Chaoyong Yang

杨朝勇
Email: cyyang@xmu.edu.cn; chaoyongyang@gmail.com
Group Website: http://www.yang-lab.com/ & http://chem.xmu.edu.cn/teacher.asp?id=166
Phone Number: 0592-2187601

主要经历
————————————————————————————————————————————

 

• 2008年 8月至今，厦门大学特聘教授
• 2017年8月至今，上海交通大学分子医学研究院，教授、副院长
• 2015年8月至今，谱学分析与仪器教育部重点实验室，副主任
• 2010年11月至今，厦门大学药学院，兼职教授
• 2008年 1月至今，厦门大学化学生物学系，教授、博导
• 2008年11月至今，固体表面物理化学国家重点实验室，固定成员
• 2006年9月至2007年12月，加州大学伯克利分校化学系, 博士后, 导师: Richard Mathies
• 2001年8月至2006年8月，美国佛罗里达大学，生物分析化学博士，导师: 谭蔚泓
• 1994年9月至2001年7月，厦门大学化学系，本科，硕士，导师：王小如

 
研究兴趣
————————————————————————————————————————————

 

• 1. 体外诊断新技术
• 2. 细胞识别、富集与成像
• 3. 高通量单细胞测序
• 4. 微流控技术在生物医学中的应用
• 5.生物医学仪器

 
学术任职
————————————————————————————————————————————

• 中国化学会化学生物学专业委员会副主任
• 中国生物传感、生物芯片与纳米生物技术专业委员会委员
• 美国化学会ACS Applied Bio Materials副主编、BMC Biochemistry副主编、Scientific Reports 编委、美 国化学会期刊Analytical Chemistry 顾问编委、英国皇家化学会期刊Analyst、Lab on a Chip顾问编委、美国物理联合会期刊Biomicrofluidics 顾问编委、Journal of Analysis and Testing编委、《分析化学》编委。
• 厦门大学药学院、化学化工学院教授委员会委员

 
获奖情况
—————————————————————————————————————————————

• 美国化学会Advances in Measurement Science Lectureship Award (2021)
• 福建省科技进步一等奖（2020）
• 第五届中国化学会-英国皇家化学会青年化学奖(2016)
• 中组部、科技部等9部委《全民科学素质行动计划纲要》实施工作先进个人(2016)
• 福建省自然科学优秀学术论文一等奖(2016年)
• 科技部中青年科技创新领军人才(2015)
• 中国青年分析化学家奖 (2015年)
• 福建省青年科技奖 (2015)
• 厦门市科学技术进步奖二等奖 (2015)
• 福建省科学技术奖自然科学奖三等奖
• 福建省科技创新领军人才（2015）
• 福建省自然科学优秀学术论文一等奖(2014年)
• 福建省高校领军人才 (2014年)
• 厦门大学田昭武学科交叉奖一等奖(2014)
• 国家杰出青年科学基金(2013)
• 第二十届福建省运盛青年科技奖(2013)
• 第九届福建省五四青年奖章, (2012)
• 中美化学与化学生物学教授协会“杰出教授奖”(2012)
• 厦门大学“工商银行奖教金”(2011)
• 福建省杰出青年基金(2010)
• 2005年度中国国家优秀自费留学生奖 (2006)
• 美国佛罗里达大学Stasch 论文发表奖 (2006, 2007)
• 美国Sigma Xi 科研协会研究科研奖 (2006)
• 美国佛罗里达大学O’Neil 博士论文奖(2005-2006)
• 美国化学会分析化学研究生奖(2005)
• 美国宝洁科研奖(2005)
• 美国佛罗里达大学Herbert A. and Marjorie G. Laitinen 研究生奖(2005)
• 福建省优秀三好学生(2000)
• 厦门大学光华奖学金(1999, 2000)
• 厦门大学优秀三好学生、优秀学生干部(1997, 1998, 1999)
• 厦门大学化学化工学院傅鹰奖学金(1998)
• 厦门大学奖学金, (1995-1998)
• 福建省庄采芳奖学金(1994)

 
承担主要科研项目
————————————————————————————————————————————

• 国家重大科研仪器研制项目，21927806，自动化单细胞多组学分析系统, 2020年1月至2024年12月，645万，在研，主持
• 科技部国家重点研发计划合成生物学专项课题，2019YFA0905803，高通量DNA生物合成微流控模块研发, 2020年1月至2024年12月，506万，在研，主持。
• 国家自然科学基金委重点项目，21735004 ，循环肿瘤细胞高效分型捕获与高通量单细胞转录组测序分析，2018年01月 至2022年12月，300万，在研，主持。
• 国家自然科学基金委杰出青年基金，21325522，生物分析化学，2014/01-2017/12，320万，在研，结题（优秀）
• 国家自然科学基金委重大研究计划集成项，91313302，基于化学小分子探针的信号转导过程研究，2014/01-2015/12,  120万，已结题，参加
• 国家基金委面上项目，21275122， 核酸适体功能化微流控芯片用于循环肿瘤细胞的捕获富集检测, 2013/01-2016/12，80万，已结题
• 国家基金委面上项目，21075104， 液滴微流控技术用于高通量单细胞分析，2011/01-2013/12，37万，已结题，主持
• 科技部973课题，2010CB732402，核酸适体分子识别体系的设计与生物标志物的甄定，2010/01-2014/12，560万，已结题，主持
• 国家基金委青年基金，20805038, 用于细胞内基因成像的新型分子信标的设计与合成，2009/01-2011/12，22万，已结题，主持
• 教育部高博士学点基金(博导类), 外周血循环肿瘤细胞的识别、富集及单细胞水平表征新方法，2014-16年, 已结题，主持
• 科技部国家重大科学仪器设备开发专项，等离激元增强拉曼光谱仪器研发与应用，2011-10-01-2015-09- 30，已结题，主持
• 科技部973课题，增强拉曼光谱、电化学及联用技术应用于单细胞实时研究，2007-2011，已结题，主持
• 教育部留学回国人员科研启动基金，用于活细胞内mRNA成像的分子探针，2008-2010，已结题，主持
• 福建省自然科学基金，肿瘤干细胞的适体筛选及其在癌症研究和治疗的应用，2008-10年，已结题，主持
• 教育部博士点新教师基金，高通量单细胞基因分析的液滴微流控技术，2009-11年，已结题，主持
• 福建省杰出青年基金，肿瘤的早期诊断新方法研究，2010.6.1-2013.5.31已结题，主持

发表论文（Research ID: F-9741-2010, http://orcid.org/0000-0002-2374-5342）共发表SCI论文 202，论文被引 10400余次,  H index=55， 以第1作者或通讯作者发表SCI影响因子> 5.0的论文 97篇,  其中Nature Commun 3 篇、PNAS1 篇、Acc. Chem. Res.1篇、JACS  6 篇、Angew Chemie15 篇、AC28篇、Lab Chip10 篇、CC  14篇。
 
 

 

•  

 

Zhi Zhu

86-18750268060; zhuzhi8420@gmail.com; zhuzhi@xmu.edu.cn

Working Experience______________________________________________________________

• Aug 2015-present       Professor, Department of Chemical Biology, College of Chemistry and Chemical Engineering,  Xiamen University, Xiamen, China
• Jan 2012-present       Associate Professor, Department of Chemical Biology,College of Chemistry and

Chemical Engineering, Xiamen University, Xiamen, China

• Aug 2011-Jan 2012    Assistant Professor,  Department of Chemical Biology, College of Chemistry and

