Department of Chemical Biology
Yang's Lab,Department of Chemical Biology, Xiamen University
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Professor Yang

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Yang's Laboratory

Room 532, Lujiaxi Building, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China

Ph: +86 (0) 592-218 7601

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Investigator

  • Chaoyong James Yang



    Professor, Principal Investigator


    Education:

    Dept. Chem., Xiamen Univ., Sept. 1994 - Jul. 1998 B.S.

    Dept. Chem., Xiamen Univ., Sept. 1998 - Jul. 2001, M.S.

    Department of Chemistry, University of Florida, USA. Aug.2001-Aug. 2006, Ph.D,

     

    Professional Experience:

    Postdoctoral Fellow, Department of Chemistry, University of California, Berkeley, 2006.9-2007.12, Advisor: Professor Richard Mathies.

    Professor, Department of Chemical Biology, Xiamen University, 2008.1-

    Advisory Board Member, Analyst, 2013.03

    Associate Editor, BMC Biochemistry, 2013.07-

    Editorial Advisory Board Member, Biomicrofluidics, 2015.01
     

     

    Phone: +86 (0) 592-218 7601
    E-mail: cyyang@xmu.edu.cn

     

    Address:

    Room 532, Lujiaxi Building, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China

     

    Honors and Awards:

     Fellow of the Royal Society of Chemistry (2014)

    Distinguished Young Investigator Award, National Science Foundation of China (2013)

    Yunsheng Youth Scientific & Technical Award, Fujian Province (2013)

    Distinguished Faculty Award,Chinese-American Chemistry & Chemical Biology Professors Association (2012)

    Youth Medal, Fujian Province (2012)

    Chinese Government Award for Outstanding Students Abroad (2006)

    Sigma Xi Graduate Research Award, University of Florida (2006)

    O’Neil Dissertation Fellowship, University of Florida (2005-2006)

    American Chemical Society, DAC Graduate Fellowship (2005, Merck&Co.)

     

    Major Research Grants:

    2008-2010, Natural Science Foundation of Fujian Province (2008J0107), PI, Aptamers for Cancer Stem Cell Study

    2009-2011, Research Fund for New Faculty of the Doctoral Program of Higher Education of China, PI, Microfluidics for Single Cell Gene Expression Study

    2009-2011, Natural Science Foundation of China (20805038), PI, Molecular Tools for Living Cell mRNA Imaging

    2010-2014, National Basic Research Program of China (973 Program, 2010CB732402), co-PI, Molecular Recognition Tools for Cancer Diagnosis

    2011-2013, Natural Science Foundation of China (21075104), PI, Droplet Microfluidics for Single Cell Study

    2011-2015, Ministry of Science and Technology (2011YQ3012412), co-PI, PERS for Cancer Imaging

    2013-2016, Natural Science Foundation of China (21275122), PI, Aptamer Functionalized Microfluidic Devices for Circulating Tumor Cell Enrichment and Detection

    2014-2015, Key Research Plan of Natural Science Foundation of China (91313302), co-PI, Small Molecular Probes for the Study of Signal Tranduction Pathways.

    2014-2017, Distinguished Young Investigator Award (National Science Foundation of China) , PI, Bioanalytical Chemistry
     

    Current Research:

    Microfluidics, Molecular Recognitions, DNA Self-assembly, Early Diagnosis of Cancer,


    1) We are establishing new microfluidic methods for high throughput single cell gene expression study and single cell protein counting, which will enable us to efficiently compare gene expression at both mRNA and protein level with single cell resolution from a large population of cells.


    2) We are developing new molecular recognition ligands to recognize target proteins from single cells and cancer cells from a large population of normal cells with high selectivity. These ligands will be used for protein/cell imaging or protein/cell capture probes in single cell analysis.


    3) DNA’s remarkable molecular recognition properties and structural features make it one of the most promising templates to pattern materials with nanoscale precision. We are exploring the feasibility of using the potent recognition capability of aptamers to construct DNA superstructures and explore their possible applications to disease diagnosis and therapy.

