, Q; Yang, C*. Isolation, Detection and Antigen Based Profiling of Circulating Tumor Cells Using a Size Dictated Immunocapture Chip, Angew. Chem. Int. Ed., 2017, 56, 10681-10685
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    • 136. Wang, Y; Yang, L; Li, B, Yang, C; Jin, Y*. Point-of-care assay of telomerase activity at single-cell level via gas pressure readout, Anal. Chem., 2017, 89, 8311-8318
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    • 135. Liu, D; Jia, S; Zhang, H; Ma, Y; Guan, Z; Li, J; Zhu, Z*; Ji, T; Yang, C*. Integrating Target-Responsive Hydrogel with Pressuremeter Readout Enables Simple, Sensitive, User-friendly, Quantitative Point-of-Care Testing, ACS Appl. Mater. Interfaces, 2017,9, 22252-22258
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    • 134. Mao, Y; Li, J; Yan, J; Ma, Y; Song, Y; Tian, T; Liu, X; Zhu, Z; Zhou, L*; Yang, C.A Portable Visual Detection Method Based on Target-responsive DNA Hydrogel and Color Change of Gold Nanorods, Chem Commun., 2017, 53, 6375 – 6378
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    • 133. Huang Y, Wu, X; Tian, T; Zhu,Z; Yang C., Target-responsive DNAzyme hydrogel for portable colorimetric detection of lanthanide(III) ions, Science China-Chemistry, 2017, 60, 293-298
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    • 132. Liu, D; Li, X; Zhou, J; Liu, S; Tian, T; Song, Y; Zhu, Z; Zhou, L; Ji, T; Yang, C*. A Fully Integrated Distance Readout ELISA-Chip for Point-of-Care Testing with Sample-in-Answer-out Capability,Biosens Bioelectron, 2017, 96, 332-338
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    • 131. Zhu, Z; Yang, C*. Hydrogel Droplet Microfluidics for High-throughput Single Molecule/Cell Analysis,Acc. Chem. Res.,2017,50, 22-31
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    • 130. Song, Y; Tian, T; Shi, Y; Liu, W; Zou, Y, Khajavand, T; Zhu, Z; Yang, C*. Enrichment and Single-Cell Analysis of Circulating Tumor Cells, Chem. Sci.,2017, 8, 1736-1751


    2016
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    • 129. Xie, Y; Wei, X; Yang, Q; Guan, Z; Liu, Dan; Liu, X; Zhou, L; Zhu, Z*; Lin, Z; Yang, C*. Shake&Read Distance-based Microfluidic Chip as a Portable Quantitative Readout Device for Highly Sensitive Point-of-Care Testing, Chem Commun., 2016, 52, 13377-13380
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    • 128. Song,Y; Shi, Y; Li, X; Ma, Y; Gao, M; Liu, D, Mao, Y, Zhu, Z; Yang, C*.Afi-Chip: An Equipment-free, Low-cost and Universal Binding Ligand Affinity Evaluation Platform, Anal. Chem., 2016, 88, 8294-8301
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    • 127. Li J; Zhu, Z; F, Liu; Zhu, B; Y, Ma; J, Yan; B, Lin; G, Ke; R, Liu; L, Zhou; Tu, S; Yang, C*. DNA-MediatedMorphological Control of Silver Nanoparticles, Small, 2016, 12, 5449-5457
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    • 126.  Li, J; Zhu, Z; Zhu, B; Ma, Y; Lin, B; Liu, R; Song, Y; Lin, H; Tu, S; Yang, C*, SERS-active Plasmonic Nanoparticles with Ultra-small Interior Nanogap for Multiplex Quantitative Detection and Cancer Cell Imaging, Anal Chem 2016, 88, 7828-7836
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    • 125. Ma, Y; Mao, Y; Huang, D; He, Z; Yan, J; Tian, T; Shi, Y; Song, Y; Li, X; Zhu*, Z; Zhou, L; Yang, C. Portable Visual Quantitative Detection of Aflatoxin B1 Using a Target-Responsive Hydrogel and Distance-Readout Microfluidic Chip. Lab on a Chip,2016 16, 3097-3104
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    • 124.  Ji, T; Liu, D; Liu, F; Li, J; Ruan, Q; Song, Y; Tian, T; Zhu, Z; Zhou, L; Lin, H*; Yang, C; Wang, D*. A pressure-based bioassay for the rapid, portable and quantitative detection of C-reactive protein.Chem Commun, 2016,52, 8452-8454
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    • 123. Zhang, H; Zhou, L; Zhu, Z; Yang, C*. Recent Progress in Aptamer-based Functional Probes for Bioanalysis and Biomedicine, Chem.-Eur. J.,2016, 22, 9886-9900
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    • 122. Huang, Y; Fang, L; Zhu, Z; Ma, Y; Zhou, L; Chen, X; Xu, D; Yang, C*. Design and synthesis of target-responsive hydrogel for portable visual quantitative detection of uranium with a microfluidic distance-based readout device.Biosens Bioelectron 2016,85, 496-502
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    • 121. Ke, G; Liu, M; Jiang, S; Qi, X; Yang, YR; Wootten, S; Zhang, F; Zhu, Z; Liu, Y; Yang, C*; Yan, H*. Directional Regulation of Enzyme Pathways through the Control of Substrate Channeling on a DNA Origami Scaffold. Angew Chem Int Ed 2016, 55,7483-7486
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    • 120. Wang, K; Wu, D; Chen, Z; Zhang, X; Yang, X; Yang, C*; Lan, X*. Inhibition of The Superantigenic Activities of Staphylococcal Enterotoxin A by an Aptamer Antagonist. Toxicon. 2016,119, 21-27
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    • 119. Chen, L*; Gong, L; Lin, Y; Jin, X; Li, H; Li, S; Che, K; Cai, Z; Yang, C. Microfluidic Fabrication of Cholesteric Liquid Crystal Core-Shell Structures Toward Magnetically Transportable Microlasers.Lab Chip, 2016,16, 1206-1613
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    • 118. Tian, T; Li, J; Song, Y; Zhou, L; Zhu, Z*; Yang, C*. Distance-based Microfluidic Quantitative Detection Methods for Point-of-Care Testing.  Lab Chip, 2016, 16, 1139-1151
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    • 117. Lin, B; Liu, D;Yan, J; Qiao, Z; Zhong, Y; Yan, J; Zhu, Z; Ji, T; Yang, C*. Enzyme Encapsulated Liposome-Linked Immunosorbent Assay Enabling Sensitive Personal Glucose Meter Readout for Portable Detection of Disease Biomarkers, ACS Appl. Mater. Interfaces, 2016, 8, 6890-6897.
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    • 116. Wei, X; Tian, T; Jia, S; Zhu, Z; Ma, Y; Sun, J; Lin, Z*; Yang, C*. Microfluidic Distance Readout Sweet Hydrogel Integrated Paper-based Analytical Device (μDiSH-PAD) for Visual Quantitative Point-of-Care Testing. Anal Chem 2016, 88, 2345-2352
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    • 115. Wu, Q; Wu, L; Wang, Y; Zhu, Z; Song, Y; Tan, Y; Wang, X; Li, J; Kang, D*; Yang C*. Evolution of DNA Aptamers for Malignant Brain Tumor Gliosarcoma Cell Recognition and Clinical Tissue Imaging,Biosensors & Bioelectronics, 2016, ;80, 1-8
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    • 114. Tian, T; Wei, X; Jia, S; Zhang, R; Li, J; Zhu, Z*; Zhang, H; Ma, Y; Lin, Z; Yang, C*. Integration of Target Responsive Hydrogel with Cascaded Enzymatic Reactions and Microfluidic Paper-based Analytic Devices (microPADs) for Point-of-Care Testing (POCT). Biosens Bioelectron2016, 77, 537-542.
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    • 113. Zhang, W; Zu, X; Song, Y; Zhu, Z*; Yang, C*. Detection of DNA Methyltransferase Activity Using Allosteric Molecular Beacons. Analyst, 2016, 141, 579-584
     

    2015
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    • 112. Cui, L; Peng, RR; Fu, T; Zhang, XB*; Wu, C; Chen, H; Liang, H; Yang, C; Tan W*. Biostable L-DNAzyme for Sensing of Metal Ions in Biological Systems. Anal Chem, 2015, 88, 1850-1857
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    • 111. An, Y; Wu, J; Yang, B; Zhu, Z; Gao, M; Yu, C*; Yang, C*. Selection and Application of DNA Aptamer Against Oncogene Amplified in Breast Cancer 1. J Molecular Evolution2015, 81,179-185
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    • 110. Liu, Z; Lu, Y; Pu, Y; Liu, J; Liu, B; Yu, B; Chen, K; Fu, T; Yang, C; Liu, H*; Tan, W*. Using Aptamers to Elucidate Esophageal Cancer Clinical Samples,Sci Rep, 2015, 5, 18516.
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    • 109. Zhu, Z; Guan, Z; Liu, D; Jia, S; Li, J; Lei, Z; Lin, S; Ji, T; Tian, Z; Yang, C*. Translating Molecular Recognition into Pressure Signal for Rapid, Sensitive, and Portable Biomedical Analysis, Angew Chem Int Ed., 2015, 54, 10448-10453
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    • 108. Li, J; Zhu, B; Zhu, Z; Zhang, Y; Yao, X; Tu, S*; Liu, R; Jia, S; Yang, C*. Simple and Rapid Functionalization of Gold Nanorods with Oligonucleotides using an mPEG-SH/Tween 20-Assisted Approach,Langmuir, 2015,31, 7869-7876
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    • 107. Tian, T; Huang, Y; Lin, B; Wei, X; Zhou, L; Yang, C*. Developments and Applications of Paper-Based Microfluidics, Journal of Instrumental Analysis (Chinese), 2015, 34, 257-267
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    • 106. Li, X; An, Y; Jin, J; Zhu, Z; Hao, L; Liu, L, Shi, Y; Fang, D, Ji, T; Yang, C*. Evolution of DNA Aptamers through in vitro Metastatic-cell-based SELEX for Metastatic Cancer Recognition and Imaging,Anal Chem,2015,87, 4941-4948
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    • 105. Xu, L; Lei, Z; Li, J; Zong, C; Yang, C; Ren, B*. Label-free Surface-enhanced Raman Spectroscopy Detection of DNA with Single-base Sensitivity, J.Am. Chem. Soc.,2015, 137, 5149-5154
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    • 104. Wei, X; Tian, T; Jia, S; Zhu, Z; Ma, Y; Sun, J; Lin, Z*; Yang, C*. Target-Responsive DNA Hydrogel Mediated “Stop-Flow” Microfluidic Paper-Based Analytic Device for Rapid,Portable and Visual Detection of Multiple Targets"Anal Chem. 2015, 87, 4275-4282
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    • 103. Zhang, H; Ma, Y; Xie, Y; An, Y; Huang, Y; Zhu, Z; Yang, C*. A Controllable Aptamer-Based Self-Assembled DNA Dendrimer for High Affinity Targeting, Bioimaging and Drug Delivery, Sci. Rep., 2015,5, 10099
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    • 102. Lin, Y; Liu, Y; Fan, C; Zheng, H; Li, Y; Zhang, C; Wu, S; Yu, D; Huang, Z; Liu, F; Luo, Q; Yang, C; Ouyang, G*. MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1, Sci. Rep., 2015, 5, 9995
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    • 101. Pu, Y; Liu, Z; Lu, Y; Yuan, P; Liu, J; Yu, B; Wang, G; Yang, C; Liu, H*; Tan, W*. Using DNA Aptamer Probe for Immunostaining of Cancer Frozen Tissues, Anal Chem. 2015, 87, 1919-1924
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    • 100. Liu, R; Huang, Y; Ma, Y; Jia, S; Gao, M; Li, J; Zhang, H; Xu, D; Wu, M; Chen, Y; Zhu, Z*; Yang, C*. Design and Synthesis of Target-Responsive Aptamer-Crosslinked Hydrogel for Visual Quantitative Detection of Ochratoxin A, ACS Appl. Mat. Interfaces. 2015, 7, 6982-6990
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    • 99. Xie, Y; Lin, X; Huang,Y; Pan, R; Zhu, Z; Zhou, L*; Yang, C*. Highly Sensitive and Selective Detection of miRNA: DNase I-Assisted Target Recycling using DNA Probes Protected by Polydopamine Nanospheres, Chem Commun, 2015,51,2156-2158
     

