31. Xiyuan Yu#, Weidong Ruan#, Fanghe Lin, Weizhou Qian, Yuan Zou, Yilong Liu, Rui Su, Qi Niu, Qingyu Ruan, Wei Lin, Zhi Zhu, Huimin Zhang*, Chaoyong Yang*. Digital microfluidics-based digital counting of single-cell copy number variation (dd-scCNV Seq). Proc. Natl. Acad. Sci. U.S.A., 2023, 120, e2221934120. 

30. Shichao Lin#, Kun Yin#, Yingkun Zhang#, Fanghe Lin#, Xiaoyong Chen, Xi Zeng, Xiaoxu Guo, Huimin Zhang, Jia Song*, Chaoyong Yang*. Well-TEMP-seq as a microwell-based strategy for massively parallel profiling of temporal dynamics in single-cells. Nat. Commun., 2023, 14, 1272. 

29. Xiyuan Yu, Wei Lin, Qian Lai, Juan Song, Yilong Liu, Rui Su, Qi Niu, Liu Yang, Chaoyong Yang, Huimin Zhang*, Zhi Zhu*. ARMOR: Auto-Assembled Resilient Biomimetic Calcified Ornaments for Selective Cell Protection by Dual-Aptamer-Driven Hybridization Chain Reaction. Angew. Chem. Int. Ed., 2023, 62, e202301083.

28. Yuqi Wu, Bingqian Lin, Yinzhu Lu, Liang Li, Kunyue Deng, Suhui Zhang, Huiming Zhang, Chaoyong Yang, Zhi Zhu*. Aptamer-LYTACs for Targeted Degradation of Extracellular and Membrane Proteins. Angew. Chem. Int. Ed., 2023, 62, e202218106.

27. Dongxia Chen#, Junnan Guo#, Ao Li, Chengjie Sun, Huibin Lin, Hongyu Lin, Chaoyong Yang*, Wei Wang*, Jinhao Gao*. Metabolic Fluorine Labeling and Hotspot Imaging of Dynamic Gut Microbiota in Mice. Sci. Adv., 2023, 9, eabg6808. 

26. Xiaoxu Guo#, Fanghe Lin#, Chuanyou Yi, Juan Song, Di Sun, Li Lin, Zhixing Zhong, Zhaorun Wu, Xiaoyu Wang, Yingkun Zhang, Jin Li, Huimin Zhang*, Feng Liu*, Chaoyong Yang*, Jia Song*. Deep transfer learning enables lesion tracing of circulating tumor cells. Nat. Commun., 2022, 13, 7687. 

25. Jialu Zhang#, Yunyun Xu#, Mingying Chen, Yihao Huang, Ting Song, Chaoyong Yang, Yang Yang*, Yanling Song*. Elucidating the Effect of Nanoscale Receptor-Binding Domain Organization on SARS-CoV-2 Infection and Immunity Activation with DNA Origami. J. Am. Chem. Soc., 2022, 144, 21295–21303.

24. Junxia Wang#, Liang Li#, Yingkun Zhang, Kaifeng Zhao, Xiaofeng Chen, Haicong Shen, Yuanqiang Chen, Jia Song, Yuqiang Ma, Chaoyong Yang, Hongming Ding*, Zhi Zhu*. Synergetic Collision and Space Separation in Microfluidic Chip for Efficient Affinity-Discriminated Molecular Selection. Proc. Natl. Acad. Sci. U.S.A., 2022, 119, e2211538119. 

23. Shichao Lin^#, Huajie Ze^#, Xia-Guang Zhang, Yue-Jiao Zhang, Juan Song, Huimin Zhang, Han-Liang Zhong, Zhi-Lan Yang, Chaoyong Yang, Jian-Feng Li, and Zhi Zhu*. Direct and Simultaneous Identification of Multiple Mitochondrial Reactive Oxygen Species in Living Cells Using a SERS Borrowing Strategy. Angew. Chem. Int. Ed., 2022, 61, e2022035.