     

    Integrating our microfluidic techniques, molecular recognition ligands and DNA nanostructures, we hope to develop new methods to address challenging problems of cancer diagnosis.

  • Zhi Zhu

    86-18750268060; zhuzhi8420@gmail.com; zhuzhi@xmu.edu.cn

    Working Experience______________________________________________________________
    • Aug 2015-present       Professor, Department of Chemical Biology, College of Chemistry and Chemical Engineering,  Xiamen University, Xiamen, China
    • Jan 2012-present       Associate Professor, Department of Chemical Biology,College of Chemistry and
    Chemical Engineering, Xiamen University, Xiamen, China
    • Aug 2011-Jan 2012    Assistant Professor,  Department of Chemical Biology, College of Chemistry and
    Chemical Engineering, Xiamen University, Xiamen, China
    EDUCATION____________________________________________________________________                                                        
    • University of Florida, Ph.D. in Analytical Chemistry,May 2011    Gainesville, FL   
    Research Advisor: Dr. Weihong Tan
    • Peking University,  B. S. Chemistry, 2006Beijing, China                           
    Research Advisor: Dr. Chunhua Yan
    RESEARCH EXPERIENCE________________________________________________________
    2012-Present Associate Professor, Xiamen University                                                                          Xiamen, China
    2011-2012Assistant Professor, Xiamen University         Xiamen, China
    • DNA self-assembly and molecular engineering for cancer diagnosis
    • Microfluidics for single molecule and single cell analysis
    2007 – 2011Research Assistant, University of FloridaGainesville, FL 
    (Supervisor: Dr. Weihong Tan)
    • Functional-DNA cross-linked, target-responsive hydrogel for sensitive visual detection
    • Molecular mediation of photodynamic therapyusing carbonnanomaterials
    2006 – 2007 Teaching Assistant, University of Florida   Gainesville, FL
    (Supervisor: Dr. James C. Horvath)
    • Teaching assistant for general chemistry lab II
    2004 – 2006Undergraduate Research Assistant, Peking University            Beijing, China
    (Supervisor: Dr. Chunhua Yan)
    • Synthesis and properties of tetrathiafulvalene derivative pending a fluorophore
    HONORS AND AWARDS__________________________________________________________
    • 2010    Chinese Government Award for Outstanding Students Aboard
    • 2009    ACS Division of Analytical Chemistry Nine-Month Graduate Fellowship
    • 2009   Roger G. Bates and Herbert A. Laitinen Fellowships, University of Florida
    • 2008   Crow and Stasch Awards for excellence in scientific publication, University of Florida
    • 2008 Honorary Mention for Poster Presentation at the 1st Annual Nanoscience Technology Symposium held at
    University of Central Florida
    • 2007   Graduate Achievement Award, University of Florida
    • 2006-present    Alumni Fellowship, University of Florida
    • 2005    Xianglu Fellowship (for outstanding achievement, versatile personality and excellent studentwork),