Chemical Engineering, Xiamen University, Xiamen, China
EDUCATION____________________________________________________________________                                                        

• University of Florida, Ph.D. in Analytical Chemistry,May 2011    Gainesville, FL   

Research Advisor: Dr. Weihong Tan

• Peking University,  B. S. Chemistry, 2006Beijing, China                           

Research Advisor: Dr. Chunhua Yan
RESEARCH EXPERIENCE________________________________________________________
2012-Present Associate Professor, Xiamen University                                                                          Xiamen, China
2011-2012Assistant Professor, Xiamen University         Xiamen, China

• DNA self-assembly and molecular engineering for cancer diagnosis
• Microfluidics for single molecule and single cell analysis

2007 – 2011Research Assistant, University of FloridaGainesville, FL 
(Supervisor: Dr. Weihong Tan)

• Functional-DNA cross-linked, target-responsive hydrogel for sensitive visual detection
• Molecular mediation of photodynamic therapyusing carbonnanomaterials

2006 – 2007 Teaching Assistant, University of Florida   Gainesville, FL
(Supervisor: Dr. James C. Horvath)

• Teaching assistant for general chemistry lab II

2004 – 2006Undergraduate Research Assistant, Peking University            Beijing, China
(Supervisor: Dr. Chunhua Yan)

• Synthesis and properties of tetrathiafulvalene derivative pending a fluorophore

HONORS AND AWARDS__________________________________________________________

• 2010    Chinese Government Award for Outstanding Students Aboard
• 2009    ACS Division of Analytical Chemistry Nine-Month Graduate Fellowship
• 2009   Roger G. Bates and Herbert A. Laitinen Fellowships, University of Florida
• 2008   Crow and Stasch Awards for excellence in scientific publication, University of Florida
• 2008 Honorary Mention for Poster Presentation at the 1^st Annual Nanoscience Technology Symposium held at

University of Central Florida

• 2007   Graduate Achievement Award, University of Florida
• 2006-present    Alumni Fellowship, University of Florida
• 2005    Xianglu Fellowship (for outstanding achievement, versatile personality and excellent studentwork),

Peking University

• 2004    Model of Outstanding Students, Peking University
• 2003    Second-class national Scholarship, Peking University

Xiyue Fellowship, Peking University

• 2002    First-class National Scholarship (for freshmen with excellent records in the entrance examination to

colleges and universities), Peking University
PUBLICATIONS_________________________________________________________________