    2014
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    • 98. Huang, Y; Ma, Y; Chen, Y; Wu, X; Fang, L; Zhu, Z; Yang, C*. Target-Responsive DNAzyme Crosslinked Hydrogel for Visual Quantitative Detection of Lead, Anal Chem, 2014,86, 11434-11439
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    • 97. Wang, D; Song, Y; Zhu, Z; Li, X; Zou, Y; Yang, H; Wang, J; Yao, P; Pan, R; Yang, C*; Kang, D. Selection of DNA Aptamers against Epidermal Growth Factor Receptor with High Affinity and Specificity, Biochem and Biophysic Res Commun, 2014, 453, 681-685
    •  
    • 96. Li, J; Zhu, B, Yao, X; Zhang, Y; Zhu, Z; Tu, S; Jia, S, Liu, R; Kang, H*; Yang, C*. A Synergetic Approach for Simple and Rapid Conjugation of Gold Nanoparticles with Oligonucleotides,ACS Appl. Mat. Interfaces, 2014,6, 16800-16807
    •  
    • 95. Ke, G; Zhu, Z*; Wang, W; Zou, Y; Guan, Z; Jia S; Zhang, H; Wu, X; Yang, C*; A Cell Surface-anchored Ratiometric Fluorescent Probe for Extracellular pH Sensing, ACS Appl. Mat. Interfaces, 2014,6, 15329-15334
    •  
    • 94. Lin, C; Chen, Y; Cai, Z; Zhu, Z; Jiang, Y; Yang, C*; Chen, X*; A Label-free Fluorescence Strategy for Sensitive Detection of ATP Based on the Ligation-Triggered Super-Sandwich.Biosens Bioelectron. 2014, 63, 562-565
    •  
    • 93. Lin, C; Cai, Z; Wang, Y; Zhu Z; Yang, C*; Chen, X*; Label-Free Fluorescence Strategy for Sensitive Detection of Adenosine Triphosphate Using a Loop DNA Probe with Low Background Noise,Anal Chem,2014, 86, 6758-62
    •  
    • 92. Wang, R; Wang, C; Cao, Y; Zhu, Z; Yang, C; Chen, J; Qing, F; Tan, W*; Trifluoromethylated Nucleic Acid Analogues Capable of Self-Assembly through Hydrophobic Interactions, Chem Science, 2014, 5, 4076-4081
    •  
    • 91. Zhu Z; Guan, Z; Jia S; Lei Z; Lin, S; Zhang, H; Ma, Y; Tian, Z; Yang, C*; Au@Pt Nanoparticle Encapsulated Target-responsive Hydrogel with Volumetric Bar-chart Chip Readout for Quantitative Point-of-care Testing,Angew. Chem. Int. Ed., 2014, 53, 12503-12507
    •  
    • 90. Lin, H; Zhang, W; Jia, S; Guan, Z; Yang, C; Zhu, Z*; Microfluidic Approaches to Rapid and Efficient Aptamer Selection, Biomicrofluidics, 2014, 50, 7646-7648
    •  
    • 89. Tan, J; Ding, L; Ju, H*; Yang, Y; Li, X; Shen, Z; Zhu, Z; Yu, J*; Yang, C*; A Multifunctional Nanomicelle for Real-Time Targeted Imaging and Precise Near-Infrared Therapy of Cancer,Angew. Chem. Int. Ed., 2014,53, 9544-9549
    •  
    • 88. Cai, Z; Chen, Y; Lin C; Wu, Y; Yang, C*; Wang, Y; Chen, X*; A Dual-Signal Amplification Method for the DNA Detection Based on Exonuclease III,Biosens Bioelectron., 2014,60, 370-373
    •  
    • 87. Li, X; Zhang, W; Liu, L; Zhu, Z; Ouyang, G; An, Y; Zhao, C; Yang, C*, In Vitro Selection of DNA Aptamersfor Metastatic Breast Cancer Cell Recognition and Tissue Imaging,Anal Chem,2014,86, 6596-6603
    •  
    • 86. Zhu, Z; Song, Y; Li, C; Zou, Y; Zhu, L; An, Y; Yang, C*. Monoclonal Surface Display SELEX for Simple, Rapid, Efficient and Cost-Effective Aptamer Enrichment and Identification, Anal Chem, 2014,86, 5881-5888
    •  
    • 85. Lin, X; Cui, L; Huang, Y; Lin, Y; Xie, Y; Zhu, Z*; Chen, X; Yang, C*; Carbon Nanoparticle-Protected Aptamers for Highly Sensitive and Selective Detection of Biomolecules based on Nuclease-assisted Target Recycling Signal Amplification, Chem Commun, 2014,50, 7646-7648
    •  
    • 84. Zhang, H; Song, Y; Zou, Y; Ge, Y; An, Y; Ma, Y; Zhu, Z*;Yang, C*; A Diazirine-Based Photoaffinity Probe for Facile and Efficient Aptamer-Protein Covalent Conjugation, Chem. Commun., 2014, 50, 4891-4894
    •  
    • 83. Guan, Z; Zou, Y; Zhang, M; Li, J; Shen, H; Yang, P; Zhang, H; Zhu, Z; Yang, C*; A Highly Parallel Microfluidic Droplet Method Enabling Single-Molecule Counting for Digital Enzyme Detection, Biomicrofluidics, 2014, 8, 014110
    •  
    • 82. Guan, Z; Jia, S; Zhu, Z; Zhang, M; Yang, C*, Facile and Rapid Generation of Large-scale Micro-collagen-gel Array for Long-term Single Cell 3D Culture and Cell Proliferation Heterogeneity Analysis,Anal Chem, 2014, 86, 2789-2797
    •  
    • 81. Liu, D; Lin B; Shao, W; Zhu, Z; Ji, T*;Yang, C*, In Vitro and in Vivo Studies on the Transport of PEGylated Silica Nanoparticles across the Blood Brain Barrier, ACS Appl. Mat. Interfaces, 2014,6, 2131-2136
    •  
    • 80. Cui, L; Zhu, Z; Lin, L; Zhang, H; Guan, Z; Yang, C*, Exonuclease-Assisted Cyclic Enzymatic Amplification Method Coupled with Rolling Circle Amplification: A Dual-amplification Strategy for Sensitive and Selective MicroRNA Detection. Chem. Commun., 2014, 50, 1576-1578
     
     
    2013
    ——————————————————————————————————————————
    • 79. Luo, Y; Yan, X; Huang, Y; Wen, R; Li, Z; Yang, L; Yang, C; Wang, Q*, ICP-MS-Based Multiplex and Ultrasensitive Assay of Viruses with Lanthanide-Coded Biospecific Tagging and Amplification Strategies, Anal Chem, 2013, 85, 9428-9432
    •  
    •  78. Zou, Y; Chen, J; Zhu, Z; Lu, L; Huang, Y; Song, Y; Zhang, H; Kang, H; Yang, C*. Single-Molecule Photon-Fueled DNA Nanoscissors for DNA Cleavage based on the Regulation of Substrate Binding Affinity by Azobenzene,Chem. Commun., 2013,49, 8716-8718
    •  
    • 77. Wu, C; Chen, T; Han, D; You, M; Peng, L; Cansiz, S; Zhu, G; Li, C; Xiong, X; Jimene, E; Yang, C; Tan, W*; Engineering of Switchable Aptamer Micelle Flares for Molecular Imaging in Living Cells, ACS Nano, 2013,7, 5724-5731.
    •  
    • 76. Cui, L; Ke, G; Lin, X; Song, Y; Zhang, H; Guan, Z; Zhu, Z*; Yang, C. “Cyclic Enzymatic Amplification Method (CEAM) Based on Exonuclease III for Highly Sensitive Bioanalysis.” Methods, 2013, 63,202-211
    •  
    • 75. Lin, X; Zhang, C; Huang, Y; Zhu, Z*; Chen, X; Yang, C*.Backbone-Modified Molecular Beacons for Highly Sensitive and Selective Detection of MicroRNA Based on Duplex Specific Nuclease Signal Amplification,Chem. Commun.,2013, 49, 7243-7245
    •  
    • 74. Cui, L; Song, Y; Ke, G; Guan, Z; Zhang, H; Lin, Y; Huang, Y; Zhu, Z*; Yang, C*; Graphene Oxide-Protected Nucleic Acid Probes for Bioanalysis and Biomedicine, Chem.-Eur. J.,2013, 19, 10442-10451
    •  
    • 73. Song, Y; Zhu, Z*; An, Y; Zhang, W; Zhang, H; Liu, D; Yu, C; Duan, W*; Yang, C*;Selection of DNA Aptamers against Epithelial Cell Adhesion Molecule for Cancer Cell Imaging and Circulating Tumor Cell Capture, Anal Chem,2013, 85, 4141-4149
    •  
    • 72. Yan, L; Zhu, Z; Zou, Y; Huang, Y; Liu, D; Jia, S; Xu, D; Wu, M; Zhou, Y; Zhou, S; Yang, C*, Target-responsive “Sweet” Hydrogel with Glucometer Readout: an Effective Method for Portable and Quantitative Detection of Non-glucose Targets, J. Am. Chem. Soc., 2013,135, 3748-3751(Cover, Highlighted by JACS Spotlights)
    •  
    • 71. Cui, L; Chen, Z; Zhu, Z; Lin, X; Chen, X; Yang, C*. Stabilization of ssRNA on Graphene Oxide Surface: An Effective Way to Design Highly Robust RNA Probes,Anal Chem,2013,85, 2269-2275
    •  
    • 70. Xiong, X; Liu, H; Zhao, Z; Altman, M; Lopez-Colon, D; Yang, C*, Chang, L; Liu, C; Tan, W*.DNA Aptamer-mediated Cell Targeting, Angew. Chem. Int. Ed Engl., 2013,53, 1472-1476
    •  
    • 69. Cai, Z; Song, Y; Wu, Y; Zhu, Z; Yang, C; Chen, X*. An Electrochemical Sensor Based on Label-Free Functional Allosteric Molecular Beacons for Detection Target DNA/miRNA. Biosens Bioelectron., 2013,41, 783-788.

     
     
    2012
    ——————————————————————————————————————————
    • 68. Zhu, L; Li, C; Zhu, Z; Zou, Y; Fu, H; Wang, C; Yang, C*, In Vitro Selection of Highly Efficient G-Quadruplex-Based DNAzymes, Anal Chem,2012,84, 8383-8390
    •  
    • 67. Ke, G; Wang, C; Ge Y; Zheng, N; Zhu Z; Yang, C*, L-DNA Molecular Beacons: A Safe, Stable, and Accurate Intracellular Nano-thermometer for Temperature Sensing in Living Cells,J. Am. Chem. Soc., 2012,134, 18908-18911
    •  
    • 66. Wu, J; Wang, C; Li, X; Song, Y; Wang, W; Li, C; Hu, J; Zhu Z*; Zhang, W; Lu Z*; Yang, C*. Identification, Characterization and Application of a G-quadruplex Structured DNA Aptamer against Cancer Biomarker Protein Anterior Gradient Homolog 2, PLoS ONE, 2012,7, e46393
    •  
    • 65. Zhao, X; Wu, J; Liang, J; Yan, J; Zhu, Z; Yang, C*; Mao, B*. Single-Molecule Force Spectroscopic Studies on Intra- and Inter-Molecular Interactions of G-Quadruplex Aptamer with Target Shp2 Protein,J Physic Chem B, 2012,116, 11397-11404
    •  
    • 64. Zhou, T; Huang, Y; Li W; Cai, Z; Luo F; Yang, C*; Chen, X*. Facile Synthesis of Red-emitting Lysozyme-stabilized Ag Nanoclusters, Nanoscale 2012, 4, 5312-5315
    •  
    • 63. Kang, D*; Wang, J; Zhang, W; Zhu, M; Zhu, Z; Yang, C*.Selection of DNA Aptamers against Glioblastoma Cells with High Affinity and Specificity, PLoS ONE, 2012,7, e42731
    •  
    • 62. Li, C; Zhu, L; Zhu, Z; Fu, H; Jenkins, G; Wang, C; Zou, Y; Lu, X; Yang, C*. Backbone Modification Promotes Peroxidase Activity of G-Quadruplex-Based DNAzyme,Chem. Commun.,2012, 48, 8347-8349
    •  
    • 61. Zhu, Z; Zhang, W; Leng, X; Zhang, M; Guan, Z, Yang, C*. Highly Sensitive and Quantitative DetectionofRare Pathogen through Agarose Droplet Microfluidic Emulsion PCRat the Single-Cell Level,Lab Chip,2012, 12, 3907-3913
    •  
    • 60. Cui, L; Zou, Y; Lin, N; Zhu, Z; Jenkins, G; Yang, C*. Mass Amplifying Probe for Sensitive Fluorescence Anisotropy Detection of Small Molecules in Complex Biological Samples, Anal Chem,2012, 84, 5535-5541
    •  
    • 59. Zhang, H; Jenkins, G; Zou, Y; Zhu, Z; Yang, C*, Massively Parallel Single-Molecule and Single-Cell Emulsion Reverse Transcription Polymerase Chain Reaction Using Agarose Droplet Microfluidics, Anal Chem,2012, 84, 3599-3606
    •  
    • 58. Zhu, Z; Jenkins, G; Zhang,nW; Zhang, M; Guan, Z; Yang, C*. Single-Molecule Emulsion PCR in Microfluidic Droplet, Anal Bioanal Chem, 2012, 403, 2127-2143
    •  
    • 57. Zhang, W; Zhang, W; Liu, Z; Li, C; Zhu, Z; Yang, C*. A Highly Parallel Single Molecule Amplification Approach Based on Agarose Droplet PCR for Efficient and Cost-effective Aptamer Selection, Anal Chem,2012, 84, 350–355
    •  
    • 56. Song, Y; Zhang, W; An, Y; Cui, L; Chen, X; Zhu, Z*; Yang, C*.Label-Free Visual Detection of Nucleic Acids in Biological Samples with Single-Base Mismatch Detection Capability, Chem. Commun.,2012, 48, 576-578
    •  
    • 55. Cui, L; Lin, X; Lin, N; Song, Y; Zhu, Z; Chen, X; Yang, C*, Graphene Oxide -Protected DNA Probes for Multiplex MicroRNA Analysis in Complex Biological Samples Based on Cyclic Enzymatic Amplification Method,Chem. Commun.,2012,48, 194-196  (Inside Cover)
     