    Peking University
    • 2004    Model of Outstanding Students, Peking University
    • 2003    Second-class national Scholarship, Peking University
    Xiyue Fellowship, Peking University
    • 2002    First-class National Scholarship (for freshmen with excellent records in the entrance examination to
    colleges and universities), Peking University
    PUBLICATIONS_________________________________________________________________
    • Ling Yan, Zhi Zhu, Yuan Zou, Yishun Huang, Dewen Liu, ShashaJia, DunmingXu, Min Wu, Yu Zhou, Shuang Zhou, Chaoyong James Yang. “Target-responsive ‘Sweet’ Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-glucose Targets.” Journal of the American Chemical Society,2013,DOI: 10.1021/ja3114714. (Co-first authors)
    • Da Han,Zhi Zhu, Cuichen Wu, Lu Peng, Leiji Zhou, BasriGulbakan, Guizhi Zhu, Kathryn R. Williams, and Weihong Tan. “A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer–Protein Interactions.”Journal of the American Chemical Society,2012,134,20797-20804.(Co-first authors)
    • Ling Zhu, Cong Li, Zhi Zhu, Dewen Liu, Yuan Zou, ChunmingWang, Hao Fu, Chaoyong James Yang. “In Vitro Selection of Highly Efficient G-Quadruplex-Based DNAzymes.”Analytical Chemistry, 2012,84, 8383-8390. (co-first authors)
    • Jie Wu, Chi Wang, Xilan Li, Yanling Song, Wei Wang, Cong Li, Jia Hu, Zhi Zhu*, Jiuxing Li, Weiyun Zhang, Zhongxian Lu*, Chaoyong James Yang*. “Identification, Characterization and Application of a G-Quadruplex Structured DNA Aptamer against Cancer Biomarker Protein Anterior Gradient Homolog 2.”Plos One, 2012, 7, e46393.
    • Cong Li, Ling Zhu, Zhi Zhu, Hao Fu, Gareth Jenkins, Chunming Wang, Yuan Zou, Xin Lu, Chaoyong James Yang. “Backbone Modification Promotes Peroxidase Activity of G-Quadruplex-Based DNAzyme.”Chem. Commun.,2012, 48,8347-8349. (co-first authors)
    • Zhi Zhu, Wenhua Zhang, XuefeiLeng, Mingxia Zhang, Zhichao Guan and Chaoyong James Yang. “Highly Sensitive and Quantitative Detection of Rare Pathogens through Agarose Droplet Microfluidic Emulsion PCR at the Single-Cell Level.”Lab Chip, 2012, 12, 3907-3913.
    • ZhiZhu, Gareth Jenkins, WenhuaZhang,Mingxia Zhang,ZhichaoGuan, Chaoyong James Yang. “Single-Molecule Emulsion PCR in Microfluidic Droplet.” Analytical Bioanalytical Chemistry, 2012,403, 2127-2143.
    • Yanling Song, Weiting Zhang, Yuan An, Liang Cui, Chundong Yu,Zhi Zhu*, Chaoyong James Yang*. “Label-free visual detection of nucleic acids in biological samples with single-base mismatch detection capability.”Chem. Commun.,2012, 48, 576–578.
    • Ying Pu, Zhi Zhu, Da Han, Huixia Liu, Jun Liu, Jie Liao, Kejing Zhang, Weihong Tan. “Insulin-Binding Aptamer-Conjugated Graphene Oxide for Insulin Detection.”Analyst, 2011,47, 4138-4140. (co-first authors)
    • Chungming Wang, Zhi Zhu, Yanling Song, Hui Lin, Chaoyong James Yang, Weihong Tan. “Caged Molecular Beacons: Controlling Nucleic Acid Hybridization with Light.”Chem. Commun.,2011, 47, 5708-5710. (co-first authors)