• Ling Yan, Zhi Zhu, Yuan Zou, Yishun Huang, Dewen Liu, ShashaJia, DunmingXu, Min Wu, Yu Zhou, Shuang Zhou, Chaoyong James Yang. “Target-responsive ‘Sweet’ Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-glucose Targets.” Journal of the American Chemical Society,2013,DOI: 10.1021/ja3114714. (Co-first authors)
• Da Han,Zhi Zhu, Cuichen Wu, Lu Peng, Leiji Zhou, BasriGulbakan, Guizhi Zhu, Kathryn R. Williams, and Weihong Tan. “A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer–Protein Interactions.”Journal of the American Chemical Society,2012,134,20797-20804.(Co-first authors)
• Ling Zhu, Cong Li, Zhi Zhu, Dewen Liu, Yuan Zou, ChunmingWang, Hao Fu, Chaoyong James Yang. “In Vitro Selection of Highly Efficient G-Quadruplex-Based DNAzymes.”Analytical Chemistry, 2012,84, 8383-8390. (co-first authors)
• Jie Wu, Chi Wang, Xilan Li, Yanling Song, Wei Wang, Cong Li, Jia Hu, Zhi Zhu*, Jiuxing Li, Weiyun Zhang, Zhongxian Lu*, Chaoyong James Yang*. “Identification, Characterization and Application of a G-Quadruplex Structured DNA Aptamer against Cancer Biomarker Protein Anterior Gradient Homolog 2.”Plos One, 2012, 7, e46393.
• Cong Li, Ling Zhu, Zhi Zhu, Hao Fu, Gareth Jenkins, Chunming Wang, Yuan Zou, Xin Lu, Chaoyong James Yang. “Backbone Modification Promotes Peroxidase Activity of G-Quadruplex-Based DNAzyme.”Chem. Commun.,2012, 48,8347-8349. (co-first authors)
• Zhi Zhu, Wenhua Zhang, XuefeiLeng, Mingxia Zhang, Zhichao Guan and Chaoyong James Yang. “Highly Sensitive and Quantitative Detection of Rare Pathogens through Agarose Droplet Microfluidic Emulsion PCR at the Single-Cell Level.”Lab Chip, 2012, 12, 3907-3913.
• ZhiZhu, Gareth Jenkins, WenhuaZhang,Mingxia Zhang,ZhichaoGuan, Chaoyong James Yang. “Single-Molecule Emulsion PCR in Microfluidic Droplet.” Analytical Bioanalytical Chemistry, 2012,403, 2127-2143.
• Yanling Song, Weiting Zhang, Yuan An, Liang Cui, Chundong Yu,Zhi Zhu*, Chaoyong James Yang*. “Label-free visual detection of nucleic acids in biological samples with single-base mismatch detection capability.”Chem. Commun.,2012, 48, 576–578.
• Ying Pu, Zhi Zhu, Da Han, Huixia Liu, Jun Liu, Jie Liao, Kejing Zhang, Weihong Tan. “Insulin-Binding Aptamer-Conjugated Graphene Oxide for Insulin Detection.”Analyst, 2011,47, 4138-4140. (co-first authors)
• Chungming Wang, Zhi Zhu, Yanling Song, Hui Lin, Chaoyong James Yang, Weihong Tan. “Caged Molecular Beacons: Controlling Nucleic Acid Hybridization with Light.”Chem. Commun.,2011, 47, 5708-5710. (co-first authors)
• Zhi Zhu, Cuichen Wu, Haipeng Liu, Yuan Zou, Xiaoling Zhang, Huaizhi Kang, Chaoyong James Yang, Weihong Tan. “An Aptamer Cross-linked Hydrogel as a Colorimetric Platform for Visual Detection.” Angew. Chem. Int. Ed., 2010, 49, 1052-1056.
• Zhi Zhu, Ronghua Yang, Mingxu You, Xiaoling Zhang, Yanrong Wu, Weihong Tan. “Single-walled Carbon Nanotube as an Effective Quencher.” Analytical Bioanalytical Chemistry, 2010,396, 73-83.
• Zhi Zhu, Zhiwen Tang, Joseph A. Phillips, Ronghua Yang, Hui Wang, Weihong Tan. “Regulation of Singlet Oxygen Generation Using Single-Walled Carbon Nanotubes.”Journal of the American Chemical Society,2008, 130, 10856-10857.
• Tao Chen, CuichenSam Wu, Elizabeth Jimenez, Zhi Zhu, Joshua G. Dajac, Mingxu You, Da Han, Xiaobing Zhang and Weihong Tan. “DNA Micelle Flares for Intracellular mRNA Imaging and Gene Therapy.”Angew. Chem. Int. Ed.,2013, DOI: 10.1002/anie.201209440.
• GuoliangKe, Chunming Wang, Yun Ge, NanfengZheng, Zhi Zhu,Chaoyong James Yang. “L-DNA Molecular Beacon: A Safe, Stable, and Accurate Intracellular Nano-thermometer for Temperature Sensing in Living Cells.”Journal of the American Chemical Society,2012,134, 18908-18911.
• Xiaohong Tan, Tao Chen, Xiangling Xiong, Ye Mao, Guizhi Zhu, Emir Yasun, Chunmei Li, Zhi Zhu, Weihong Tan. “Semiquantification of ATP in Live Cells Using Nonspecific Desorption of DNA from Graphene Oxide as the Internal Reference.”Analytical Chemistry, 2012,84, 8622-8627.
• Xiaohong Tan, Weijun Chen, Shun Lu, Zhi Zhu, Tao Chen, Guizhi Zhu, Mingxu You, Weihong Tan. “Molecular Beacon Aptamers for Direct and Universal Quantitation of Recombinant Proteins from Cell Lysates.”Analytical Chemistry, 2012,84, 8272-8276.
• Dezhi Kang, Jiangjie Wang, Weiyun Zhang, Yanling Song, Xilan Li, Yuan Zou, Mingtao Zhu,Zhi Zhu, Fuyong Chen, Chaoyong James Yang. “Selection of DNA Aptamers against Glioblastoma Cells with High Affinity and Specificity.”Plos One, 2012, 7, e42731.
• Xue-Qin Zhao, Jie Wu, Jing-Hong Liang, Jia-Wei Yan, Zhi Zhu, Chaoyong James Yang, Bing-Wei Mao. “Single-Molecule Force Spectroscopic Studies on Intra- and Intermolecular Interactions of G-Quadruplex Aptamer with Target Shp2 Protein.”Journal of Physical ChemistryB, 2012, 116, 11397-11404.
• Liang Cui, Yuan Zou, Ninghang Lin, Zhi Zhu, Gareth Jenkins, Chaoyong James Yang. “Mass Amplifying Probe for Sensitive Fluorescence Anisotropy Detection of Small Molecules in Complex Biological Samples.”Analytical Chemistry, 2012,84, 5535-5541.
• HuifaZhang, Gareth Jenkins, Yuan Zou,ZhiZhu, Chaoyong James Yang. “Massively Parallel Single-Molecule and Single-Cell Emulsion Reverse Transcription Polymerase Chain Reaction Using Agarose Droplet Microfluidics.”Analytical Chemistry, 2012,84, 3599-3606.
• Lu Peng, Zhi Zhu, Yan Chen, Da Han, Weihong Tan. “An Exonuclease III and GrapheneOxide-Aided Assay for DNA Detection.”Biosensors Bioelectronics, 2012,35, 475-478.
• Mohammed I.Shukoor,  Meghan O.Altman, Da Han,Abdullah TahirBayrac, Ismail Ocsoy,ZhiZhu, WeihongTan. “Aptamer-Nanoparticle Assembly for Logic-Based Detection.”ACS Applied Materials & Interfaces, 2012,4, 3007-3011.
• Jian Wang, Guizhi Zhu, Mingxu You, Erqun Song, Mohammed I.Shukoor, Kejing Zhang, Meghan O.Altman, Yan Chen, Zhi Zhu, Cheng Zhi Huang, Weihong Tan. “Assembly of Aptamer Switch Probes and Photosensitizer on Gold Nanorods for Targeted Photothermal and Photodynamic Cancer Therapy.”ACS Nano, 2012, 6, 5070-5077.
• Bin-Cheng Yin, Bang-Ce Ye, Hui Wang, Zhi Zhu, Weihong Tan. “Colorimetric logic gates based on aptamer-crosslinked hydrogels.”Chem. Commun.,2012, 48, 1248–1250.
• Weiyun Zhang, Wenhua Zhang, Zhiyuan Liu, Cong Li, Zhi Zhu, Chaoyong Yang. “Highly Parallel Single-Molecule Amplification Approach Based on Agarose Droplet Polymerase Chain Reaction for Efficient and Cost-Effective Aptamer Selection.”Analytical Chemistry,2012, 84, 350-355.
• Liang Cui, Xiaoyan Lin, Ninghang Lin, Yanling Song,Zhi Zhu, Xi Chen, Chaoyong James Yang. “Graphene oxide-protected DNA probes for multiplex microRNA analysis in complex biological samples based on a cyclic enzymatic amplification method.”Chem.Commun.,2012, 48, 194-196.
• Jun Liu, Huixia Liu, Huaizhi Kang, Michael Donovan, Zhi Zhu, Weihong Tan. “Aptamer-incorporated hydrogels for visual detection, controlled drug release, and targeted cancer therapy.”Analytical Bioanalytical Chemistry, 2012,402, 187-194.
• Kelong Wang, Mingxu You, Yan Chen, Da Han, Zhi Zhu, Jin Huang, Kathryn William, Chaoyong James Yang, Weihong Tan. “Self-assembly of aBifunctionalDNA Carrier for Drug Delivery.”Angew. Chem. Int. Ed.,2011, 50,6098-6101.
• Da Han, Jin Huang, Zhi Zhu, Quan Yuan, Mingxu You, Yan Chen and Weihong Tan. “Molecular Engineering of Photoresponsive Three-dimensional DNA Nanostructures.” Chem. Commun.,2011,47, 4670-4672.
• Jin Huang, Yan Chen, Liu Yang,Zhi Zhu, Guizhi Zhu, Xiaohai Yang, Kemin Wang, Weihong Tan. “Amplified detection of cocaine based on strand-displacement polymerizationand fluorescence resonance energy transfer.”Biosensors Bioelectronics, 2011,28, 450-453.
• Zhuo Chen, Xiaobing Zhang, Ronghua Yang, Zhi Zhu, Yan Chen and Weihong Tan. “Single-walled Carbon Nanotubes as Optical Materials for Biosensing.” Nanoscale,2011,3, 1949-1956.
• Jin Huang, Yanrong Wu, Yan Chen, Zhi Zhu, Xiaohai Yang, Chaoyong James Yang, Kemin Wang and Weihong Tan. “Pyrene-Excimer Probes Based on the Hybridization Chain Reaction for the Detection of Nucleic Acids in Complex Biological Fluids.” Angew. Chem. Int. Ed.,2011, 50, 401-404.
• Huaizhi Kang, Haipeng Liu, Xiaoling Zhang, Jilin Yan, Zhi Zhu, Lu Peng, Huanghao Yang, Youngmi Kim, Weihong Tan. “Photoresponsive DNA-Cross-Linked Hydrogels for Controllable Release and Cancer Therapy.”Langmuir, 2011,27, 399-408.
• Yamin Li, Xiaoling Zhang, Baocun Zhu, Juan Xue, Zhi Zhu, Weihong Tan. “A Simple but Highly Sensitive and Selective Colorimetric and Fluorescent Probe for Cu²⁺ in Aqueous Media.” Analyst, 2011,136, 1124-1128.
• Tao Chen, Mohammed Ibrahim Shukoor, Yan Chen, Quan Yuan, Zhi Zhu,Zilong Zhao, BasriGulbakan, Weihong Tan. “Aptamer-conjugated Nanomaterials for Bioanalysis and Biotechnology Applications.” Nanoscale, 2011, 3, 546-556.
• Ying Pu, Zhi Zhu, Huixia Liu, Jiani Zhang, Jun Liu, Weihong Tan. “Using Aptamers to Visualize and Capture Cancer Cells.” Analytical Bioanalytical Chemistry,2010, 397, 3225-3233.
• Jin Huang, Zhi Zhu, SuwussaBamrungsap, Guizhi Zhu, Mingxu You, Xiaoxiao He, Kemin Wang, Weihong Tan. “Competition-Mediated Pyrene-Switching Aptasensor: Probing Lysozyme in Human Serum with a Monomer-Excimer Fluorescence Switch.”Analytical Chemistry, 2010,82, 10158-10163.
• Basri Gulbakan, Emir Yasun, M. Ibrahim Shukoor, Zhi Zhu, Mingxu You, Xiaohong Tan, Hernan Sanchez, David H. Powell, Hongjie Dai, Weihong Tan.“A Dual Platform for Selective Analyte Enrichment and Ionization in Mass Spectrometry Using Aptamer-Conjugated Graphene Oxide.”Journal of the American Chemical Society, 2010,132, 17408-17410.
• Mingxu You, Zhi Zhu,Haipeng Liu, BasriGulbakan, Da Han, Ruoren Wang, Kathryn R. Williams, Weihong Tan. “Pyrene-Assisted Efficient Photolysis of Disulfide Bonds in DNA-Based Molecular Engineering.”ACS Applied Materials & Interfaces, 2010,2, 3601-3605.
• Haipeng Liu, Zhi Zhu, Huaizhi Kang, Yanrong Wu, Kwame Sefan, Weihong Tan.“DNA-Based Micelles: Synthesis, Micellar Properties and Size-Dependent Cell Permeability.”Chemistry--A European Journal,2010, 16, 3791-3797,
• Zhiwen Tang, Zhi Zhu, PrabodhikaMallikaratchy, Ronghua Yang, Kwame Sefah, Weihong Tan. “Aptamer-Target Binding Triggered Molecular Mediation of Singlet Oxygen Generation.”Chemistry--An Asian Journal,2010, 5, 783-786.
• Yan Liu; Se Won Bae, Kelong Wang, Jong-In Hong, Zhi Zhu, Weihong Tan, Dimitri Pappas. “The Effects of Flow Type on Aptamer Capture in Differential Mobility Cytometry Cell Separations.” AnalyticaChimicaActa,2010, 673, 95-100.
• Xiaolan Chen, M.-Carmen Estevez, Zhi Zhu, Yu-fen Huang, Yan Chen, Lin Wang, Weihong Tan. “Using Aptamer-Conjugated Fluorescence Resonance Energy Transfer Nanoparticles for Multiplexed Cancer Cell Monitoring.”Analytical Chemistry, 2009, 81,7009-7014.
• Hui Wang, Youngmi Kim, Haipeng Liu, Zhi Zhu, Suwussa Bamrungsap, Weihong Tan.  “Engineering a Unimolecular DNA-Catalytic Probe for Single Lead Ion Monitoring.”Journal of the American Chemical Society,2009,131, 8221-8226.
• Yan Chen, Alina C. Munteanu, Yu-Fen Huang, Joseph Phillips,Zhi Zhu, Michael Mavros, Weihong Tan. “Mapping Receptor Density on Live Cells Using Fluorescence Correlation Spectroscopy.”Chemistry-A European Journal, 2009, 15, 5327-5336.
• Zhiwen Tang,PrabodhikaMallikaratchy, Ronghua Yang,Youngmi Kim, Zhi Zhu,Hui Wang,Weihong Tan. “Aptamer Switch Probe Based on Intramolecular Displacement.”Journal of the American Chemical Society,2008,130, 11268-11269.
• Ronghua Yang, Jianyu Jin, Yan Chen, Na Shao, Huaizhi Kang, Zeyu Xiao, Zhiwen Tang, Yanrong Wu, Zhi Zhu, Weihong Tan.“Carbon Nanotube-Quenched Fluorescent Oligonucleotides: Probes that Fluoresce upon Hybridization.”Journal of the American Chemical Society, 2008,130, 8351-8358.
• Joseph A. Phillips, Dalia Colon-Lopez, Zhi Zhu, Ye Xu, Weihong Tan. “Applications of Aptamers in Cancer Cell Biology.” AnalyticaChimicaActa, 2008,621, 101-108.
• Ronghua Yang,Zhiwen Tang,Jilin Yan, Huaizhi Kang,Youngmi Kim,Zhi Zhu,Weihong Tan.   “Noncovalent Assembly of Carbon Nanotubes and Single-Stranded DNA: An Effective Sensing Platform for Probing Biomolecular Interactions.” Analytical Chemistry,2008, 80, 7408-7413.
• Wei Sun, Chun-Hu Xu, Zhi Zhu, Chen-Jie Fang, and Chun-Hua Yan.“Chemical-Driven Reconfigurable Arithmetic Functionalities within a Fluorescent Tetrathiafulvalene Derivative.” Journal of Physical Chemistry C, 2008,112, 16973-16983.
• Chen-Jie Fang, Zhi Zhu, Wei Sun, Chun-Hu Xu, Chun-Hua Yan. “New TTF derivatives: Several molecular logic gates based on their switchable fluorescent emissions.”New Journal of Chemistry, 2007, 31, 580-586.