     
    2011
    —————————————————————————————————————————  
    • 54. Wang, X; Zhou, T, Song, X; Jiang, Y; Yang, C, Chen, X*; Chameleon Clothes for Quantitative Oxygen Imaging,J. Mater. Chem., 2011, 21, 17651
    •  
    • 53. Shigdar, S; Ward, A; De, A; Yang, C; Wei, M; Duan, W*, Clinical Applications of Aptamers and Nucleic Acid Therapeutics in Haematological Malignancies, British Journal of Haematology, 2011, 155, 3-13
    •  
    • 52. Tan, W*; Wang, H; Chen, Y; Zhang, X; Zhu, H; Yang, C; Yang, R., Molecular Aptamers for Drug Delivery, Trends in Biotechnology, 2011,12, 634-640
    •  
    • 51. Yang, C*; Cui, L; Huang, J; Yan, L; Lin, X; Wang, C; Zhang, W; Kang, H. Linear Molecular Beacons for Highly SensitiveBioanalysis Based on Cyclic Exo III EnzymaticAmplification,Biosens Bioelectron., 2011,27, 119-124
    •  
    •  
    • 50. Song, Y; Cui, L; Wu, J; Zhang, W; Kang, H; Yang, C*. Allosteric Molecular Beacons for Sensitive Detection of Nucleic Acids, Proteins and Small Molecules in Complex Biological Samples,Chem.-Eur. J.,2011,17, 9042-9046(Inside Cover)
    •  
    • 49. Lin, H; Zou, Y; Huang, Y; Chen, J; Zhang, W; Zhuang, Z; Jenkins, G; Yang, C*. DNAzyme Crosslinked Hydrogel: A New Platform for Visual Detection of Metal Ions,Chem. Commun.,2011, 47, 9312-9314. (Back Cover)
    •  
    • 48. Fang, X; Cai, Y; Liu, J; Wang, Z; Wu, Q; Zhang, Z; Yang, C; Yuan, L;Ouyang, G*. Twist2 Contributes to Breast Cancer Progression by Promoting anEpithelial-Mesenchymal Transition and Cancer Stem-Like CellSelf-renewal, Oncogene, 2011,30, 4707-4720
    •  
    • 47. Wang, K; You, M; Chen, Y; Han, D; Zhu, Z; Huang, J;Williams, K; Yang, C*; Tan, W*. Self-assembly of a Bifunctional DNA Carrier for Drug Delivery, Angew. Chem. Int. Ed Engl. 2011,50, 6098-6101
    •  
    • 46. Wang, X; Song, X; He, C; Yang, C; Chen, G; Chen, X*. Preparation of Reversible Colorimetric Temperature Nanosensors and Their Application in Quantitative Two-Dimensional Thermo-Imaging; Anal Chem., 2011, 83, 2434-2437
    •  
    • 45. Wang, C; Zhu, Z; Song, Y; Lin H; Yang C*; Tan, W*.Caged Molecular Beacons: Controlling Nucleic Acid Hybridizationwith Light, Chem. Commun.,2011,47, 5708-5710
    •  
    • 44. Hu, J; Wu, J; Li, C; Zhu, L; Zhang, W; Kong, G; Lu, Z*; Yang, C*. A G-quadruplex Aptamer Inhibits the Phosphatase Activity of Oncogenic Protein Shp2in vitro,ChemBioChem, 2011,12, 424-430
    •  
    • 43. Cui, L; Ke, G; Zhang, W; Yang, C*.  A Universal Platform for Sensitive and Selective Colorimetric DNA Detection Based on Exo III Assisted Signal Amplification, Biosens Bioelectron., 2011,26,2796-2800
    •  
    • 42. Huang, J; Wu, Y; Chen, Y; Zhu, Z; Yang, X; Yang, C*; Wang, K*; Tan, W*. Pyrene Excimer Probes for Nucleic Acids in Complex Biological Fluids Based on Hybridization Chain Reaction Amplification, Angew. Chem. Int. Ed Engl., 2011,50, 401-404
    •  
    • 41. Wang, C; Wu ,C; Chen, Y; Song, Y; Tan, W; Yang, C*.Pyrene Excimer for DNA Sensors, Current Organic Chemistry, 2011, 15, 465-476


    2010
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    • 40. Chen, Y; O'Donoghue, M; Huang, Y; Kang, H; Phillips, J; Chen, X; Estevez, M; Yang, C; Tan, W*. A Surface Energy Transfer Nanoruler for Measuring Binding Site Distances on Live Cell Surfaces, J. Am. Chem. Soc., 2010, 132, 16559-16570
    •  
    • 39. Li, D; Guan, Z; Zhang, W; Zhou, X; Zhuang, Z; Wang, X; Yang, C*. Synthesis of Uniform-size Hollow Silica Microspheres through Interfacial Polymerization in Monodisperse Water-in-oil Droplets, ACS Appl. Mat. Interfaces, 2010, 2, 2711-2713
    •  
    • 38. Wu, C; Hu, J; Zou, Y. A; Wang, C; Liu, J*; Yang, C*. Application of Aptamers in Biomedicine. Progress in Chemistry, 2010, 22, 1518-1530. (Invited Review)
    •  
    • 37. Ouyang, G*; Wang, Z; Fang, X; Yang, C. Molecular Signaling of the Epithelial to Mesenchymal Transition in Generating and Maintaining Cancer Stem Cells,Cellular and Molecular Life Sciences, 2010, 67, 2605-2618
    •  
    • 36. Leng, X; Zhang, W; Wang, C; Cui, L; Yang, C*. Agarose Droplet Microfluidics for Highly Parallel and EfficientSingle Molecule Emulsion PCR, Lab Chip 2010,10, 2841-2843. (Inside Cover),(Top Ten Accessed Paper, 2010 September)
    •  
    • 35. Cui, L; Ke, G; Wang, C; Yang, C*.ACyclic Enzymatic Amplification Method for Sensitive and Selective Detection of Nucleic Acids, Analyst., 2010, 135, 2069-2073
    •  
    • 34. Wu ,C; Yan, L; Wang, C; Wang, C; Chen, X; Yang, C*.A General Excimer Signaling Approach for Aptamer Sensors,Biosens Bioelectron., 2010, 25,2232-2237.
    •  
    • 33. Zhu, Z; Wu, C; Liu, H; Zou, Y; Zhang, X; Kang, H; Yang, C*; Tan, W*. Aptamer-Crosslinked Hydrogel as a Colorimetric Platform for Visual Detection. Angew. Chem. Int. Ed Engl. 201049, 1052-1056 (Frontipiece Paper)
    •  
    • 32. Yang, C;Tan, W.Understanding Bioanalytical Chemistry: Principles and Applications. By Victor A. Gault and Neville H. McClenaghan. ChemBioChem, 2010, 11, 434


    2009
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    • 31. Wu, C; Wang, C;Yan, L; Wang, C;Yang, C*.Pyrene Excimer Nucleic Acid Probes for Biomolecule Signaling.J.Biomed.Nanotech., 2009,5, 495-504
    •  
    • 30. Zhang, W; Lin, S; Wang, C; Hu, J; Li, C; Zhuang, Z; Zhou, Y; Mathies, R. A.*; Yang, C*. PMMA/PDMS Valves and Pumps for Disposable Microfluidics, Lab Chip, 2009, 9, 3088-3094
    •  
    • 29. Wang, K; Tang, Z; Yang, C; Kim, Y; Fang, X; Li, W; Wu, Y; Medley, C. D.; Cao, Z; Li, J; Colon, P; Lin, H; Tan, W*. Molecular Engineering of DNA: Molecular Beacons. Angew. Chem. Int. Ed Engl. 2009, 48, 856-870.