    • Zhi Zhu, Cuichen Wu, Haipeng Liu, Yuan Zou, Xiaoling Zhang, Huaizhi Kang, Chaoyong James Yang, Weihong Tan. “An Aptamer Cross-linked Hydrogel as a Colorimetric Platform for Visual Detection.” Angew. Chem. Int. Ed., 2010, 49, 1052-1056.
    • Zhi Zhu, Ronghua Yang, Mingxu You, Xiaoling Zhang, Yanrong Wu, Weihong Tan. “Single-walled Carbon Nanotube as an Effective Quencher.” Analytical Bioanalytical Chemistry, 2010,396, 73-83.
    • Zhi Zhu, Zhiwen Tang, Joseph A. Phillips, Ronghua Yang, Hui Wang, Weihong Tan. “Regulation of Singlet Oxygen Generation Using Single-Walled Carbon Nanotubes.”Journal of the American Chemical Society,2008, 130, 10856-10857.
    • Tao Chen, CuichenSam Wu, Elizabeth Jimenez, Zhi Zhu, Joshua G. Dajac, Mingxu You, Da Han, Xiaobing Zhang and Weihong Tan. “DNA Micelle Flares for Intracellular mRNA Imaging and Gene Therapy.”Angew. Chem. Int. Ed.,2013, DOI: 10.1002/anie.201209440.
    • GuoliangKe, Chunming Wang, Yun Ge, NanfengZheng, Zhi Zhu,Chaoyong James Yang. “L-DNA Molecular Beacon: A Safe, Stable, and Accurate Intracellular Nano-thermometer for Temperature Sensing in Living Cells.”Journal of the American Chemical Society,2012,134, 18908-18911.
    • Xiaohong Tan, Tao Chen, Xiangling Xiong, Ye Mao, Guizhi Zhu, Emir Yasun, Chunmei Li, Zhi Zhu, Weihong Tan. “Semiquantification of ATP in Live Cells Using Nonspecific Desorption of DNA from Graphene Oxide as the Internal Reference.”Analytical Chemistry, 2012,84, 8622-8627.
    • Xiaohong Tan, Weijun Chen, Shun Lu, Zhi Zhu, Tao Chen, Guizhi Zhu, Mingxu You, Weihong Tan. “Molecular Beacon Aptamers for Direct and Universal Quantitation of Recombinant Proteins from Cell Lysates.”Analytical Chemistry, 2012,84, 8272-8276.
    • Dezhi Kang, Jiangjie Wang, Weiyun Zhang, Yanling Song, Xilan Li, Yuan Zou, Mingtao Zhu,Zhi Zhu, Fuyong Chen, Chaoyong James Yang. “Selection of DNA Aptamers against Glioblastoma Cells with High Affinity and Specificity.”Plos One, 2012, 7, e42731.
    • Xue-Qin Zhao, Jie Wu, Jing-Hong Liang, Jia-Wei Yan, Zhi Zhu, Chaoyong James Yang, Bing-Wei Mao. “Single-Molecule Force Spectroscopic Studies on Intra- and Intermolecular Interactions of G-Quadruplex Aptamer with Target Shp2 Protein.”Journal of Physical ChemistryB, 2012, 116, 11397-11404.
    • Liang Cui, Yuan Zou, Ninghang Lin, Zhi Zhu, Gareth Jenkins, Chaoyong James Yang. “Mass Amplifying Probe for Sensitive Fluorescence Anisotropy Detection of Small Molecules in Complex Biological Samples.”Analytical Chemistry, 2012,84, 5535-5541.
    • HuifaZhang, Gareth Jenkins, Yuan Zou,ZhiZhu, Chaoyong James Yang. “Massively Parallel Single-Molecule and Single-Cell Emulsion Reverse Transcription Polymerase Chain Reaction Using Agarose Droplet Microfluidics.”Analytical Chemistry, 2012,84, 3599-3606.
    • Lu Peng, Zhi Zhu, Yan Chen, Da Han, Weihong Tan. “An Exonuclease III and GrapheneOxide-Aided Assay for DNA Detection.”Biosensors Bioelectronics, 2012,35, 475-478.
    • Mohammed I.Shukoor,  Meghan O.Altman, Da Han,Abdullah TahirBayrac, Ismail Ocsoy,ZhiZhu, WeihongTan. “Aptamer-Nanoparticle Assembly for Logic-Based Detection.”ACS Applied Materials & Interfaces, 2012,4, 3007-3011.