PRESENTATIONS_______________________________________________________________

• Zhi Zhu. “Portable and Quantitative Detection Platform Based on Functional DNA Crosslinked Hydrogel.”5^thInternational Symposium on Biomedical Engineering, Bioanalysis and Nanotechnology, Changsha, China, June, 2012
• Zhi Zhu. “Carbon Nanomaterials as Effective Quenchers for Biosensing and Targeted Therapy.”3rd Asian Spectroscopy Conference, Xiamen, China, November 2011
• Zhi Zhu, Jin Huang, Xiangling Xiong, Weihong Tan. “mRNA/Graphene oxide for molecular mediation of photodynamic therapy. ” 241^st ACS National Meeting & Exposition, Anaheim, CA, March 2011
• Zhi Zhu, Mohammed Ibrahim Shukoor, Weihong Tan. “Logic Switchboard for Medical Diagnosis.”62^ndPittsburgh Conference, Atlanta, GA, March 2011
• Zhi Zhu, Haipeng Liu, Chaoyong James Yang, Weihong Tan.“Functional DNA cross-linked hydrogel for visual detection.”Gordon Research Conference 2010, Bioanalytical Sensors, New London, NH, June 2010
• Zhi Zhu, Weihong Tan. “Aptamer-switches for Bioanalytical and Biomedical Applications.” Invited Seminar, Proctor & Gamble, Cincinnati, OH, March2010
• Zhi Zhu, Haipeng Liu, Chaoyong Yang, Weihong Tan. “Aptamer cross-linked Hydrogel for Visual Detection.” 61^stPittsburgh Conference, Orlando, FL, March2010
• Zhi Zhu, Weihong Tan. “Target-responsive Aptamer-switches for Bioanalytical and Biomedical Applications.” Invited Seminar, Xiamen University, China, April 2009
• Zhi Zhu, Haipeng Liu, Joseph Phillips, Weihong Tan. “Aptamer-crosslinked Target-responsive Hydrogel for Sensitive Visual Detection.” 60^th Pittsburgh Conference, Chicago, IL, March 2009
• Zhi Zhu,Zhiwen Tang, Weihong Tan. “Regulation of Singlet Oxygen Generation Using Aptamers and Single-walled Carbon Nanotubes.”1^st Annual Nanoscience Technology Symposium, Orlando, FL, September 2008
• Zhi Zhu,Hui William Chen, Weihong Tan. “Aptamer Conjugated Nanoparticles for Cancer Biomarker Studies.” 59^th Pittsburgh Conference, New Orleans, LA, March 2008
• Chen-jie Fang, Zhi Zhu, Chun-hua Yan. “Synthesis and Crystal Structure of Novel Cadmium(II) Complexes” 05-P-201, 5^th Chinese NationalCoordination Chemistry Conference, Guangzhou, China, November2005