    2001-2008
    ——————————————————————————————————————————
    • 28. Martinez, K; Medley, C. D; Yang, C; Tan, W. Investigation of the Hybrid Molecular Probe for Intracellular Studies. Anal. Bioanal. Chem. 2008, 391, 983-991.
    •  
    • 27. Kumaresan, P; Yang, C; Cronier, S. A; Blazej, R. G; Mathies, R. A*. High-throughput Single Copy DNA Amplification and Cell Analysis in Engineered Nanoliter Droplets. Anal. Chem. 2008, 80, 3522-3529.Cover
    •  
    • 26. Wu, Y; Yang, C; Moroz, L. L; Tan, W*. Nucleic Acid Beacons for Long-term Real-time Intracellular Monitoring. Anal. Chem. 2008, 80, 3025-3028
    •  
    • 25. Chen, Y; Yang, C; Wu, Y; Conlon, P; Kim, Y; Lin, H; Tan, W*. Light-switching Excimer Beacon Assays for Ribonuclease H Kinetic Study.Chembiochem. 2008, 9, 355-359
    •  
    • 24. Conlon, P;Yang, C; Wu, Y; Chen, Y; Martinez, K; Kim, Y; Stevens, N; Marti, A. A; Jockusch, S; Turro, N. J.*; Tan, W*. Pyrene Excimer Signaling Molecular Beacons for Probing Nucleic Acids.J. Am. Chem. Soc. 2008, 130, 336-342
    •  
    • 23. Kim, Y; Yang, C; Tan, W*. Superior Structure Stability and Selectivity of Hairpin Nucleic Acid Probes with an L-DNA Stem. Nucleic Acids Res. 2007, 35, 7279-7287
    •  
    • 22. Yang, C; Wang, L; Wu, Y; Kim, Y; Medley, C. D; Lin, H; Tan, W*. Synthesis and Investigation of Deoxyribonucleic Acid/Locked Nucleic Acid Chimeric Molecular Beacons. Nucleic Acids Res. 2007, 35, 4030-4041
    •  
    • 21. Yang, C; Martinez, K; Lin, H; Tan, W*. Hybrid Molecular Probe for Nucleic Acid Analysis in Biological Samples. J. Am. Chem. Soc. 2006, 128, 9986-9987
    •  
    • 20. Shangguan, D; Li, Y; Tang, Z; Cao, Z; Chen, H; Mallikaratchy, P; Sefah, K; Yang, C; Tan, W*. Aptamers Evolved from Live Cells as Effective Molecular Probes for Cancer Study.Proc. Natl. Acad. Sci. U. S. A 2006, 103, 11838-11843
    •  
    • 19. Yang, C; Li, J; Tan, W*. Using Molecular Beacons for Sensitive Fluorescence Assays of the Enzymatic Cleavage of Nucleic Acids. Methods Mol. Biol. 2006, 335, 71-81
    •  
    • 18. Liu, H; Wang, H; Shi, Z; Wang, H; Yang, C; Silke, S; Tan, W; Lu, Z*. TaqMan probe array for quantitative detection of DNA targets. Nucleic Acids Res.2006, 34,Art. No. E4
    •  
    • 17. Tan, L; Li, Y; Drake, T; Moroz, L; Wang, K; Li, J; Munteanu, A; Yang, C; Martinez, K; Tan, W*. Molecular Beacons for Bioanalytical Applications. Analyst, 2005, 130,1002-1005
    •  
    • 16. Yang, C; Medley, C. D; Tan, W*. Monitoring Nucleic Acids using Molecular Beacons. Curr. Pharm. Biotechnol. 2005, 6, 445-452
    •  
    • 15. Yang, C; Jockusch, S; Vicens, M; Turro, N. J*; Tan, W*. Light-switching Excimer Probes for Rapid Protein Monitoring in Complex Biological Fluids. Proc. Natl. Acad. Sci. U. S. A, 2005, 102, 17278-17283
    •  
    • 14. Wang, L; Yang, C; Medley, C. D.; Benner, S. A; Tan, W*. Locked Nucleic Acid Molecular Beacons. J. Am. Chem. Soc. 2005, 127, 15664-15665.
    •  
    • 13. Yang, C;Lin, H; Tan, W*. Molecular Assembly of Superquenchers in Signaling Molecular Interactions. J. Am. Chem. Soc. 2005, 127, 12772-12773
    •  
    • 12. Yang, C;Pinto, M; Schanze, K; Tan, W*. Direct Synthesis of an Oligonucleotide-Poly(Phenylene Ethynylene) Conjugate with a Precise One-to-one Molecular Ratio.Angew. Chem. Int. Ed Engl. 2005, 44, 2572-2576
    •  
    • 11. Bagwe, R. P; Yang, C; Hilliard, L. R; Tan, W*. Optimization of Dye-doped Silica Nanoparticles Prepared using a Reverse Microemulsion Method.Langmuir 2004, 20, 8336-8342
    •  
    • 10. Wang, L; Yang, C; Tan, W*. Dual-luminophore-doped Silica Nanoparticles for Multiplexed Signaling. Nano Lett. 2005, 5, 37-43
    •  
    • 9. Huang, Z; Yang, C; Zhuang, Z; Wang, X*; Lee, F. S. C. Determination of Trace Lead in the High Salt Matrix of Comestible CaCO3 by an Isotope Dilution Method with Detection by Inductively Coupled Plasma-mass Spectrometry. Analytica Chimica Acta, 2004, 509, 77-82
    •  
    • 8. Yang, C; Huang, Z; Zhao, L; Zhuang, Z; Wang, X*. Isotope Dilution Inductively Coupled Plasma Mass Spectrometery for the Determination of Lead in Plants and Human hair. Chemical Journal of Chinese Universities-Chinese, 2002, 23, 1688-1691
    •  
    • 7. Wu, X; Sun, D; Yang, C; Zhuang, Z; Wang, X*. Speciation of 9 Trace Elements in a Traditional Chinese Medicine Long Dan Cao by Flow Injection-inductively Coupled Plasma Mass Spectrometry with a Focused Microwave Assisted Extraction System. Spectroscopy and Spectral Analysis, 2002, 22, 75-78
    •  
    • 6. Huang, H; Zhuang, Z; Zhang, W; Hu, J; Yang, C; Wang, X*. Application of Electrical Driven and Cationic Exchange Membrane to Capture and Enrich Deoxyribonucleic Acid. Chinese Journal of Analytical Chemistry 2010, 38, 143-146
    •  
    • 5. Yang, C;Wu, X; Gu, S; Zhuang, Z; Wang, X*. Hyphenation of C-18 Gel Silica Column and Flow Injection with Inductively Coupled Plasma-Mass Spectrometry and its Application on the Seawater Analysis. Chinese Journal of Analytical Chemistry, 2001, 29, 283-286
    •  
    • 4. Yang, C;Chen F; Zhuang, Z; Gu, S; Wang, X*. Determination of Trace Lead in High Salt-Containing Samples by Solid Phase Extraction Column (SPE) - Inductively Coupled Plasma Mass Spectrometer (ICP-MS). J. of Xiamen Univ. (Natural Science), 2001, 40, 1062-1066
    •  
    • 3. Hu, G; Cai, Y; Yang, C; Wang, X; Huang, Y*. Determination of 27 Elements in two Polymetallic Nodule Reference Samples from the Pacific Ocean by ICP-MS. Haiyang Xuebao, 2002, 24, 47-52
    •  
    • 2. Yang, C; Zhuang, Z; Gu, S; Chen, F; Wu, X*. Application of Isotope Dilution-inductively Coupled Plasma Mass Spectrometry on Trace Element Analysis. J. Instrumental Analysis, 2001, 20, 87-92
    •  
    • 1. Yang, C; Chen, B; Zhuang, Z; Zhao, L; Wang X*. Determination of Trace As, Sb and Bi in the Traditional Chinese Medicine (TCM) with Movable Reducing Bed Hydride Generator (MRBHG) and Inductively Coupled Plasma-Mass spectrometer (ICP-MS), Chem. J. Chin. Univ., 1999, 20, 474
    •  
     