    • Jian Wang, Guizhi Zhu, Mingxu You, Erqun Song, Mohammed I.Shukoor, Kejing Zhang, Meghan O.Altman, Yan Chen, Zhi Zhu, Cheng Zhi Huang, Weihong Tan. “Assembly of Aptamer Switch Probes and Photosensitizer on Gold Nanorods for Targeted Photothermal and Photodynamic Cancer Therapy.”ACS Nano, 2012, 6, 5070-5077.
    • Bin-Cheng Yin, Bang-Ce Ye, Hui Wang, Zhi Zhu, Weihong Tan. “Colorimetric logic gates based on aptamer-crosslinked hydrogels.”Chem. Commun.,2012, 48, 1248–1250.
    • Weiyun Zhang, Wenhua Zhang, Zhiyuan Liu, Cong Li, Zhi Zhu, Chaoyong Yang. “Highly Parallel Single-Molecule Amplification Approach Based on Agarose Droplet Polymerase Chain Reaction for Efficient and Cost-Effective Aptamer Selection.”Analytical Chemistry,2012, 84, 350-355.
    • Liang Cui, Xiaoyan Lin, Ninghang Lin, Yanling Song,Zhi Zhu, Xi Chen, Chaoyong James Yang. “Graphene oxide-protected DNA probes for multiplex microRNA analysis in complex biological samples based on a cyclic enzymatic amplification method.”Chem.Commun.,2012, 48, 194-196.
    • Jun Liu, Huixia Liu, Huaizhi Kang, Michael Donovan, Zhi Zhu, Weihong Tan. “Aptamer-incorporated hydrogels for visual detection, controlled drug release, and targeted cancer therapy.”Analytical Bioanalytical Chemistry, 2012,402, 187-194.
    • Kelong Wang, Mingxu You, Yan Chen, Da Han, Zhi Zhu, Jin Huang, Kathryn William, Chaoyong James Yang, Weihong Tan. “Self-assembly of aBifunctionalDNA Carrier for Drug Delivery.”Angew. Chem. Int. Ed.,2011, 50,6098-6101.
    • Da Han, Jin Huang, Zhi Zhu, Quan Yuan, Mingxu You, Yan Chen and Weihong Tan. “Molecular Engineering of Photoresponsive Three-dimensional DNA Nanostructures.” Chem. Commun.,2011,47, 4670-4672.
    • Jin Huang, Yan Chen, Liu Yang,Zhi Zhu, Guizhi Zhu, Xiaohai Yang, Kemin Wang, Weihong Tan. “Amplified detection of cocaine based on strand-displacement polymerizationand fluorescence resonance energy transfer.”Biosensors Bioelectronics, 2011,28, 450-453.
    • Zhuo Chen, Xiaobing Zhang, Ronghua Yang, Zhi Zhu, Yan Chen and Weihong Tan. “Single-walled Carbon Nanotubes as Optical Materials for Biosensing.” Nanoscale,2011,3, 1949-1956.
    • Jin Huang, Yanrong Wu, Yan Chen, Zhi Zhu, Xiaohai Yang, Chaoyong James Yang, Kemin Wang and Weihong Tan. “Pyrene-Excimer Probes Based on the Hybridization Chain Reaction for the Detection of Nucleic Acids in Complex Biological Fluids.” Angew. Chem. Int. Ed.,2011, 50, 401-404.
    • Huaizhi Kang, Haipeng Liu, Xiaoling Zhang, Jilin Yan, Zhi Zhu, Lu Peng, Huanghao Yang, Youngmi Kim, Weihong Tan. “Photoresponsive DNA-Cross-Linked Hydrogels for Controllable Release and Cancer Therapy.”Langmuir, 2011,27, 399-408.
    • Yamin Li, Xiaoling Zhang, Baocun Zhu, Juan Xue, Zhi Zhu, Weihong Tan. “A Simple but Highly Sensitive and Selective Colorimetric and Fluorescent Probe for Cu2+ in Aqueous Media.” Analyst, 2011,136, 1124-1128.
    • Tao Chen, Mohammed Ibrahim Shukoor, Yan Chen, Quan Yuan, Zhi Zhu,Zilong Zhao, BasriGulbakan, Weihong Tan. “Aptamer-conjugated Nanomaterials for Bioanalysis and Biotechnology Applications.” Nanoscale, 2011, 3, 546-556.