Peng Zhang

Peng Zhang

Yanling Song

个人简历：

副教授、特任研究员 （厦门大学化学系 2019.11–至今）

特任副研究员/副研究员 （上海交通大学分子医学研究院2018–2019）

助理研究员 （福州大学生物科学与工程学院2016–2018）

理学博士 （厦门大学化学系化学生物学专业 2010–2016）

理学学士 （厦门大学化学系化学生物学专业 2006–2010）

获得荣誉：

厦门大学“南强青年拔尖人才支持计划”（2019）

上海市“晨光计划”A类（2018）

 

研究兴趣：
分子定向进化、微纳界面组装及识别机制、微流控分析、液体活检、单细胞分析、生物传感

近期主要代表论著：

1. 1. Jialu Zhang, Bingqian Lin, Lingling Wu, Mengjiao Huang, Xingrui Li, Huimin Zhang, Jia Song, Wei Wang, Gang Zhao,* Yanling Song,* and Chaoyong Yang*, DNA Nanolithography Enables Highly Ordered Recognition Interface in Microfluidic Chip for Efficient Capture and Release of Circulating Tumor Cells, Angew. Chem. Int. Ed. 2020, DOI: 10.1002/anie.202005974

2. 2. M.J. Huang, J.J. Yang, T. Wang, J. Song, J.L. Xia, L.L. Wu, W. Wang, Q.Y. Wu, Z. Zhu, Y.L. Song*, C.Y. Yang*, Homogeneous, Low-volume, Efficient and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction. Angew. Chem. Int. Ed doi.org/10.1002/anie.201916039(2020)

3. 3. L.L. Wu, ^# H.M. Ding, ^# X. Qu, ^# X.A. Shi, J.M.Yang, M.J. Huang, J.L. Zhang, H.M. Zhang, J. Song, L. Zhu, Y.L. Song*, Y.Q. Ma*, C.Y. Yang*, Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability, J. Am. Chem. Soc. doi.org/10.1021/jacs.9b13782(2020)

4. 4. J. Song, Y. Zheng, M.J. Huang, L.L. Wu, W. Wang, Z. Zhu, Y.L. Song*, C.Y. Yang, A Sequential Multi-dimensional Analysis Algorithm for Aptamer Identification based on Structure Analysis and Machine Learning. Anal. Chem. doi.org/10.1021/acs.analchem.9b05203(2020)

5. 5. Y.L. Song; Y.Z. Shi; M.J. Huang; W. Wang; Y. Wang; J.Cheng.; Z.C. Lei; Z. Zhu.; C.Y. Yang*, Bioinspired Engineering of a Multivalent Aptamer-Functionalized Nanointerface to Enhance the Capture and Release of Circulating Tumor Cells. Angew. Chem. Int. Ed. 58(8), 2236(2019)

6. 6. M.J. Huang, J. Song, P.F. Huang, X.F. Chen, W. Wang, Z. Zhu, Y.L. Song*, C.Y. Yang*. Molecular Crowding Evolution for Enabling Discovery of Enthalpy-Driven Aptamers for Robust Biomedical Applications. Anal. Chem. 91, 10879(2019)

7. 7. B.Q. Lin ^#, Y. An^#, L.Y. Meng, H.M. Zhang, J. Song, Z. Zhu, W. Liu*, Y.L. Song*, C.Y. Yang*. Control of CRISPR-Cas9 with small molecule-activated allosteric aptamer regulating sgRNAs. Chem. Commun., 55, 12223(2019)

8. 8. Y.L. Song; B.Q. Lin; Tian, T.; X. Xu; W. Wang; Q.Y. Ruan; J.J. Guo; Z. Zhu; C.Y. Yang*, Recent Progress in Microfluidics-Based Biosensing. Analytical Chemistry 91 (1), 388(2019)

9. 9. M.X. Gao; J.J. Guo; Y.L. Song *; Z. Zhu*; C.Y. Yang*. Detection of T4 Polynucleotide Kinase via Allosteric Aptamer Probe Platform, ACS Appl. Mater. Interfaces, 9, 38356(2017)

10. 10. Y.L. Song; Tian, T; Y.Z Shi; W.L. Liu; Y. Zou, T. Khajavand; Z. Zhu; C.Y. Yang*. Enrichment and Single-Cell Analysis of Circulating Tumor Cells, Chemical Science, 8, 1736(2017)

11. 11. Tian, T; Y. An; Y. Wu; Y.L. Song*; Z. Zhu; C.Y. Yang*. Integrated Distance-Based Origami Paper Analytical Device for One-Step Visualized Analysis, ACS Applied Materials Interfaces, 9, 30480(2017)

Leiji Zhou

86-18750268060; ljzhou@xmu.edu.cn
Working Experience______________________________________________________________

• Aug 2005-present       Associate Professor, Department of Chemistry, Xiamen University

• Mar 2003-Mar 2005    Postdoctoral Fellow,  College of Material Sciences and Engineering, Hunan Univ.

EDUCATION____________________________________________________________________                                                        

• Dept. Chem., Hunan Univ., Sept. 1998 - Jul. 2002, Ph.D,
   Advisor: Professor Kemin Wang.

• Dept. Chem., Hunan Univ., Sept. 1995 - Jul. 1998, M.S.
  Advisor: Professor Kemin Wang.
• Dept. Chem., Hunan Univ., Sept. 1989 - Jul. 1993 B.S.

RESEARCH EXPERIENCE________________________________________________________
2007-2010, National Natural Science Foundation of China (No. 20775065), PI

2007-2010, Specialized Research Fund for the Doctoral Program of Higher Education (No. 20070384023), PI

2008-2010, Specialized Fund for Agro-scientific Research in the Public Interest (200803033), PI
 
Current Research:
Chemo/bio-sensing and Biochips; Bio-analytical chemistry.