     
    授权专利(获授权专利29)
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    • 1. 杨朝勇,张文华,林水潮,王春明,庄峙厦,周勇亮, 气动微泵及其微流阀控制装置,  专利号200820146194.6,授权日期:2009年6月5日
    • 2. 杨朝勇,胡佳,邬杰,李聪,朱玲,吕忠显,庄峙厦,蛋白酪氨酸磷酸酶SHP2的核酸适体及其制备方法,专利号ZL201010580661.8,授权日期:2012年5月30日
    • 3. 杨朝勇,朱玲,邹远,刘如迪,朱志,庄峙厦,黄曲霉毒素B1的核酸适体AFB1-01及其应用,专利号:ZL201410015297.9,授权日期:2016年05月04日
    • 4. 杨朝勇,朱玲,邹远,刘如迪,朱志,庄峙厦,黄曲霉毒素B1的核酸适体AFB1-04及其应用,专利号:ZL201410015325.7,授权日期:2016年05月04日
    • 5. 杨朝勇,朱玲,邹远,刘如迪,朱志,庄峙厦,黄曲霉毒素B1的核酸适体AFB1-13及其应用,专利号:ZL201410015470.5,授权日期:2016年04月06日
    • 6. 杨朝勇,朱玲,邹远,刘如迪,朱志,庄峙厦,黄曲霉毒素B1的核酸适体AFB1-14及其应用,专利号:ZL201410015127.0,授权日期:2016年04月27日
    • 7. 杨朝勇,朱玲,邹远,刘如迪,朱志,庄峙厦,黄曲霉毒素B1的核酸适体AFB1-20及其应用,专利号:ZL201410015498.9,授权日期:2016年04月27日
    • 8. 杨朝勇,朱玲,邹远,刘如迪,朱志,庄峙厦,黄曲霉毒素B1的核酸适体AFB1-22及其应用,专利号:ZL201410015428.3,授权日期:2016年03月16日
    • 9. 杨朝勇,宋彦龄 安源 邹远 张薇婷 邬杰庄峙厦,上皮细胞粘附因子的核酸适体及其制备方法,专利号 ZL2012 1 0362899.2,授权日期:2014年5月7日
    • 10. 杨朝勇,宋彦龄 安源 邹远 张薇婷 邬杰 庄峙厦,上皮细胞粘附因子的核酸适体Epcam B及其制备方法,专利号:ZL2013 1 0328301.2,授权日期:2016年01月06日
    • 11. 杨朝勇,宋彦龄 安源 邹远 张薇婷 邬杰 庄峙厦,上皮细胞粘附因子的核酸适体Epcam C及其制备方法,专利号:ZL2013 1 0328257.5,授权日期:2016年05月18日
    • 12. 杨朝勇,宋彦龄 安源 邹远 张薇婷 邬杰 庄峙厦,上皮细胞粘附因子的核酸适体Epcam Ccut及其制备方法,专利号:ZL2013 1 0328256.0,授权日期:2016年01月06日
    • 13. 杨朝勇,宋彦龄 安源 邹远 张薇婷 邬杰 庄峙厦,上皮细胞粘附因子的核酸适体Epcam D及其制备方法,专利号:ZL2013 1 0328291.2,授权日期:2016年05月18日
    • 14. 杨朝勇、朱志、宋彦龄、李聪、邹远、朱玲、安源,一种单克隆表面展示核酸适体快速筛选方法,专利号:ZL2014 1 0072695.0 授权日期:2016年02月24日
    • 15. 杨朝勇,李西兰 朱志 欧阳高亮 张伟云 宋彦龄,乳腺癌细胞MDA-MB-231的核酸适体LXL-1及其应用,专利号 ZL2013 1 0314563.3,授权日期:2015年5月13日
    • 16. 杨朝勇,李西兰 朱志 欧阳高亮 张伟云 宋彦龄,乳腺癌细胞MDA-MB-231的核酸适体LXL-2及其应用,专利号 ZL2013 1 0314432.5,授权日期:2015年6月3日
    • 17. 杨朝勇,李西兰 朱志 欧阳高亮 张伟云 宋彦龄,乳腺癌细胞MDA-MB-231的核酸适体LXL-3及其应用,专利号 ZL2013 1 0314448.6,授权日期:2015年4月22日
    • 18. 杨朝勇,张惠敏,宋彦龄,邹远,葛韵,朱志,一种具有光交联基团双吖丙啶的DNA碱基类似物及其合成方法, 专利号ZL201310383256.0,授权日期:2015年9月23日
    • 19. 杨朝勇,张惠敏,马艳丽,朱志, 一种甲基丙烯基亚磷酰胺单体及其合成方法,专利号ZL201410101673.6,授权日期:2015年11月04日
    • 20. 杨朝勇、黄艺顺、张惠敏、马艳丽、朱志,一种高特异性DNA水凝胶对铅离子的检测方法,专利号:ZL201410096353.6,授权日期:2016年08月17日
    • 21. 杨朝勇、魏晓峰、朱志,一种针对多靶标的即时定性分析方法,专利号:ZL20150017670.9,授权日期:2016年09月14日
    • 22. 杨朝勇、李久兴、祝冰青、朱志,一种金纳米棒上快速修饰HS-DNA的方法,专利号:ZL201510193295.3,授权日期:2016年09月07日
    • 23. 杨朝勇,李久兴,祝冰清,马艳丽,严锦懋,阮庆宇,林冰倩,周雷激,朱志,一种强过氧化氢酶活性的纳米颗粒的制备方法,专利号:ZL201510616671.5,授权日期:2017年06月06日
    • 24. 杨朝勇,李久兴,祝冰青,马艳丽,严锦懋,阮庆宇,林冰倩,周雷激,朱志,一种片状银纳米材料的制备方法, 专利号:ZL201510616658.X, 授权日期:2017年6月16日
    • 25. 杨朝勇,官志超,郏莎莎,朱志,一种针对靶标的即时定量方法,专利号:ZL201410057505.1, 授权日期:2017年06月16日
    • 26. 周雷激,刘芳,毛瑜,杨朝勇, 聚甲基丙烯酸缩水甘油微球的合成及表面改性方法,专利号:ZL201510831446.3, 授权日期:2017年07月18日
    • 27. 杨朝勇,刘芳,李久兴,何梦逸,朱志,一种基于具有过氧化物酶活性的纳米酶的ELISA检测方法,专利号:ZL201610347888.5,授权日期:2017年11月10日
    • 28. 杨朝勇,李久兴,刘芳,何梦逸,朱志,一种基于具有过氧化氢酶活性的纳米酶的ELISA检测方法,专利号:ZL201610347565.6,授权日期:2017年11月17日
    • 29. 杨朝勇,李久兴,刘芳,何梦逸,朱志,一种干燥介导金纳米颗粒自主组装金基底的方法及其应用,专利号:ZL201610347942.6, 授权日期:2018年4月6日
    • 30. Tan, Weihong; Yang, Chaoyong. Multi-acceptor molecular probes and applications thereof. PCT Int. Appl.  (2005), 33pp.  CODEN: PIXXD2  WO  2006/002167  A1  20100930  AN 2011:570491, Patent No.: US 8652851B2
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    •  
    申请专利
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    • 1. 杨朝勇,张惠敏,杨圆圆, 一种从孕妇外周血中分离游离胎儿细胞的方法, 申请日:2018年4月3日,申请号:201810289478.9
    • 2. 杨朝勇,王杨,阮庆宇,郑萍萍,张明霞,林水潮,朱志,周雷激,一种基于数字微流控技术和表面增强拉曼散射技术的靶标检测方法及系统,申请日:2017年12月28日,申请号:2017114593326
    • 3. 杨朝勇,阮庆宇,邹芬香,郑萍萍,张明霞,林水潮,周雷激,朱志,一种基于数字微流控技术的掌上焦磷酸测序仪,申请日:2017年11月07日,申请号:201711084328.6
    • 4. 杨朝勇,阮庆宇,王杨,林晓烨,许醒,张东锋,周雷激,朱志,一种基于数字微流控技术的全自动单颗粒/单细胞捕获芯片及其应用,申请日:2017年12月12日,申请号:201711317820.3
    • 5. 杨朝勇,田恬,宋彦龄,吴怡萍,朱志,一种3D集成纸芯片及可视化快速定量检测靶标方法,申请日:2017年08月07日,申请号:201710670159.8
    • 6. 杨朝勇,张东峰,李星锐,一种用于油包水液滴生成的离心式微流控芯片,申请日:2017年09月20日,申请号:201710855088.9
    • 7. 杨朝勇,张东峰,李星锐,一种用于油包水液滴生成的离心式微流控芯片,申请日:2017年09月20日,申请号: 201721209061.4
    • 8. 杨朝勇,张明霞,邹远,朱志,一种高通量配对捕获单细胞/单颗粒的微流控芯片及其应用, 申请日:2017 年 4月26 日,申请号:201710228226.0
    • 9. 杨朝勇,刘丹,周俊恺,朱志,一种基于距离检测靶标的集成化ELISA芯片及其检测方法,申请日:2016 年12 月15 日,申请号:201611159534.4
    • 10. 杨朝勇,梅塔格斯·加绍·艾哈迈德,宋彦龄,朱志,一种循环肿瘤细胞检测芯片及其应用,申请日期2016年03月29日,申请号:201610185666.8
    • 11. 杨朝勇,李久兴,祝冰清,马艳丽,严锦懋,阮庆宇,林冰倩,周雷激,朱志,一种强拉曼信号的纳米颗粒的制备方法,申请日期2015年09月24日,申请号:201510616713.5,公开号:CN105108171A
    • 12. 杨朝勇,官志超,郏莎莎,朱志,刘丹,张明霞,林水潮,李久兴,庄峙厦,基于气压检测的多种靶标的高灵敏定量分析方法,申请日期:2014年6月9日,申请号201410252334.8,申请公布号:CN103994946A
    • 13. 杨朝勇,官志超,郏莎莎,朱志,刘丹,张明霞,林水潮,李久兴,庄峙厦,一种基于气压检测靶标的定量检测方法,申请日期:2014年11月26日,申请号:201410695775.5
    • 14. Mathies, Richard A.; Kumaresan, Palani; Yang, Chaoyang; Blazej, Robert G.   Microfabricated droplet generator, method of amplifying genetic material and high-throughput method of screening cell population.    PCT Int. Appl.  (2009),     49pp.  CODEN: PIXXD2  WO  2009015296  A1  20090129  CAN 150:186202  AN 2009:116112
    • 15. Tan, Weihong; Kim, Youngmi; Yang, Chaoyong James.   Hairpin nucleic acid probes with improved stability and selectivity comprising an L-DNA stem and D-DNA loop structure.    PCT Int. Appl.  (2009),     33pp.  CODEN: PIXXD2  WO  2009035554  A2  20090319  AN 2009:333624
    • 16. Tan, Weihong; Yang, Chaoyong; Vicens, Marie C.; Turro, Nicholas J.; Jockusch, Steffen.   Dual-labeled excimer switching aptamer probe for fluorescent detection of target compounds.    PCT Int. Appl.  (2007),     27pp.  CODEN: PIXXD2  WO  2007075456  A2  20070705  CAN 147:113134  AN 2007:730866
    • 17. Tan, Weihong; Yang, Chaoyong.   Hybrid molecular probe binding to target nucleic acid sequences to produce detectable signals.    PCT Int. Appl.  (2007),     29pp.  CODEN: PIXXD2  WO  2007047434  A1  20070426  CAN 146:456403  AN 2007:463974
    • 18. Tan, Weihong; Wang, Lin; Yang, Chaoyong.   Multiple component nanoparticles for multiplexed signaling and optical encoding.    PCT Int. Appl.  (2007),     33pp.  CODEN: PIXXD2  WO  2007044711  A1  20070419  CAN 146:417837  AN 2007:435777
    • 19. Tan, Weihong; Yang, Chaoyong.   Oligonucleotide probes containing single fluorescent label and multiple quenchers and method for determining molecular interactions.    PCT Int. Appl.  (2006),     64 pp.  CODEN: PIXXD2  WO  2006002167  A2  20060105  CAN 144:101939  AN 2006:11832
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    会议报告及邀请学术报告
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    • 1. 循环肿瘤细胞的识别、富集与单细胞分析,首届微流控技术应用创新论坛  •2017年12月8日 • 深圳,大会报告
    • 2. Aptamer Functionalized Microfluidic Device for Synergistic Enrichment of Circulating Tumor Cells , Asian Federation for Pharmaceutical Sciences Conference Nov 23th, 2017, Xiamen, China, Invited Presentation
    • 3. Aptamer Functionalized Microfluidic Device for Synergistic Enrichment of Circulating Tumor Cells, Nanobiotech-Montreux 2017, November 13th-15th, Montreux, Switzerland, Keynote
    • 4. Enabling Microfluidic Technologies for Circulating Tumor Cell Enrichment and Single-Cell Analysis, The17th Asia-Pacific International Symposium on Microscale Separation and Analysis
    • 5. Nov 10-13th, 2017, Shanghai, China, Invited Presentation
    • 6. Droplet Microfluidics for Circulating Tumor Cell Analysis, MicroTAS 2017, October 22-26, 2017 • Savannah, Georgia, Keynote
    • 7. Nanoparticle Catalyzed Gas-Generation Reaction for Rapid, Sensitive, and Portable Biomedical Analysis, (BCEIA 2017), Beijing, Oct. 9-11, 2017, Keynote Presentation
    • 8. 循环肿瘤细胞的识别、富集与单细胞分析, 第十届全国化学生物学学术年会, 2017.9.24,华中师范大学, 邀请报告
    • 9. Enabling Microfluidic Technologies for Circulating Tumor Cell Enrichment and Single-Cell Analysis, The 11th National Conference on Micro Total Analysis System 22-25th, Sep, 2017 Shenyang, China,Invited Presentation
    • 10. Enabling Microfluidic Technologies for Circulating Tumor Cell Enrichment and Single-Cell Analysis, The sixteenth International Symposium on Electroanalytical Chemistry, Aug17-20, 2017 Changchun, China, Invited Presentation.
    • 11. Droplet Microfluidics for Circulating Tumor Cell Analysis, Optofluidics 2017, July 26-28, Singapore, Keynote.
    • 12. Enabling Microfluidic Technologies for Circulating Tumor Cell Enrichment and Single-Cell Analysis, International Congress on Analytical Sciences, May 5-8, 2017, Haikou, China, 邀请报告
    • 13. Enabling Microfluidic Tools for Enrichment and Single-Cell Analysis of Circulating Tumor Cells, Pittsburgh Conference, March 5-9, 2017, Chicago, IL, USA,邀请报告
    • 14. Nanoparticle Catalyzed Gas-Generation Reaction for Rapid, Sensitive, and Portable Biomedical Analysis, Feb 22-24, 2017, The 3rd SPIE’s International Conference on Nano-Bio Sensing, Imaging & Spectroscopy, Jeju Island, South Korea, 大会报告
    • 15.Enabling Microfluidic Tools for Enrichment and Single-Cell Analysis of Circulating Tumor Cells,December 14th,2016,The Institute of Scientific and Industrial Research,Osaka University, Japan,Invited Presentation
    • 16. Nanoparticle Catalyzed Gas-Generation Reaction for Rapid, Sensitive, and Portable Biomedical Sensing, The 15th Sanken Nanotechnolgy Symposium--Molecular Technology Frontiers towards IoT world, December 12th-13th, 2016, Osaka, Invited Presentation
    • 17. 基于催化产气的生物检测新方法,纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议,2016年12月8-10日,邀请报告
    • 18. Enabling Microfluidic Tools for Enrichment and Single-Cell Analysis of Circulating Tumor Cells,RIKEN, December 7th,2016, Tokyo, Japan,Invited Presentation
    • 19. Target Responsive Aptamer Crosslinked Hydrogel for Point-of-Care Testing Applications,The 2016 International Workshop on Supramolecular Chemistry and Functional Materials,December 3-6th,2016,  Manza Hotel, Tsumagoi, Gunma, Japan, 邀请报告
    • 20. 基于催化产气的生物检测新方法, 第三届食品药品、环境分析测试学术研讨会, 2016.11.26, 厦门, 邀请报告
    • 21. 循环肿瘤细胞高效捕获与单细胞分析, 2016精准医学、精准药学中的微流控芯片高端论坛, 江苏师范大学, 2016年11月18-21日, 邀请报告
    • 22. Droplet Microfluidics for Highly Efficient Evolution of Recognition Ligands at the Single-molecule  Level , Lab on a Chip International Symposium: Droplet-based Microfluidics, Hangzhou Nov 11-13 2016, Invited Presentation
    • 23. Enabling Microfluidic Tools for Enrichment and Single-Cell Analysis of Circulating Tumor Cells, International Symposium on Basic Sciences, Incheon National University, Korea  2016-Nov-3, Invited Presentation
    • 24. Enabling Microfluidic Tools for Enrichment and Single-Cell Analysis of Circulating Tumor Cells, 第一届循环肿瘤细胞检测与分析学术论坛,江汉大学, 2016-Oct-30, 邀请报告