    • Ying Pu, Zhi Zhu, Huixia Liu, Jiani Zhang, Jun Liu, Weihong Tan. “Using Aptamers to Visualize and Capture Cancer Cells.” Analytical Bioanalytical Chemistry,2010, 397, 3225-3233.
    • Jin Huang, Zhi Zhu, SuwussaBamrungsap, Guizhi Zhu, Mingxu You, Xiaoxiao He, Kemin Wang, Weihong Tan. “Competition-Mediated Pyrene-Switching Aptasensor: Probing Lysozyme in Human Serum with a Monomer-Excimer Fluorescence Switch.”Analytical Chemistry, 2010,82, 10158-10163.
    • Basri Gulbakan, Emir Yasun, M. Ibrahim Shukoor, Zhi Zhu, Mingxu You, Xiaohong Tan, Hernan Sanchez, David H. Powell, Hongjie Dai, Weihong Tan.“A Dual Platform for Selective Analyte Enrichment and Ionization in Mass Spectrometry Using Aptamer-Conjugated Graphene Oxide.”Journal of the American Chemical Society, 2010,132, 17408-17410.
    • Mingxu You, Zhi Zhu,Haipeng Liu, BasriGulbakan, Da Han, Ruoren Wang, Kathryn R. Williams, Weihong Tan. “Pyrene-Assisted Efficient Photolysis of Disulfide Bonds in DNA-Based Molecular Engineering.”ACS Applied Materials & Interfaces, 2010,2, 3601-3605.
    • Haipeng Liu, Zhi Zhu, Huaizhi Kang, Yanrong Wu, Kwame Sefan, Weihong Tan.“DNA-Based Micelles: Synthesis, Micellar Properties and Size-Dependent Cell Permeability.”Chemistry--A European Journal,2010, 16, 3791-3797,
    • Zhiwen Tang, Zhi Zhu, PrabodhikaMallikaratchy, Ronghua Yang, Kwame Sefah, Weihong Tan. “Aptamer-Target Binding Triggered Molecular Mediation of Singlet Oxygen Generation.”Chemistry--An Asian Journal,2010, 5, 783-786.
    • Yan Liu; Se Won Bae, Kelong Wang, Jong-In Hong, Zhi Zhu, Weihong Tan, Dimitri Pappas. “The Effects of Flow Type on Aptamer Capture in Differential Mobility Cytometry Cell Separations.” AnalyticaChimicaActa,2010, 673, 95-100.
    • Xiaolan Chen, M.-Carmen Estevez, Zhi Zhu, Yu-fen Huang, Yan Chen, Lin Wang, Weihong Tan. “Using Aptamer-Conjugated Fluorescence Resonance Energy Transfer Nanoparticles for Multiplexed Cancer Cell Monitoring.”Analytical Chemistry, 2009, 81,7009-7014.
    • Hui Wang, Youngmi Kim, Haipeng Liu, Zhi Zhu, Suwussa Bamrungsap, Weihong Tan.  “Engineering a Unimolecular DNA-Catalytic Probe for Single Lead Ion Monitoring.”Journal of the American Chemical Society,2009,131, 8221-8226.
    • Yan Chen, Alina C. Munteanu, Yu-Fen Huang, Joseph Phillips,Zhi Zhu, Michael Mavros, Weihong Tan. “Mapping Receptor Density on Live Cells Using Fluorescence Correlation Spectroscopy.”Chemistry-A European Journal, 2009, 15, 5327-5336.
    • Zhiwen Tang,PrabodhikaMallikaratchy, Ronghua Yang,Youngmi Kim, Zhi Zhu,Hui Wang,Weihong Tan. “Aptamer Switch Probe Based on Intramolecular Displacement.”Journal of the American Chemical Society,2008,130, 11268-11269.
    • Ronghua Yang, Jianyu Jin, Yan Chen, Na Shao, Huaizhi Kang, Zeyu Xiao, Zhiwen Tang, Yanrong Wu, Zhi Zhu, Weihong Tan.“Carbon Nanotube-Quenched Fluorescent Oligonucleotides: Probes that Fluoresce upon Hybridization.”Journal of the American Chemical Society, 2008,130, 8351-8358.