HONORS AND AWARDS__________________________________________________________

• 2003  The first prize for Progress in science and Technology in Hunan province

PUBLICATIONS_________________________________________________________________

• 1.      Xiao, Xifeng; Jiang, Xiaoqun, Zhou, Leiji. Surface Modification of Poly Ethylene Glycol to Resist Nonspecific Adsorption of Proteins, Chinese J of Anal Chem. 2013, 41 (3), 445-453.
  2.      Han, Da; Zhu, Zhi; Wu, Cuichen; Peng, Lu; Zhou, Leiji; Gulbakan, Basri; Zhu, Guizhi; Williams, Kathryn R.; Tan, Weihong. A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer-Protein Interactions, Journal of the American Chemical Society, 2012, 134, 20797-20804.
  3.      Zhou, Leiji; Wang, Kemin; Tan, Weihong; Chen, Yunqing; Zuo, Xinbing; Wen, Jianhui; Liu, Bin; Tang, Hongxing; He, Lifang; Yang, Xiaohai. Quantitative Intracellular Molecular Profiling Using a One-Dimensional Flow System, Analytical Chemistry, 2006, 78, 6246-6251.
  4.      Zhou, Leiji; Wang, Kemin; Choi, Martin M. F.; Xiao, Dan; Yang, Xiaohai; Chen, Rui; Tan, Weihong. Fiber-Optic Mode-Filtered Light Sensor for General and Rapid Chemical Assay, Measurement Science and Technology, 2004, 15, 137-142.
  5.      Zhou, Leiji; Wang, Kemin; Zuo, Xinbing; Choi, Martin M. F.; Chen, Yunqing; Huang, Shasheng. Mixed C18 and C1 Modification on an Optical Fiber for Chromatographic Sensing, Electrophoresis, 2003, 24, 3207-3211.
  6.      Zhang, He; Yang, Xiaohai; Wang, Kemin; Tan, Weihong; Zhou, Leiji; Zuo, Xinbing; Wen, Jianhui; Chen, Yunqing. Detection of Single-Base Mutations Using 1-D Microfluidic Beads Array, Electrophoresis, 2007, 28, 4668-4678.
  7.      Wen, Jianhui; Yang, Xiaohai; Wang, Kemin; Tan, Weihong; Zhou, Leiji; Zuo, Xinbing; Zhang, He; Chen, Yunqing. One-dimensional microfluidic beads array for multiple mRNAs expression detection, Biosensors and Bioelectronics, 2007, 22, 2759-2762.
  8.      Zuo, Xinbing; Yang, Xiaohai; Wang, Kemin; Tan, Weihong; Li, Huimin; Zhou, Leiji; Wen, Jianhui; Zhang, He. Improving the Performance of Immobilized Molecular Beacons through Cleavage, Analytica Chimica Acta, 2006, 567, 173-178.

Lingling Wu

86-18717959686; linglingwu1990@126.com

Work Experience                                                         ____________________________________________________
Jul 2020-Present Assistant professor, Institute of Molecular Medicine, Shanghai Jiao Tong University, Shanghai, China
Jul 2018-Jun 2020 Postdoctoral fellow, Institute of Molecular Medicine, Shanghai Jiao Tong University, Shanghai, China
 
Education                                                            ___________________________________________________________
Sep 2011-Jun 2018 Ph.D. in Analytical Chemistry, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China
Research Advisor: Dr. Dai-Wen Pang
Sep 2007-Jun 2011 B. S. of Pharmaceutical Engineering, Northwest Agriculture & Forestry University, Xi'an, China
 
Honors and Awards                                                       _________________________________________________
2018  Outstanding graduate of Wuhan University
2014  National Scholarship for Doctoral Candidate
2008  National Scholarship
 
Publications                                                           ________________________________________________________
1. Wu, L. L.,^# Zhang, Z. L., Tang, M., Zhu, D. L., Dong, X. L., Hu, J., Qi, C. B., Tang, H. W., Pang, D. W., * Spectrally Combined Encoding for Profiling Heterogeneous Circulating Tumor Cells Using a Multifunctional Nanosphere-Mediated Microfluidic Platform. Angew. Chem. Int. Ed. 2020, 59, 11240.
2. Wu, L. L.,^# Ding, H. M., ^# Qu, X., ^# Shi, X. N., Yang, J. M., Huang, M. J., Zhang, J. L., Zhang, H. M.; Song, J., Zhu, L., Song, Y. L., * Ma, Y. Q., * Yang, C. Y.,* Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability. J. Am. Chem. Soc. 2020, 142, 4800.
3. Wu, L. L., Wang, Y. D., Zhu, L., Liu, Y. L., Wang, T., Liu, D., Song, Y. L., Yang, C. Y.,* Aptamer-Based Liquid Biopsy. ACS Appl. Bio Mater. 2020, 3, 2743.
4. Wu, L. L.,^# Zhu, L., Huang, M. J., Song, J., Zhang, H. M, Song, Y. L., Wang, W., Yang, C. Y., * Aptamer-Based Microfluidics for Isolation, Release and Analysis of Circulating Tumor Cells. TrAC, Trends Anal. Chem. 2019, 117, 69.
5. Wu, L. L,^# Xu, X., Sharma, B., Wang, W., Qu, X., Zhu, L., Zhang, H. M., Song, Y. L., Yang, C. Y.,* Beyond Capture: Circulating Tumor Cell Release and Single-cell Analysis. Small Methods 2019, 3, 1800544.
6. Wu, L. L,^# Tang, M., Zhang, Z. L., Qi, C. B., Hu, J., Ma, X. Y., Pang, D. W.,* Chip-Assisted Single-Cell Biomarker Profiling of Heterogeneous Circulating Tumor Cells Using Multifunctional Nanospheres. Anal. Chem. 2018, 90, 10518.
7. Wu, L. L.,^# Wen, C. Y., Hu, J., Tang, M., Qi, C. B., Li, N., Liu, C., Chen, L., Pang, D. W., Zhang, Z. L.,* Nanosphere-Based One-Step Strategy for Efficient and Nondestructive Detection of Circulating Tumor Cells.  Biosens. Bioelectron. 2017, 94, 219.
8. Ma, X. Y.,^# Wu. L. L.,^# Chen, L., Qin, Y. H., Hu, J., Tang, M., Xu, C. M., Qi, C. B., Zhang, Z. L., Pang, D. W.,* Enhanced and High-Purity Enrichment of Circulating Tumor Cells Based on Immunomagnetic Nanospheres. ACS Appl. Nano Mater. 2018, 1, 4019. (Co-first author)
9. Chen, L.,^# Wu, L. L., ^# Zhang, Z. L., Hu, J., Tang, M., Qi, C. B., Li, N., Pang, D. W.,* Biofunctionalized Magnetic Nanospheres-Based Cell Sorting Strategy for Efficient Isolation, Detection and Subtype Analyses of Heterogeneous Circulating Hepatocellular Carcinoma Cells. Biosens. Bioelectron. 2016, 85, 633. (Co-first author)
10. Wen, C. Y.,^# Wu, L. L.,^# Zhang, Z. L., Hu, J., Tang, M., Sun, E. Z., Gong, Y. P., Yu, J., Pang, D. W.,* Quick-Response Magnetic Nanospheres for Rapid, Efficient Capture and Sensitive Detection of Circulating Tumor Cells. ACS Nano 2014, 8, 941. (Co-first author)

Huimin Zhang

86-15859257624; zhanghuimin2017@foxmail.com

Work Experience                                                         ____________________________________________________
Jul 2020-Present Associate professor, Tan Kah Kee Innovation Laboratory, Xiamen University, Xiamen, China
Jul 2018-Jun 2020 Postdoctoral fellow, Institute of Molecular Medicine, Shanghai Jiao Tong University, Shanghai, China
 
Education                                                            ___________________________________________________________
Sep 2012-Jun 2018 Ph.D., Department of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China
Aug 2014-Dec 2015 Visiting Fellow, NIBIB, National Institutes of Health
Sep 2008-Jun 2012 B. S.,  College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, China
 
Honors and Awards                                                       _________________________________________________
2019  Second-class outstanding award of The 8^th China Innovation and Entrepreneurship Competition
2019  Postdoctoral Incentive Program of Shanghai Jiao Tong University School of Medicine
2015  Xiamen Airline Scholarship of Xiamen University
2015, 2016 Merit Student Award of Xiamen University
 