    • 25. Enabling Microfluidic Tools for Enrichment and Single-Cell Analysis of Circulating Tumor Cells , 2016 International Experimental Biology and Medicine Conference&International Regenerative Medicine and Health Industry Forum-Single Cell Analyses in Disease, 2016-Oct-28-29, Chengdu, Invited Presentation.
    • 26. Nanoparticle Catalyzed Gas-Generation Reaction for Rapid, Sensitive, and Portable Biomedical Sensing, NanoBio China 2016, Oct 17-18th, 2016, Nanjing, Invited Presentation
    • 27. Enabling Microfluidic Tools for Enrichment and Single-Cell Analysis of Circulating Tumor Cells , International Conference on Chemical Biology Frontier Program, September 24-26, 2016 Wuhan, Invited Presentation
    • 28. 单细胞分析, 30届中国化学会年会化学生物学分会,大连,2016年7月1-3日,邀请报告
    • 29. 基于催化产气的生物检测新方法,30届中国化学会年会纳米传感新原理新方法分会,大连,2016年7月1-3日,邀请报告
    • 30. 基于液滴微流控的多肽筛选新方法及其应用,30届中国化学会年会生物分析和生物传感分会,大连,2016年7月1-3日,邀请报告
    • 31. Evolving Nucleic Acid and Peptide Aptamers for Bioanalysis and Biomedicine, 中美华人化学教授会议, 2016 June 23-26,邀请报告
    • 32. 结构DNA纳米技术用于酶通道的定向调控, 全国生物物理化学会议, 2016 June14-17, Hefei, 邀请报告
    • 33. Translating Molecular Recognition into Pressure Signal for Rapid, Sensitive, and Portable Biomedical Analysis , The 6th International Symposium on Biomedical Engineering Bioanalysis and Nanotechnology,湖南长沙,2016年5月28日,邀请报告
    • 34. Microfluidic Devices with Target Responsive Aptamer-crosslinked Hydrogel for Visual Quantitative Point-of-Care Testing,The 2016 China-Canada Analytical Chemistry Conference,May 12-15, Chongqing, 邀请报告
    • 35. 基于距离的微流控即时检测新方法,全国微全分析学术会议,2016年5月6-9日,兰州
    • 36. 微流控技术在循环肿瘤细胞富集与单细胞分析中的研究进展,中国科学仪器发展年会, 2016年4月22日,南京, 邀请报告
    • 37. 微流控芯片结合靶标响应水凝胶在可视化定量即时检测中的应用,  2016年3月16日,南京大学,邀请报告
    • 38. Microfluidic Devices with Target Responsive Aptamer-crosslinked Hydrogel for Visual Quantitative Point-of-Care Testing, 深圳-大连微流控芯片及其产业化战略研讨会,Dec 12-13, 2015, 深圳, 邀请报告
    • 39. Tagging Diseased Cells with Synthetic Ligands,Xiamen-Dundee University Joint Workshop on Chemical Biology,Nov 15, 2015,Xiamen, 邀请报告
    • 40. Translating Molecular Recognition into Pressure Signal for Rapid, Sensitive, and Portable Biomedical Analysis, International Symposium on Analytical Sensors, 2015 Nov 5, Fuzhou, Invited Presentation.
    • 41. Enabling Microfluidic Technologies for High Throughput Single Cell Analysis, 16th International Beijing Conference and Exhibition on Instrumental Analysis (BCEIA 2015), Beijing, Oct. 27-30, 2015, Keynote Presentation
    • 42. Enabling Microfluidic Technologies for High Throughput Single Cell Analysis, Beijing Symposium on Frontiers at the Chemistry and Biology Interface· Oct 24-25, 2015, Invited Presentation
    • 43. 核酸适体筛选新方法, 第九次鼓岭科学会议,福州, 2015年10月17日,邀请报告
    • 44. A Microfluidic Device Integrating Size based Separation and Affinity Capturing for Synergistic Enrichment of Circulating Tumor, HPLC 2015, Beijing, Sep 21-25, Invited Presentation
    • 45. Evolution of DNA Aptamers through in vitro Metastatic-cell-based SELEX for Metastatic Cancer Recognition and Imaging, Asia 3 Roundtable on Nucleic Acids 2015, Sep 18-20, Suwon, Korea, Invited Presentation.
    • 46. A Microfluidic Device Integrating Size based Separation and Affinity Capturing for Synergistic Enrichment of Circulating Tumor Cells, 第九届全国化学生物学学术会议2015 Aug 28-31, Tianjin, Invited Presentation
    • 47. A Microfluidic Device Integrating Size based Separation and Affinity Capturing for Synergistic Enrichment of Circulating Tumor Cells, The 5th International Conference on Optofluicids, 2015 July 27, Taipei, Taiwan, Keynote Presentation
    • 48. Droplet Microfluidics for High Throughput Single-Cell Analysis, 2015 July 17, 2015 Beijing Genomics Frontiers Symposium, Invited Presentation
    • 49. Enriching Circulating Tumor Cells with Aptamers, The Fourth International Conference on DNA Nanotechnology, 2015 July 27-29, Xian, Keynote Presentation
    • 50. Efficient Enrichment of Circulating Tumor Cells with Aptamer Functionalized Microfluidic Devices, Sino-German-Symposium Frontiers of Chromatography and Mass Spectrometry in -omics Time, 2015 June 17-21. Essen, German, 邀请报告
    • 51. Droplet Microfluidics for High Throughput Single-Cell Analysis with Single-Molecule Sensitivity,2015年6月5日,北京大学,邀请报告
    • 52. Droplet Microfluidics for High Throughput Single-Cell Analysis with Single-Molecule Sensitivity,2015年5月27日,江苏师范大学,邀请报告
    • 53. Droplet Microfluidics for High Throughput Single-Cell Analysis with Single-Molecule Sensitivity,2015年6月11日,武汉大学,邀请报告
    • 54. Droplet Microfluidics for High Throughput Single-Cell Analysis with Single-Molecule Sensitivity,2015年5月9日,华中科技大学,邀请报告
    • 55. Evolution of Functional Nucleic Acid Probes for Bioanlysis and Biomedicine,2015年1月9日,香港大学,邀请报告
    • 56. Target Responsive Aptamer Crosslinked Hydrogel for Visual Quantitative Point-of-Care Testing, Summit of Biomedical and Health Engineering 2015,Jan 05, 2015, Shenzhen Institutes of Advanced Technology, CAS, 邀请报告
    • 57. Hydrogel Microfluidics for Single-Molecule Detection, Single-Cell Analysis and Point-of-Care Testing Applications,中国科学院电子学研究所传感技术联合国家重点实验室,2014年12月2日,邀请报告
    • 58. Evolution of Functional Nucleic Acid Probes for Biomedicine, Kaohsiung, Taiwan, IEEE NanoMED 2014,  Nov. 9-12, 2014, Keynote Presentation
    • 59. Hydrogel Microfluidics for Single-Molecule Detection, Single-Cell Analysis and Point-of-Care Testing Applications, National μTAS / National MSB/ICM&MSB 2014, Oct 30-Nov 2, 2014 · Wuhan · China, Keynote Presentation.
    • 60. Target-Responsive DNA Hydrogel for Point-of-Care Applications, Asian 3 Roundtable on Nucleic Acids, Oct 17-19, Xiamen, Invited Presentation
    • 61. Functional Nucleic Acid Probes for Bioanalysis and Biomedicine, 5th Sino-German Frontiers of Chemistry Symposium Meeting Challenges in Chemistry and Chemical Biology, September 7-14, 2014 · BERLIN · Germany, Invited Presentation,
    • 62. 即时可视化定量检测微流控方法, 29届中国化学会年会分析化学分会,北京,2014年8月,邀请报告
    • 63. Target Responsive DNA Hydrogel for Visual Quantitative Point-of-Care Testing, Lab on a Chip Industry Workshop-Microfluidic Applications, 2-3 August 2014, Dalian, China, Invited Presentation
    • 64. Microfluidic Devices with Target Responsive Hydrogel for Visual Quantitative Point-of-Care Testing , The 6th International Symposium on Microchemistry and Microsystems July 30th-August 1st, 2014, Singapore, Keynote Presentation, Invited Presentation
    • 65. Droplet Microfluidics for High Throughput Single-Cell Analysis with Single-Molecule Sensitivity, 南京大学现代工学院天地论坛,南京,2014年6月5日,邀请报告
    • 66. A High Throughput Single-Molecule Counting Method for Digital Enzyme Detection , The 6th International Symposium on Biomedical Engineering Bioanalysis and Nanotechnology,湖南长沙,2014年5月29日,邀请报告
    • 67. Target Responsive DNA Hydrogel for Visual Quantitative Point-of-Care Testing, The 3rd International Workshop on DNA Nanotechnology,苏州,2014年5月25日.
    • 68. Droplet Microfluidics for High Throughput Single-Cell Analysis with Single-Molecule Sensitivity, 南京大学校庆讲座,南京,2014年5月16日,邀请报告
    • 69. Xiamen Forum on Soft Matter and Interface, Xiamen, Nov 29-Dec 1, 2013, Invited Presentation
    • 70. DASAN Conference for "Bio and Eco-sensing Technology for U-health and Environment", Jeju, Korea, Nov. 20-23, 2013, Keynote Presentation.
    • 71. 中国科学院深圳先进技术研究院,深圳,2013年11月8日,邀请报告
    • 72. A High Throughput Single-Molecule Counting Method for Digital Enzyme Detection , The 9th International Forum on Post-Genome Technologies, Shenzhen, Nov 6-8, Invited Presentation.
    • 73. International Conference on Biosensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS and Applications 2013, Tokyo, Oct. 30-31, 2013, Invited Presentation.
    • 74. 15th BCEIA,  Beijing,  Oct 23-26, 2013, Keynote Presentation
    • 75. 复杂样品分析研讨会,江西南昌东华理工大学,2013年10月13日-15日,邀请报告
    • 76. 第八届全国化学生物学学术会议,上海,2013年9月15日至18日,邀请报告
    • 77. A3RONA 2013, Kobe,Japan, Aug 30-Sep 1,Invited Talk
    • 78. 湖南大学化学计量学与化学生物传感国家重点实验室,2013年6月24日,邀请报告
    • 79. 第19届全国色谱学术报告会及仪器展览会, 福州,2013年3月31-4月24日,邀请报告
    • 80. Pittsburgh Conference, March17-21, 2013, Philadelphia, Pennsylvania, USA,邀请报告
    • 81. 第三届中国工程前沿青年研讨会,北京,2012年11月30日,邀请报告
    • 82. 第十一届全国分析化学年会,青岛,2012年10月26日~29日,邀请报告
    • 83. 第七届中美华人纳米论坛,中国厦门,2012年6-9日,邀请报告
    • 84. Massively Parallel Single-Molecule PCR in Microfluidic Droplets for Robust and Efficient DNA Cloning,第八届中美华人化学教授会议,云南昆明,2012年7月1-4日,邀请报告
    • 85. The Fourth International Symposium on Biomedical Engineering Bioanalysis andNanotechnology,湖南长沙,2012年6月7-10,邀请报告
    • 86. 第七届全国微全分析学术会议,2012年4月,杭州,邀请报告
    • 87. 8届中国化学会年会分析化学分会,成都,2012年4月,邀请报告
    • 88. The 6th Workshop “Chemical and Biological Micro Laboratory Technology,Elgersburg, Germany,2012-3-20,邀请报告(Keynote)
    • 89. Workshop on DNA Nanotechnology: From Structure To Function,March 17,上海
    • 90. 全国核酸适体学术会议,2011年11月11日-13日,安徽合肥,邀请报告
    • 91. 第十一届全国化学传感器学术会议,2011年10月22日-25日,湖南长沙,邀请报告
    • 92. The 14th Asian Chemical Congress,Symposium on Recent Progresses in Lab on a Chip and its Application,2011年9月5日-8日,泰国,曼谷,邀请报告
    • 93. 第七届全国化学生物学学术会议,南京,2011年8月26-29日,邀请报告
    • 94. The 11th Asian Conference on Analytical Sciences (ASIANALYSIS XI), 2011年9月23日-26日,南京,邀请报告
    • 95. 中国微米纳米技术学会纳米科学技术分会第二届年会暨2010全国纳米生物医学学术会议,2010年11月4-7日,武汉,邀请报告
    • 96. 2010年微纳尺度分离和分析技术学术会议及第六届全国微全分析学术会议,2010年10月17-20,上海,邀请报告
    • 97. 第14届国际微全分析会议,荷兰格罗宁根,2010年10月3-7日,口头报告
    • 98. 27届中国化学会年会分析化学分会,厦门,2010年6月,邀请报告
    • 99. 27届中国化学会年会化学生物学分会,厦门,2010年6月,邀请报告
    • 100. 27届中国化学会年会化学生物学分会,厦门,2010年6月,邀请报告
    • 101. The Fourth International Symposium on Biomedical Engineering Bioanalysis and Nanotechnology,湖南长沙,2010年6月,邀请报告
    • 102. Pittsburgh Conference, March, 2010, Orlando,Florida,邀请报告,
    • 103. 厦门,2009年10月22-26日,邀请报告
    • 104. 香山科学会议第365次学术讨论会,北京,2009年12月16-18日,邀请报告
    • 105. 2009肿瘤生物标志物的临床应用研讨会,国内会议,2009年11月6-9日
    • 106. 仿生材料与器件研讨会暨重大研究计划联合交流会, 国内会议,2009年8月23-25日,北京航天航空大学
    • 107. The 2nd Sino-German Frontiers of Chemistry Symposium ,厦门,2008年10月9-11日,邀请报告,
    • 108. 第二届纳米生物化学国际系列研讨会, 法国巴黎,2008年9月29日,邀请报告
    • 109. 中国化学会第二十六届学术年会,邀请报告, 天津,2008年7月13-16日
    • 110. The Third International Symposium on Biomedical Engineering Bioanalysis and Nanotechnology, 湖南长沙,2008年6月8-11日,邀请报告