    • Joseph A. Phillips, Dalia Colon-Lopez, Zhi Zhu, Ye Xu, Weihong Tan. “Applications of Aptamers in Cancer Cell Biology.” AnalyticaChimicaActa, 2008,621, 101-108.
    • Ronghua Yang,Zhiwen Tang,Jilin Yan, Huaizhi Kang,Youngmi Kim,Zhi Zhu,Weihong Tan.   “Noncovalent Assembly of Carbon Nanotubes and Single-Stranded DNA: An Effective Sensing Platform for Probing Biomolecular Interactions.” Analytical Chemistry,2008, 80, 7408-7413.
    • Wei Sun, Chun-Hu Xu, Zhi Zhu, Chen-Jie Fang, and Chun-Hua Yan.“Chemical-Driven Reconfigurable Arithmetic Functionalities within a Fluorescent Tetrathiafulvalene Derivative.” Journal of Physical Chemistry C, 2008,112, 16973-16983.
    • Chen-Jie Fang, Zhi Zhu, Wei Sun, Chun-Hu Xu, Chun-Hua Yan. “New TTF derivatives: Several molecular logic gates based on their switchable fluorescent emissions.”New Journal of Chemistry, 2007, 31, 580-586.
    PRESENTATIONS_______________________________________________________________
    • Zhi Zhu. “Portable and Quantitative Detection Platform Based on Functional DNA Crosslinked Hydrogel.”5thInternational Symposium on Biomedical Engineering, Bioanalysis and Nanotechnology, Changsha, China, June, 2012
    • Zhi Zhu. “Carbon Nanomaterials as Effective Quenchers for Biosensing and Targeted Therapy.”3rd Asian Spectroscopy Conference, Xiamen, China, November 2011
    • Zhi Zhu, Jin Huang, Xiangling Xiong, Weihong Tan. “mRNA/Graphene oxide for molecular mediation of photodynamic therapy. ” 241st ACS National Meeting & Exposition, Anaheim, CA, March 2011
    • Zhi Zhu, Mohammed Ibrahim Shukoor, Weihong Tan. “Logic Switchboard for Medical Diagnosis.”62ndPittsburgh Conference, Atlanta, GA, March 2011
    • Zhi Zhu, Haipeng Liu, Chaoyong James Yang, Weihong Tan.“Functional DNA cross-linked hydrogel for visual detection.”Gordon Research Conference 2010, Bioanalytical Sensors, New London, NH, June 2010
    • Zhi Zhu, Weihong Tan. “Aptamer-switches for Bioanalytical and Biomedical Applications.” Invited Seminar, Proctor & Gamble, Cincinnati, OH, March2010
    • Zhi Zhu, Haipeng Liu, Chaoyong Yang, Weihong Tan. “Aptamer cross-linked Hydrogel for Visual Detection.” 61stPittsburgh Conference, Orlando, FL, March2010
    • Zhi Zhu, Weihong Tan. “Target-responsive Aptamer-switches for Bioanalytical and Biomedical Applications.” Invited Seminar, Xiamen University, China, April 2009
    • Zhi Zhu, Haipeng Liu, Joseph Phillips, Weihong Tan. “Aptamer-crosslinked Target-responsive Hydrogel for Sensitive Visual Detection.” 60th Pittsburgh Conference, Chicago, IL, March 2009
    • Zhi Zhu,Zhiwen Tang, Weihong Tan. “Regulation of Singlet Oxygen Generation Using Aptamers and Single-walled Carbon Nanotubes.”1st Annual Nanoscience Technology Symposium, Orlando, FL, September 2008
    • Zhi Zhu,Hui William Chen, Weihong Tan. “Aptamer Conjugated Nanoparticles for Cancer Biomarker Studies.” 59th Pittsburgh Conference, New Orleans, LA, March 2008
    • Chen-jie Fang, Zhi Zhu, Chun-hua Yan. “Synthesis and Crystal Structure of Novel Cadmium(II) Complexes” 05-P-201, 5th Chinese NationalCoordination Chemistry Conference, Guangzhou, China, November2005

