Contact InformationYang's Laboratory
Room 532, Lujiaxi Building, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, ChinaPh: +86 (0) 592-218 7601
Professor, Principal Investigator
Dept. Chem., Xiamen Univ., Sept. 1994 - Jul. 1998 B.S.
Dept. Chem., Xiamen Univ., Sept. 1998 - Jul. 2001, M.S.
Department of Chemistry, University of Florida, USA. Aug.2001-Aug. 2006, Ph.D,
Postdoctoral Fellow, Department of Chemistry, University of California, Berkeley, 2006.9-2007.12, Advisor: Professor Richard Mathies.
Professor, Department of Chemical Biology, Xiamen University, 2008.1-
Advisory Board Member, Analyst, 2013.03
Associate Editor, BMC Biochemistry, 2013.07-
Editorial Advisory Board Member, Biomicrofluidics, 2015.01
Phone: +86 (0) 592-218 7601
Room 532, Lujiaxi Building, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
Honors and Awards:
Fellow of the Royal Society of Chemistry (2014)
Distinguished Young Investigator Award, National Science Foundation of China (2013)
Yunsheng Youth Scientific & Technical Award, Fujian Province (2013)
Distinguished Faculty Award,Chinese-American Chemistry & Chemical Biology Professors Association (2012)
Youth Medal, Fujian Province (2012)
Chinese Government Award for Outstanding Students Abroad (2006)
Sigma Xi Graduate Research Award, University of Florida (2006)
O’Neil Dissertation Fellowship, University of Florida (2005-2006)
American Chemical Society, DAC Graduate Fellowship (2005, Merck&Co.)
Major Research Grants:
2008-2010, Natural Science Foundation of Fujian Province (2008J0107), PI, Aptamers for Cancer Stem Cell Study
2009-2011, Research Fund for New Faculty of the Doctoral Program of Higher Education of China, PI, Microfluidics for Single Cell Gene Expression Study
2009-2011, Natural Science Foundation of China (20805038), PI, Molecular Tools for Living Cell mRNA Imaging
2010-2014, National Basic Research Program of China (973 Program, 2010CB732402), co-PI, Molecular Recognition Tools for Cancer Diagnosis
2011-2013, Natural Science Foundation of China (21075104), PI, Droplet Microfluidics for Single Cell Study
2011-2015, Ministry of Science and Technology (2011YQ3012412), co-PI, PERS for Cancer Imaging
2013-2016, Natural Science Foundation of China (21275122), PI, Aptamer Functionalized Microfluidic Devices for Circulating Tumor Cell Enrichment and Detection
2014-2015, Key Research Plan of Natural Science Foundation of China (91313302), co-PI, Small Molecular Probes for the Study of Signal Tranduction Pathways.
2014-2017, Distinguished Young Investigator Award (National Science Foundation of China) , PI, Bioanalytical Chemistry
Microfluidics, Molecular Recognitions, DNA Self-assembly, Early Diagnosis of Cancer,
1) We are establishing new microfluidic methods for high throughput single cell gene expression study and single cell protein counting, which will enable us to efficiently compare gene expression at both mRNA and protein level with single cell resolution from a large population of cells.
2) We are developing new molecular recognition ligands to recognize target proteins from single cells and cancer cells from a large population of normal cells with high selectivity. These ligands will be used for protein/cell imaging or protein/cell capture probes in single cell analysis.
3) DNA’s remarkable molecular recognition properties and structural features make it one of the most promising templates to pattern materials with nanoscale precision. We are exploring the feasibility of using the potent recognition capability of aptamers to construct DNA superstructures and explore their possible applications to disease diagnosis and therapy.
Integrating our microfluidic techniques, molecular recognition ligands and DNA nanostructures, we hope to develop new methods to address challenging problems of cancer diagnosis.