  • Zhi Zhu

    86-18750268060; zhuzhi8420@gmail.com; zhuzhi@xmu.edu.cn

    Working Experience______________________________________________________________
    • Aug 2015-present       Professor, Department of Chemical Biology, College of Chemistry and Chemical Engineering,  Xiamen University, Xiamen, China
    • Jan 2012-present       Associate Professor, Department of Chemical Biology,College of Chemistry and
    Chemical Engineering, Xiamen University, Xiamen, China
    • Aug 2011-Jan 2012    Assistant Professor,  Department of Chemical Biology, College of Chemistry and
    Chemical Engineering, Xiamen University, Xiamen, China
    EDUCATION____________________________________________________________________                                                        
    • University of Florida, Ph.D. in Analytical Chemistry,May 2011    Gainesville, FL   
    Research Advisor: Dr. Weihong Tan
    • Peking University,  B. S. Chemistry, 2006Beijing, China                           
    Research Advisor: Dr. Chunhua Yan
    RESEARCH EXPERIENCE________________________________________________________
    2012-Present Associate Professor, Xiamen University                                                                          Xiamen, China
    2011-2012Assistant Professor, Xiamen University         Xiamen, China
    • DNA self-assembly and molecular engineering for cancer diagnosis
    • Microfluidics for single molecule and single cell analysis
    2007 – 2011Research Assistant, University of FloridaGainesville, FL 
    (Supervisor: Dr. Weihong Tan)
    • Functional-DNA cross-linked, target-responsive hydrogel for sensitive visual detection
    • Molecular mediation of photodynamic therapyusing carbonnanomaterials
    2006 – 2007 Teaching Assistant, University of Florida   Gainesville, FL
    (Supervisor: Dr. James C. Horvath)
    • Teaching assistant for general chemistry lab II
    2004 – 2006Undergraduate Research Assistant, Peking University            Beijing, China
    (Supervisor: Dr. Chunhua Yan)
    • Synthesis and properties of tetrathiafulvalene derivative pending a fluorophore
    HONORS AND AWARDS__________________________________________________________
    • 2010    Chinese Government Award for Outstanding Students Aboard
    • 2009    ACS Division of Analytical Chemistry Nine-Month Graduate Fellowship
    • 2009   Roger G. Bates and Herbert A. Laitinen Fellowships, University of Florida
    • 2008   Crow and Stasch Awards for excellence in scientific publication, University of Florida
    • 2008 Honorary Mention for Poster Presentation at the 1st Annual Nanoscience Technology Symposium held at
    University of Central Florida
    • 2007   Graduate Achievement Award, University of Florida
    • 2006-present    Alumni Fellowship, University of Florida
    • 2005    Xianglu Fellowship (for outstanding achievement, versatile personality and excellent studentwork),
    Peking University
    • 2004    Model of Outstanding Students, Peking University
    • 2003    Second-class national Scholarship, Peking University
    Xiyue Fellowship, Peking University
    • 2002    First-class National Scholarship (for freshmen with excellent records in the entrance examination to
    colleges and universities), Peking University
    PUBLICATIONS_________________________________________________________________
    • Ling Yan, Zhi Zhu, Yuan Zou, Yishun Huang, Dewen Liu, ShashaJia, DunmingXu, Min Wu, Yu Zhou, Shuang Zhou, Chaoyong James Yang. “Target-responsive ‘Sweet’ Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-glucose Targets.” Journal of the American Chemical Society,2013,DOI: 10.1021/ja3114714. (Co-first authors)
    • Da Han,Zhi Zhu, Cuichen Wu, Lu Peng, Leiji Zhou, BasriGulbakan, Guizhi Zhu, Kathryn R. Williams, and Weihong Tan. “A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer–Protein Interactions.”Journal of the American Chemical Society,2012,134,20797-20804.(Co-first authors)
    • Ling Zhu, Cong Li, Zhi Zhu, Dewen Liu, Yuan Zou, ChunmingWang, Hao Fu, Chaoyong James Yang. “In Vitro Selection of Highly Efficient G-Quadruplex-Based DNAzymes.”Analytical Chemistry, 2012,84, 8383-8390. (co-first authors)
    • Jie Wu, Chi Wang, Xilan Li, Yanling Song, Wei Wang, Cong Li, Jia Hu, Zhi Zhu*, Jiuxing Li, Weiyun Zhang, Zhongxian Lu*, Chaoyong James Yang*. “Identification, Characterization and Application of a G-Quadruplex Structured DNA Aptamer against Cancer Biomarker Protein Anterior Gradient Homolog 2.”Plos One, 2012, 7, e46393.
    • Cong Li, Ling Zhu, Zhi Zhu, Hao Fu, Gareth Jenkins, Chunming Wang, Yuan Zou, Xin Lu, Chaoyong James Yang. “Backbone Modification Promotes Peroxidase Activity of G-Quadruplex-Based DNAzyme.”Chem. Commun.,2012, 48,8347-8349. (co-first authors)
    • Zhi Zhu, Wenhua Zhang, XuefeiLeng, Mingxia Zhang, Zhichao Guan and Chaoyong James Yang. “Highly Sensitive and Quantitative Detection of Rare Pathogens through Agarose Droplet Microfluidic Emulsion PCR at the Single-Cell Level.”Lab Chip, 2012, 12, 3907-3913.
    • ZhiZhu, Gareth Jenkins, WenhuaZhang,Mingxia Zhang,ZhichaoGuan, Chaoyong James Yang. “Single-Molecule Emulsion PCR in Microfluidic Droplet.” Analytical Bioanalytical Chemistry, 2012,403, 2127-2143.
    • Yanling Song, Weiting Zhang, Yuan An, Liang Cui, Chundong Yu,Zhi Zhu*, Chaoyong James Yang*. “Label-free visual detection of nucleic acids in biological samples with single-base mismatch detection capability.”Chem. Commun.,2012, 48, 576–578.
    • Ying Pu, Zhi Zhu, Da Han, Huixia Liu, Jun Liu, Jie Liao, Kejing Zhang, Weihong Tan. “Insulin-Binding Aptamer-Conjugated Graphene Oxide for Insulin Detection.”Analyst, 2011,47, 4138-4140. (co-first authors)
    • Chungming Wang, Zhi Zhu, Yanling Song, Hui Lin, Chaoyong James Yang, Weihong Tan. “Caged Molecular Beacons: Controlling Nucleic Acid Hybridization with Light.”Chem. Commun.,2011, 47, 5708-5710. (co-first authors)
    • Zhi Zhu, Cuichen Wu, Haipeng Liu, Yuan Zou, Xiaoling Zhang, Huaizhi Kang, Chaoyong James Yang, Weihong Tan. “An Aptamer Cross-linked Hydrogel as a Colorimetric Platform for Visual Detection.” Angew. Chem. Int. Ed., 2010, 49, 1052-1056.
    • Zhi Zhu, Ronghua Yang, Mingxu You, Xiaoling Zhang, Yanrong Wu, Weihong Tan. “Single-walled Carbon Nanotube as an Effective Quencher.” Analytical Bioanalytical Chemistry, 2010,396, 73-83.
    • Zhi Zhu, Zhiwen Tang, Joseph A. Phillips, Ronghua Yang, Hui Wang, Weihong Tan. “Regulation of Singlet Oxygen Generation Using Single-Walled Carbon Nanotubes.”Journal of the American Chemical Society,2008, 130, 10856-10857.
    • Tao Chen, CuichenSam Wu, Elizabeth Jimenez, Zhi Zhu, Joshua G. Dajac, Mingxu You, Da Han, Xiaobing Zhang and Weihong Tan. “DNA Micelle Flares for Intracellular mRNA Imaging and Gene Therapy.”Angew. Chem. Int. Ed.,2013, DOI: 10.1002/anie.201209440.
    • GuoliangKe, Chunming Wang, Yun Ge, NanfengZheng, Zhi Zhu,Chaoyong James Yang. “L-DNA Molecular Beacon: A Safe, Stable, and Accurate Intracellular Nano-thermometer for Temperature Sensing in Living Cells.”Journal of the American Chemical Society,2012,134, 18908-18911.
    • Xiaohong Tan, Tao Chen, Xiangling Xiong, Ye Mao, Guizhi Zhu, Emir Yasun, Chunmei Li, Zhi Zhu, Weihong Tan. “Semiquantification of ATP in Live Cells Using Nonspecific Desorption of DNA from Graphene Oxide as the Internal Reference.”Analytical Chemistry, 2012,84, 8622-8627.
    • Xiaohong Tan, Weijun Chen, Shun Lu, Zhi Zhu, Tao Chen, Guizhi Zhu, Mingxu You, Weihong Tan. “Molecular Beacon Aptamers for Direct and Universal Quantitation of Recombinant Proteins from Cell Lysates.”Analytical Chemistry, 2012,84, 8272-8276.
    • Dezhi Kang, Jiangjie Wang, Weiyun Zhang, Yanling Song, Xilan Li, Yuan Zou, Mingtao Zhu,Zhi Zhu, Fuyong Chen, Chaoyong James Yang. “Selection of DNA Aptamers against Glioblastoma Cells with High Affinity and Specificity.”Plos One, 2012, 7, e42731.
    • Xue-Qin Zhao, Jie Wu, Jing-Hong Liang, Jia-Wei Yan, Zhi Zhu, Chaoyong James Yang, Bing-Wei Mao. “Single-Molecule Force Spectroscopic Studies on Intra- and Intermolecular Interactions of G-Quadruplex Aptamer with Target Shp2 Protein.”Journal of Physical ChemistryB, 2012, 116, 11397-11404.
    • Liang Cui, Yuan Zou, Ninghang Lin, Zhi Zhu, Gareth Jenkins, Chaoyong James Yang. “Mass Amplifying Probe for Sensitive Fluorescence Anisotropy Detection of Small Molecules in Complex Biological Samples.”Analytical Chemistry, 2012,84, 5535-5541.
    • HuifaZhang, Gareth Jenkins, Yuan Zou,ZhiZhu, Chaoyong James Yang. “Massively Parallel Single-Molecule and Single-Cell Emulsion Reverse Transcription Polymerase Chain Reaction Using Agarose Droplet Microfluidics.”Analytical Chemistry, 2012,84, 3599-3606.
    • Lu Peng, Zhi Zhu, Yan Chen, Da Han, Weihong Tan. “An Exonuclease III and GrapheneOxide-Aided Assay for DNA Detection.”Biosensors Bioelectronics, 2012,35, 475-478.
    • Mohammed I.Shukoor,  Meghan O.Altman, Da Han,Abdullah TahirBayrac, Ismail Ocsoy,ZhiZhu, WeihongTan. “Aptamer-Nanoparticle Assembly for Logic-Based Detection.”ACS Applied Materials & Interfaces, 2012,4, 3007-3011.
    • Jian Wang, Guizhi Zhu, Mingxu You, Erqun Song, Mohammed I.Shukoor, Kejing Zhang, Meghan O.Altman, Yan Chen, Zhi Zhu, Cheng Zhi Huang, Weihong Tan. “Assembly of Aptamer Switch Probes and Photosensitizer on Gold Nanorods for Targeted Photothermal and Photodynamic Cancer Therapy.”ACS Nano, 2012, 6, 5070-5077.
    • Bin-Cheng Yin, Bang-Ce Ye, Hui Wang, Zhi Zhu, Weihong Tan. “Colorimetric logic gates based on aptamer-crosslinked hydrogels.”Chem. Commun.,2012, 48, 1248–1250.
    • Weiyun Zhang, Wenhua Zhang, Zhiyuan Liu, Cong Li, Zhi Zhu, Chaoyong Yang. “Highly Parallel Single-Molecule Amplification Approach Based on Agarose Droplet Polymerase Chain Reaction for Efficient and Cost-Effective Aptamer Selection.”Analytical Chemistry,2012, 84, 350-355.
    • Liang Cui, Xiaoyan Lin, Ninghang Lin, Yanling Song,Zhi Zhu, Xi Chen, Chaoyong James Yang. “Graphene oxide-protected DNA probes for multiplex microRNA analysis in complex biological samples based on a cyclic enzymatic amplification method.”Chem.Commun.,2012, 48, 194-196.
    • Jun Liu, Huixia Liu, Huaizhi Kang, Michael Donovan, Zhi Zhu, Weihong Tan. “Aptamer-incorporated hydrogels for visual detection, controlled drug release, and targeted cancer therapy.”Analytical Bioanalytical Chemistry, 2012,402, 187-194.
    • Kelong Wang, Mingxu You, Yan Chen, Da Han, Zhi Zhu, Jin Huang, Kathryn William, Chaoyong James Yang, Weihong Tan. “Self-assembly of aBifunctionalDNA Carrier for Drug Delivery.”Angew. Chem. Int. Ed.,2011, 50,6098-6101.
    • Da Han, Jin Huang, Zhi Zhu, Quan Yuan, Mingxu You, Yan Chen and Weihong Tan. “Molecular Engineering of Photoresponsive Three-dimensional DNA Nanostructures.” Chem. Commun.,2011,47, 4670-4672.
    • Jin Huang, Yan Chen, Liu Yang,Zhi Zhu, Guizhi Zhu, Xiaohai Yang, Kemin Wang, Weihong Tan. “Amplified detection of cocaine based on strand-displacement polymerizationand fluorescence resonance energy transfer.”Biosensors Bioelectronics, 2011,28, 450-453.
    • Zhuo Chen, Xiaobing Zhang, Ronghua Yang, Zhi Zhu, Yan Chen and Weihong Tan. “Single-walled Carbon Nanotubes as Optical Materials for Biosensing.” Nanoscale,2011,3, 1949-1956.
    • Jin Huang, Yanrong Wu, Yan Chen, Zhi Zhu, Xiaohai Yang, Chaoyong James Yang, Kemin Wang and Weihong Tan. “Pyrene-Excimer Probes Based on the Hybridization Chain Reaction for the Detection of Nucleic Acids in Complex Biological Fluids.” Angew. Chem. Int. Ed.,2011, 50, 401-404.
    • Huaizhi Kang, Haipeng Liu, Xiaoling Zhang, Jilin Yan, Zhi Zhu, Lu Peng, Huanghao Yang, Youngmi Kim, Weihong Tan. “Photoresponsive DNA-Cross-Linked Hydrogels for Controllable Release and Cancer Therapy.”Langmuir, 2011,27, 399-408.
    • Yamin Li, Xiaoling Zhang, Baocun Zhu, Juan Xue, Zhi Zhu, Weihong Tan. “A Simple but Highly Sensitive and Selective Colorimetric and Fluorescent Probe for Cu2+ in Aqueous Media.” Analyst, 2011,136, 1124-1128.
    • Tao Chen, Mohammed Ibrahim Shukoor, Yan Chen, Quan Yuan, Zhi Zhu,Zilong Zhao, BasriGulbakan, Weihong Tan. “Aptamer-conjugated Nanomaterials for Bioanalysis and Biotechnology Applications.” Nanoscale, 2011, 3, 546-556.
    • Ying Pu, Zhi Zhu, Huixia Liu, Jiani Zhang, Jun Liu, Weihong Tan. “Using Aptamers to Visualize and Capture Cancer Cells.” Analytical Bioanalytical Chemistry,2010, 397, 3225-3233.
    • Jin Huang, Zhi Zhu, SuwussaBamrungsap, Guizhi Zhu, Mingxu You, Xiaoxiao He, Kemin Wang, Weihong Tan. “Competition-Mediated Pyrene-Switching Aptasensor: Probing Lysozyme in Human Serum with a Monomer-Excimer Fluorescence Switch.”Analytical Chemistry, 2010,82, 10158-10163.
    • Basri Gulbakan, Emir Yasun, M. Ibrahim Shukoor, Zhi Zhu, Mingxu You, Xiaohong Tan, Hernan Sanchez, David H. Powell, Hongjie Dai, Weihong Tan.“A Dual Platform for Selective Analyte Enrichment and Ionization in Mass Spectrometry Using Aptamer-Conjugated Graphene Oxide.”Journal of the American Chemical Society, 2010,132, 17408-17410.
    • Mingxu You, Zhi Zhu,Haipeng Liu, BasriGulbakan, Da Han, Ruoren Wang, Kathryn R. Williams, Weihong Tan. “Pyrene-Assisted Efficient Photolysis of Disulfide Bonds in DNA-Based Molecular Engineering.”ACS Applied Materials & Interfaces, 2010,2, 3601-3605.
    • Haipeng Liu, Zhi Zhu, Huaizhi Kang, Yanrong Wu, Kwame Sefan, Weihong Tan.“DNA-Based Micelles: Synthesis, Micellar Properties and Size-Dependent Cell Permeability.”Chemistry--A European Journal,2010, 16, 3791-3797,
    • Zhiwen Tang, Zhi Zhu, PrabodhikaMallikaratchy, Ronghua Yang, Kwame Sefah, Weihong Tan. “Aptamer-Target Binding Triggered Molecular Mediation of Singlet Oxygen Generation.”Chemistry--An Asian Journal,2010, 5, 783-786.
    • Yan Liu; Se Won Bae, Kelong Wang, Jong-In Hong, Zhi Zhu, Weihong Tan, Dimitri Pappas. “The Effects of Flow Type on Aptamer Capture in Differential Mobility Cytometry Cell Separations.” AnalyticaChimicaActa,2010, 673, 95-100.
    • Xiaolan Chen, M.-Carmen Estevez, Zhi Zhu, Yu-fen Huang, Yan Chen, Lin Wang, Weihong Tan. “Using Aptamer-Conjugated Fluorescence Resonance Energy Transfer Nanoparticles for Multiplexed Cancer Cell Monitoring.”Analytical Chemistry, 2009, 81,7009-7014.
    • Hui Wang, Youngmi Kim, Haipeng Liu, Zhi Zhu, Suwussa Bamrungsap, Weihong Tan.  “Engineering a Unimolecular DNA-Catalytic Probe for Single Lead Ion Monitoring.”Journal of the American Chemical Society,2009,131, 8221-8226.
    • Yan Chen, Alina C. Munteanu, Yu-Fen Huang, Joseph Phillips,Zhi Zhu, Michael Mavros, Weihong Tan. “Mapping Receptor Density on Live Cells Using Fluorescence Correlation Spectroscopy.”Chemistry-A European Journal, 2009, 15, 5327-5336.
    • Zhiwen Tang,PrabodhikaMallikaratchy, Ronghua Yang,Youngmi Kim, Zhi Zhu,Hui Wang,Weihong Tan. “Aptamer Switch Probe Based on Intramolecular Displacement.”Journal of the American Chemical Society,2008,130, 11268-11269.
    • Ronghua Yang, Jianyu Jin, Yan Chen, Na Shao, Huaizhi Kang, Zeyu Xiao, Zhiwen Tang, Yanrong Wu, Zhi Zhu, Weihong Tan.“Carbon Nanotube-Quenched Fluorescent Oligonucleotides: Probes that Fluoresce upon Hybridization.”Journal of the American Chemical Society, 2008,130, 8351-8358.
    • Joseph A. Phillips, Dalia Colon-Lopez, Zhi Zhu, Ye Xu, Weihong Tan. “Applications of Aptamers in Cancer Cell Biology.” AnalyticaChimicaActa, 2008,621, 101-108.
    • Ronghua Yang,Zhiwen Tang,Jilin Yan, Huaizhi Kang,Youngmi Kim,Zhi Zhu,Weihong Tan.   “Noncovalent Assembly of Carbon Nanotubes and Single-Stranded DNA: An Effective Sensing Platform for Probing Biomolecular Interactions.” Analytical Chemistry,2008, 80, 7408-7413.
    • Wei Sun, Chun-Hu Xu, Zhi Zhu, Chen-Jie Fang, and Chun-Hua Yan.“Chemical-Driven Reconfigurable Arithmetic Functionalities within a Fluorescent Tetrathiafulvalene Derivative.” Journal of Physical Chemistry C, 2008,112, 16973-16983.
    • Chen-Jie Fang, Zhi Zhu, Wei Sun, Chun-Hu Xu, Chun-Hua Yan. “New TTF derivatives: Several molecular logic gates based on their switchable fluorescent emissions.”New Journal of Chemistry, 2007, 31, 580-586.
    PRESENTATIONS_______________________________________________________________
    • Zhi Zhu. “Portable and Quantitative Detection Platform Based on Functional DNA Crosslinked Hydrogel.”5thInternational Symposium on Biomedical Engineering, Bioanalysis and Nanotechnology, Changsha, China, June, 2012
    • Zhi Zhu. “Carbon Nanomaterials as Effective Quenchers for Biosensing and Targeted Therapy.”3rd Asian Spectroscopy Conference, Xiamen, China, November 2011
    • Zhi Zhu, Jin Huang, Xiangling Xiong, Weihong Tan. “mRNA/Graphene oxide for molecular mediation of photodynamic therapy. ” 241st ACS National Meeting & Exposition, Anaheim, CA, March 2011
    • Zhi Zhu, Mohammed Ibrahim Shukoor, Weihong Tan. “Logic Switchboard for Medical Diagnosis.”62ndPittsburgh Conference, Atlanta, GA, March 2011
    • Zhi Zhu, Haipeng Liu, Chaoyong James Yang, Weihong Tan.“Functional DNA cross-linked hydrogel for visual detection.”Gordon Research Conference 2010, Bioanalytical Sensors, New London, NH, June 2010
    • Zhi Zhu, Weihong Tan. “Aptamer-switches for Bioanalytical and Biomedical Applications.” Invited Seminar, Proctor & Gamble, Cincinnati, OH, March2010
    • Zhi Zhu, Haipeng Liu, Chaoyong Yang, Weihong Tan. “Aptamer cross-linked Hydrogel for Visual Detection.” 61stPittsburgh Conference, Orlando, FL, March2010
    • Zhi Zhu, Weihong Tan. “Target-responsive Aptamer-switches for Bioanalytical and Biomedical Applications.” Invited Seminar, Xiamen University, China, April 2009
    • Zhi Zhu, Haipeng Liu, Joseph Phillips, Weihong Tan. “Aptamer-crosslinked Target-responsive Hydrogel for Sensitive Visual Detection.” 60th Pittsburgh Conference, Chicago, IL, March 2009
    • Zhi Zhu,Zhiwen Tang, Weihong Tan. “Regulation of Singlet Oxygen Generation Using Aptamers and Single-walled Carbon Nanotubes.”1st Annual Nanoscience Technology Symposium, Orlando, FL, September 2008
    • Zhi Zhu,Hui William Chen, Weihong Tan. “Aptamer Conjugated Nanoparticles for Cancer Biomarker Studies.” 59th Pittsburgh Conference, New Orleans, LA, March 2008
    • Chen-jie Fang, Zhi Zhu, Chun-hua Yan. “Synthesis and Crystal Structure of Novel Cadmium(II) Complexes” 05-P-201, 5th Chinese NationalCoordination Chemistry Conference, Guangzhou, China, November2005