Publications                                                           ________________________________________________________
1. Zhang, H^#; Yang, Y^#; Liu, Y; Wang, Y; Ruan, W; Song, J; Yu, X; Wu, L; Zhu, Z; Hong, G*; Yang, C*; Stimuli-Responsive Microfluidic Interface Enables Highly Efficient Capture and Release of Circulating Fetal Cells for Non-Invasive Prenatal Testing, Anal Chem, 2020, 92, 13, 9281-9286.
2. Liu, Y; Zhang, H*; Du, Y; Zhu Z; Zhang, M; Lv, Z; Wu, L; Yang, Y; Li, A; Yang, L; Song, Y; Wang, S*; Yang, C*, Highly sensitive minimal residual disease detection by biomimetic multivalent aptamer nanoclimber functionalized microfluidic chip. Small, 2020, 2000949.
3. Zhang, H; Wu, L; Lin, B; Wang, Y; Bi, Y; Wang, W; Song, Y;Yang, C*, Recent progress on microfluidic technology-based circulating tumor cell analysis. SCIENTIA SINICA Chimica, 2019, 1220-1236.
4. Zhang, H;Yang, Y; Li, X; Shi, Y; Hu, B; An, Y; Zhu, Z; Hong, G; Yang, C*, Frequency-enhanced transferrin receptor antibody-labelled microfluidic chip (FETAL-Chip) enables efficient enrichment of circulating nucleated red blood cells for non-invasive prenatal diagnosis. Lab Chip, 2018,18, 2749-2756
5. Zhang, H; Zhou, L; Zhu, Z; Yang, C*. Recent Progress in Aptamer-Based Functional Probes for Bioanalysis and Biomedicine. Chemistry - A European Journal. 2016, 22(29):9886-9900
6. Zhang, H;Ma, Y; Xie, Y; An, Y; Huang, Y; Zhu, Z; Yang, C*, A controllable aptamer-based self-assembled DNA dendrimer for high affinity targeting, bioimaging and drug delivery. Sci Rep. 2015, 5:10099 (cited by 65)
7. Zhang, H;Song, Y; Zou, Y; Ge, Y; Zhu Z* and Yang, C*. A diazirine-based photocrosslinking probe for facile and efficient aptamer-protein covalent conjugation. Chem Commun. 2014, 50(38):4891-4894
8. Li, X; Zhang, D; Zhang, H; Guan, Z; Song, Y; Liu, R; Zhu, Z and Yang, C*. A microwell array method for rapid generation of uniform agarose droplets and beads for single molecule analysis.Anal. Chem., 2018, 90(4):2570-2577
9. Yang, X; Liu, Z; Zhang, H; Li, Z; Munasinghe JP; Niu, G; Teng, G; Chen, X*. Preclinical evaluation of an 18F-trifluoroborate methionine derivative for glioma imaging. Eur J Nucl Med Mol Imaging., 2018, 45(4):585-592
10. Liu, D; Jia, S; Zhang, H; Ma, Y; Guan, Z; Li, J; Zhu, Z*; Ji, T; Yang, C*. Integrating target-responsive hydrogel with pressuremeter readout enables simple, sensitive, user-friendly, quantitative point-of-care testing. ACS Appl. Mater. Interfaces, 2017, 9 (27), 22252–22258
11. Zhu, G; Zhang, H; Jacobson, O; Wang, Z, Chen, H, Yang, X, Niu, G; Chen, X*. Combinatorial Screening of DNA Aptamers for Molecular Imaging of HER2 in Cancer. Bioconjug Chem. 2017, 28(4):1068-1075
12. Lin, B; An, Y; Meng, L; Zhang, H; Song, J; Zhu, Z; Liu, W; Song, Y; Yang, C*. Control of CRISPR-Cas9 with small molecule-activated allosteric aptamer regulating sgRNAs. Chem. Commun., 2019, 55, 12223-12226.
13. Wu, L; Zhu, L; Huang, M; Song, J; Zhang, H; Song, Y; Wang, W; Yang, C*. Aptamer-based microfluidics for isolation, release and analysis of circulating tumor cells. Trends Anal. Chem., 2019, 117, 69-77.
14. Wu, L; Ding, H; Qu, X; Shi, X; Yang, J; Huang, M; Zhang, J; Zhang, H; Song, J; Zhu, L; Song, Y*; Ma, Y*; Yang, C*. Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability, J. Am. Chem. Soc. 2020, 142, 4800-4806.

Jia Song

上海交通大学, 医学院-新华医院, 课题组PI

教育经历:

(1) 2013-09 至 2018-06, 北京师范大学, 生物信息, 博士

(2) 2009-09 至 2013-06, 兰州大学, 数学与应用数学, 学士

博士后工作经历:

(1) 2018-08 至 2020-08, 上海交通大学，医学院-仁济医院

科研与学术工作经历:

 

在过去的五年里，以第一或通讯作者身份发表了24篇学术论文，包括1篇Nat. Biotechnol.、3篇Nat. Commun.、2篇Proc. Natl. Acad. Sci. U. S. A等。

1.Jiao Cao#; Zhong Zheng#; Di Sun#; Xin Chen; Rui Cheng; Tianpeng Lv; Yu An; Junhua Zheng*; Jia Song*; Lingling Wu*; Chaoyong Yang*; Decoder-seq enhances mRNA capture efficiency in spatial RNA sequencing，Nature Biotechnology,  2024. https://doi.org/10.1038/s41587-023-02086-y

2.Xinrui Lin#; Yingwen Chen#; Li Lin#; Kun Yin; Rui Cheng; Xin Lin; Xiaoyu Wang; Ye Guo; Zhaorun Wu; Yingkun Zhang; Jin Li*; Chaoyong Yang*; Jia Song*; mitoSplitter: A mitochondrial variants-based method for efficient demultiplexing of pooled single-cell RNA-seq, Proceedings of the National Academy of Sciences of the United States of America, 2023, 120(39), e2307722120.

3.Xiaoxu Guo#; Fanghe Lin#; Chuanyou Yi; Juan Song; Di Sun; Li Lin; Zhixing Zhong; Zhaorun Wu; Xiaoyu Wang; Yingkun Zhang; Jin Li; Huimin Zhang*; Feng Liu*; Chaoyong Yang*; Jia Song* ; Deep transfer learning enables lesion tracing of circulating tumor cells, Nature Communications, 2022, 13: 7687.

4.Shichao Lin#; Kun Yin#; Yingkun Zhang#; Fanghe Lin#; Xiaoyong Chen; Xi Zeng; Xiaoxu Guo; Huimin Zhang; Jia Song*; chaoyong Yang*; Well-TEMP-seq as a microwell-based strategy for massively parallel profiling of single-cell temporal RNA dynamics, Nature Communications, 2023, 14:1272.

5.Li Lin#; Yufeng Zhang#; Weizhou Qian#; Yao Liu; Yingkun Zhang; Fanghe Lin; Cenxi Liu; Guangxing Lu; Di Sun; Xiaoxu Guo; YanLing Song; Jia Song*; Chaoyong Yang*; Jin Li*; LINEAGE: Label-free identification of endogenous informative single-cell mitochondrial RNA mutation for lineage analysis, Proceedings of the National Academy of Sciences of the United States of America，2022, 119(5): e2119767119.

6.Jia Song#; Yao Liu#; Xuebing Zhang; Qiuyue Wu; Juan Gao; Wei Wang; Jin Li*; Yanling Song*; Chaoyong Yang* ; Entropy Subspace Separation-based Clustering for Noise Reduction (ENCORE) of scRNA-seq Data, Nucleic Acids Research, 2021, 49(3): e18.

7.Xing Xu#; Li Lin#; Jian Yang#; Weizhou Qian#; Rui Su; Xiaoxu Guo; Linfeng Cai; Zirun Zhao; Jia Song*; Chaoyong Yang*; Simultaneous Single-Cell Genome and Transcriptome Sequencing in Nanoliter Droplet with Digital Microfluidics Identifying Essential Driving Genes, Nano Today, 2022, 46: 101596.