  • Leiji Zhou

    86-18750268060; ljzhou@xmu.edu.cn
    Working Experience______________________________________________________________

    • Aug 2005-present       Associate Professor, Department of Chemistry, Xiamen University
    • Mar 2003-Mar 2005    Postdoctoral Fellow,  College of Material Sciences and Engineering, Hunan Univ.

    EDUCATION____________________________________________________________________                                                        
    • Dept. Chem., Hunan Univ., Sept. 1998 - Jul. 2002, Ph.D,
       Advisor: Professor Kemin Wang.
    • Dept. Chem., Hunan Univ., Sept. 1995 - Jul. 1998, M.S.
      Advisor: Professor Kemin Wang.
    • Dept. Chem., Hunan Univ., Sept. 1989 - Jul. 1993 B.S.


    RESEARCH EXPERIENCE________________________________________________________
    2007-2010, National Natural Science Foundation of China (No. 20775065), PI

    2007-2010, Specialized Research Fund for the Doctoral Program of Higher Education (No. 20070384023), PI

    2008-2010, Specialized Fund for Agro-scientific Research in the Public Interest (200803033), PI
     
    Current Research:
    Chemo/bio-sensing and Biochips; Bio-analytical chemistry.

    HONORS AND AWARDS__________________________________________________________
    • 2003  The first prize for Progress in science and Technology in Hunan province

    PUBLICATIONS_________________________________________________________________
    • 1.      Xiao, Xifeng; Jiang, Xiaoqun, Zhou, Leiji. Surface Modification of Poly Ethylene Glycol to Resist Nonspecific Adsorption of Proteins, Chinese J of Anal Chem. 2013, 41 (3), 445-453.
      2.      Han, Da; Zhu, Zhi; Wu, Cuichen; Peng, Lu; Zhou, Leiji; Gulbakan, Basri; Zhu, Guizhi; Williams, Kathryn R.; Tan, Weihong. A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer-Protein Interactions, Journal of the American Chemical Society, 2012, 134, 20797-20804.
      3.      Zhou, Leiji; Wang, Kemin; Tan, Weihong; Chen, Yunqing; Zuo, Xinbing; Wen, Jianhui; Liu, Bin; Tang, Hongxing; He, Lifang; Yang, Xiaohai. Quantitative Intracellular Molecular Profiling Using a One-Dimensional Flow System, Analytical Chemistry, 2006, 78, 6246-6251.
      4.      Zhou, Leiji; Wang, Kemin; Choi, Martin M. F.; Xiao, Dan; Yang, Xiaohai; Chen, Rui; Tan, Weihong. Fiber-Optic Mode-Filtered Light Sensor for General and Rapid Chemical Assay, Measurement Science and Technology, 2004, 15, 137-142.
      5.      Zhou, Leiji; Wang, Kemin; Zuo, Xinbing; Choi, Martin M. F.; Chen, Yunqing; Huang, Shasheng. Mixed C18 and C1 Modification on an Optical Fiber for Chromatographic Sensing, Electrophoresis, 2003, 24, 3207-3211.
      6.      Zhang, He; Yang, Xiaohai; Wang, Kemin; Tan, Weihong; Zhou, Leiji; Zuo, Xinbing; Wen, Jianhui; Chen, Yunqing. Detection of Single-Base Mutations Using 1-D Microfluidic Beads Array, Electrophoresis, 2007, 28, 4668-4678.
      7.      Wen, Jianhui; Yang, Xiaohai; Wang, Kemin; Tan, Weihong; Zhou, Leiji; Zuo, Xinbing; Zhang, He; Chen, Yunqing. One-dimensional microfluidic beads array for multiple mRNAs expression detection, Biosensors and Bioelectronics, 2007, 22, 2759-2762.
      8.      Zuo, Xinbing; Yang, Xiaohai; Wang, Kemin; Tan, Weihong; Li, Huimin; Zhou, Leiji; Wen, Jianhui; Zhang, He. Improving the Performance of Immobilized Molecular Beacons through Cleavage, Analytica Chimica Acta, 2006, 567, 173-178.

  • Shaohuang Weng

    Shaohuang Weng