  • Leiji Zhou

    86-18750268060; ljzhou@xmu.edu.cn
    Working Experience______________________________________________________________

    • Aug 2005-present       Associate Professor, Department of Chemistry, Xiamen University
    • Mar 2003-Mar 2005    Postdoctoral Fellow,  College of Material Sciences and Engineering, Hunan Univ.

    EDUCATION____________________________________________________________________                                                        
    • Dept. Chem., Hunan Univ., Sept. 1998 - Jul. 2002, Ph.D,
       Advisor: Professor Kemin Wang.
    • Dept. Chem., Hunan Univ., Sept. 1995 - Jul. 1998, M.S.
      Advisor: Professor Kemin Wang.
    • Dept. Chem., Hunan Univ., Sept. 1989 - Jul. 1993 B.S.


    RESEARCH EXPERIENCE________________________________________________________
    2007-2010, National Natural Science Foundation of China (No. 20775065), PI

    2007-2010, Specialized Research Fund for the Doctoral Program of Higher Education (No. 20070384023), PI

    2008-2010, Specialized Fund for Agro-scientific Research in the Public Interest (200803033), PI
     
    Current Research:
    Chemo/bio-sensing and Biochips; Bio-analytical chemistry.

    HONORS AND AWARDS__________________________________________________________
    • 2003  The first prize for Progress in science and Technology in Hunan province

    PUBLICATIONS_________________________________________________________________
    • 1.      Xiao, Xifeng; Jiang, Xiaoqun, Zhou, Leiji. Surface Modification of Poly Ethylene Glycol to Resist Nonspecific Adsorption of Proteins, Chinese J of Anal Chem. 2013, 41 (3), 445-453.
      2.      Han, Da; Zhu, Zhi; Wu, Cuichen; Peng, Lu; Zhou, Leiji; Gulbakan, Basri; Zhu, Guizhi; Williams, Kathryn R.; Tan, Weihong. A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer-Protein Interactions, Journal of the American Chemical Society, 2012, 134, 20797-20804.
      3.      Zhou, Leiji; Wang, Kemin; Tan, Weihong; Chen, Yunqing; Zuo, Xinbing; Wen, Jianhui; Liu, Bin; Tang, Hongxing; He, Lifang; Yang, Xiaohai. Quantitative Intracellular Molecular Profiling Using a One-Dimensional Flow System, Analytical Chemistry, 2006, 78, 6246-6251.
      4.      Zhou, Leiji; Wang, Kemin; Choi, Martin M. F.; Xiao, Dan; Yang, Xiaohai; Chen, Rui; Tan, Weihong. Fiber-Optic Mode-Filtered Light Sensor for General and Rapid Chemical Assay, Measurement Science and Technology, 2004, 15, 137-142.
      5.      Zhou, Leiji; Wang, Kemin; Zuo, Xinbing; Choi, Martin M. F.; Chen, Yunqing; Huang, Shasheng. Mixed C18 and C1 Modification on an Optical Fiber for Chromatographic Sensing, Electrophoresis, 2003, 24, 3207-3211.
      6.      Zhang, He; Yang, Xiaohai; Wang, Kemin; Tan, Weihong; Zhou, Leiji; Zuo, Xinbing; Wen, Jianhui; Chen, Yunqing. Detection of Single-Base Mutations Using 1-D Microfluidic Beads Array, Electrophoresis, 2007, 28, 4668-4678.
      7.      Wen, Jianhui; Yang, Xiaohai; Wang, Kemin; Tan, Weihong; Zhou, Leiji; Zuo, Xinbing; Zhang, He; Chen, Yunqing. One-dimensional microfluidic beads array for multiple mRNAs expression detection, Biosensors and Bioelectronics, 2007, 22, 2759-2762.
      8.      Zuo, Xinbing; Yang, Xiaohai; Wang, Kemin; Tan, Weihong; Li, Huimin; Zhou, Leiji; Wen, Jianhui; Zhang, He. Improving the Performance of Immobilized Molecular Beacons through Cleavage, Analytica Chimica Acta, 2006, 567, 173-178.

  • Yanling Song

    Yanling Song

  • Wei Wang

    Education   
    PhD 
    Department of Biochemistry, University of Missouri, Columbia, U.S.   Sept 2008–July 2014   
                                          
    Bachelor of Medicine    
    School of Medicine, Shandong University, Jinan, China  Sept 2002–June 2008
                                          
    Work Experience
    Assistant professor
    Shanghai Jiao Tong University School of Medicine, Shanghai, China   Dec 2017- Present

    Postdoctoral fellow
    Peking University, Beijing, China    Apr 2015–Nov 2017

    Postdoctoral fellow
    University of Missouri, Columbia    Aug 2014–Jan 2015    
                                     
    Graduate research and teaching assistant
    University of Missouri, Columbia   Sept 2008–July 2014 
                                                                                                      
    Intern
    clinical training in Jinan Central Hospital, Jinan, China   Jan 2007–May 2008