8.Kun Yin#; Meijuan Zhao#; Li Lin#; Yingwen Chen; Shanqing Huang; Chun Zhu; Xuan Liang; Fanghe Lin; Haopai Wei; Huimin Zeng; Zhi Zhu; Jia Song*; Chaoyong Yang*; Well‐Paired‐Seq: A Size‐ Exclusion and Locally Quasi‐Static Hydrodynamic Microwell Chip for Single‐Cell RNA‐Seq, Small Methods, 2022, 6: 2200341.

9.Ziyang Lu#; Fanghe Lin#; Tao Li#; Jinhui Wang; Cenxi Liu; Guangxing Lu; Bin Li; MingPei Pan; Shaohua Fan; Junqiu Yue; He Huang; Jia Song*; Chao Gu*; Jin Li*; Identification of clinical and molecular features of recurrent serous borderline ovarian tumour, eClinicalMedicine, 2022, 46: 101377.

10.Di Sun; Miao Sun; Jialu Zhang; Xin Lin; Yinkun Zhang; Fanghe Lin; Peng Zhang; Chaoyong Yang; Jia Song*; Computational tools for aptamer identification and optimization, Trends in Analytical Chemistry, 2022, 157: 116767 .

11.Yingkun Zhang; Xinrui Lin; Zhixian Yao; Di Sun; Xin Lin; Xiaoyu Wang; Chaoyong Yang; Jia Song*; Deconvolution algorithms for inference of the cell-type composition of the spatial transcriptome, Computational and Structural Biotechnology Journal, 2023, 21: 176-184.

12.Jia Song; Yuan Zheng; Mengjiao Huang; Lingling Wu; Wei Wang; Zhi Zhu; Yanling Song; Chaoyong Yang ; A Sequential Multidimensional Analysis Algorithm for Aptamer Identification based on Structure Analysis and Machine Learning, Analytical Chemistry, 2020, 92: 3307-3314.

13.Qianqian Zhang; Xing Xu; Li Lin; Jian Yang; Xing Na; Xin Chen; Lingling Wu; Jia Song*; Chaoyong Yang ; Cilo-seq: highly sensitive cell-in-library-out single-cell transcriptome sequencing with digital microfluidics, Lab on a Chip, 2022, 22: 1971-1979.

14.Liyuan Lin#; Jia Song#; Jian Li; Xiaolei Zuo; Hong Wei; Chaoyong Yang; Wei Wang ; Imaging the in vivo Growth Patterns of Bacteria in Human Gut Microbiota, Gut Microbes, 2021, 13(1): e1960134.

15.Xing Xu#; Qianqian Zhang#; Jia Song#; Qingyu Ruan#; Weidong Ruan; Yujie Chen; Jian Yang; Xuebing Zhang; Yanling Song; Zhi Zhu; Chaoyong Yang*. A Highly Sensitive, Accurate, and Automated Single-Cell RNA Sequencing Platform with Digital Microfluidics, Analytical Chemistry, 2020, 92: 8599-8606.

16.Xi Zeng#; Xiaoxu Guo#; Shaowei Jiang#; Xiaoping Yang; Zhixing Zhong; Siyu Liu; Zhi Zhu*; Jia Song*; Chaoyong Yang*; Digital-scRRBS: a cost-effective, highly sensitive and automated single-cell methylome analysis platform via digital microfluidics. Analytical Chemistry, 2023, 95, 13313−13321

17.Xi Zeng#; Shaowei Jiang#; Zhixing Zhong#;  Xiaoping Yang;  Qiuyue Chen;  Jin Li*;  Zhi Zhu*;  Jia Song*;  Chaoyong Yang*;  DIRECT: Digital Microfluidics for Isolation-Free Shared Library Construction of Single-Cell DNA Methylome and Transcriptome. Small Methods, 2023, 2301075.

Shichao Lin

86-13951896772; linscnano@163.com

Work Experience 

---

Aug 2022-Present Associate professor, Tan Kah Kee Innovation Laboratory, Xiamen University, Xiamen, China
Jul 2020-Jul 2022 Postdoctoral fellow, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China

Education 

---

Sep 2015-Jun 2020 Ph.D., College of Engineering and Applied Sciences, Nanjing University, Nanjing, China
Nov 2018-Jan 2019 Visiting Scholar, University of Massachusetts Amherst, USA
Sep 2011-Jun 2015 B.S., College of Engineering and Applied Sciences, Nanjing University, Nanjing, China

Honors and Awards

---

2019 Excellent Graduate Student of Nanjing University
2019 Talent Scholarship of Nanjing University
2019 Baxter China Young Investigator Awards
2019 NeoBioscience Scholarship
2016 Talent Scholarship of Nanjing University
2015 The First-class Academic Scholarship of Nanjing University

Publications 

---

1. Shichao Lin#, Huajie Ze#, Xia-Guang Zhang, Yue-Jiao Zhang, Juan Song, Huimin Zhang, Han-Liang Zhong, Zhi-Lan Yang, Chaoyong Yang, Jian-Feng Li, Zhi Zhu*. Direct and Simultaneous Identification of Multiple Mitochondrial Reactive Oxygen Species in Living Cells Using a SERS Borrowing Strategy. Angew. Chem. Int. Ed., 2022, 61, e202203511.

2. Xianzhi Zhang#, Shichao Lin#, Rui Huang, Aarohi Gupta, Stefano Fedeli, Roberto Cao-Milán, David C. Luther, Yuanchang Liu, Mingdi Jiang, Gengtan Li, Brayan Rondon, Hui Wei, Vincent M. Rotello*. Degradable ZnS-Supported Bioorthogonal Nanozymes with Enhanced Catalytic Activity for Intracellular Activation of Therapeutics. J. Am. Chem. Soc., 2022, 144, 28, 12893-12900.

3. ​​​​​​Shichao Lin#, Yilong Liu#, Mingxia Zhang, Xing Xu, Yingwen Chen, Huimin Zhang*, Chaoyong Yang*. Microfluidic single-cell transcriptomics: moving towards multimodal and spatiotemporal omics. Lab on a Chip, 2021, 21, 3829-3849.

4. Shichao Lin#, Yuan Cheng#, He Zhang#, Xiaoyu Wang, Yuye Zhang, Yuanjian Zhang, Leiying Miao, Xiaozhi Zhao, Hui Wei*. Copper tannic acid coordination nanosheet: a potent nanozyme for scavenging ROS from cigarette smoke. Small, 2019, 201902123.

5. Shichao Lin, Hui Wei*. Design of high performance nanozymes: a single-atom strategy. Sci. China Life Sci., 2019, 62, 710-712.

6. Shichao Lin, Yihong Zhang, Wen Cao, Xiaoyu Wang, Li Qin, Min Zhou, Hui Wei*. Nucleobase-mediated synthesis of nitrogen-doped carbon nanozymes as efficient peroxidase mimics. Dalton Trans., 2019, 48, 1993-1999.

7. Shichao Lin#, Hanjun Cheng#, Qiran Ouyang, Hui Wei*. Deciphering the quenching mechanism of 2D MnO2 nanosheet towards Au nanocluster fluorescence to design effective glutathione biosensor. Anal. Methods, 2016, 8, 3935-3940.

Juan Gao

Gao Juan