22. Li Lin^#, Yufeng Zhang^#, Weizhou Qian^#, Yao Liu, Yingkun Zhang, Fanghe Lin, Cenxi Liu, Guangxing Lu, Di Sun, Xiaoxu Guo, YanLing Song, Jia Song*, Chaoyong Yang*, and Jin Li*. LINEAGE: Label-free identification of endogenous informative single-cell mitochondrial RNA mutation for lineage analysis. PNAS, 2022, 119, e2119767119.

21. Miao Sun^#, Siwen Liu^#, Ting Song, Fude Chen, Jialu Zhang, Jia-ao Huang, Shuang Wan, Yao Lu, Honglin Chen*, Weihong Tan*, Yanling Song*, Chaoyong Yang*. Spherical Neutralizing Aptamer Inhibits SARS-CoV-2 Infection and Suppresses Mutational Escape. J. Am. Chem. Soc., 2021, 143, 21541–21548.

20. Miao Sun, Siwen Liu, Xinyu Wei, Shuang Wan, Mengjiao Huang, Ting Song, Yao Lu, Xiaonan Weng, Zhu Lin, Honglin Chen*, Yanling Song*, and Chaoyong Yang*. Aptamer Blocking Strategy Inhibits SARS-CoV-2 Virus Infection. Angew. Chem. Int. Ed., 2021, 60, 10266–10272.

19. Bingqian Lin, Tian Tian, Yinzhu Lu, Dan Liu, Mengjiao Huang, Lin Zhu, Zhi Zhu, Yanling Song*, Chaoyong Yang*. Tracing Tumor-derived Exosomal PD-L1 by Dual-aptamer Activated Proximity-induced Droplet Digital PCR. Angew. Chem. Int. Ed., 2021, 60, 7582–7586.

18. Lingling Wu, Yidi Wang, Xing Xu, Yilong Liu, Bingqian Lin, Mingxia Zhang, Jialu Zhang, Shuang Wan, Chaoyong Yang*, Weihong Tan*. Aptamer-Based Detection of Circulating Targets for Precision Medicine. Chem. Rev., 2021, 121, 12035–12105.

17. Mengjiao Huang^#, Tingyu Li^#, Yuanfeng Xu, Xinyu Wei, Jia Song, Bingqian Lin, Zhi Zhu, Yanling Song*, and Chaoyong James Yang*, Activation of Aptamers with Gain-of-Function by Small-MoleculeClipping of Intramolecular Motifs, Angew. Chem. Int. Ed. 2020, 60, 6021-6028.

16. Qingyu Ruan, Weidong Ruan, Xiaoye Lin, Yang Wang, Fenxiang Zou, Leiji Zhou, Zhi Zhu, Chaoyong Yang*, Digital-WGS: automated, highly efficient whole-genome sequencing of single cells by digital microfluidics, Sci. Adv., 2020, 6: eabd6454.

15. Liyuan Lin, Qiuyue Wu, Jia Song, Yahui Du, Juan Gao, Yanling Song, Wei Wang*, Chaoyong Yang*,Unveiling the Indigenous Growth and Division Patterns of Bacteria in Gut Microbiota, Sci. Adv., 2020, 6 : eabb2531.

14. Wei Wang*^#, Ni Zhang^#, Yahui Du^#, Juan Gao, Min Li, Liyuan Lin, Daniel M. Czajkowsky, Xiaowei Li*, Chaoyong Yang*, Zhifeng Shao. Three-dimensional Quantitative Imaging of Native Microbiota Distribution in the Gut. Angew. Chem. Int. Ed., 2021, 60, 3055-3061.

13. Jialu Zhang, Bingqian Lin, Lingling Wu, Mengjiao Huang, Xingrui Li, Huimin Zhang, Jia Song, Wei Wang, Gang Zhao,* Yanling Song,* and Chaoyong Yang*, DNA Nanolithography Enables Highly Ordered Recognition Interface in Microfluidic Chip for Efficient Capture and Release of Circulating Tumor Cells, Angew. Chem. Int. Ed., 2020, 59, 14115-14119.

12. Liyuan Lin, Jia Song, Yahui Du, Qiuyue Wu, Juan Gao, Yanling Song, Chaoyong Yang*, Wei Wang*, Quantification of Bacterial Metabolic Activities in the Gut by D-Amino Acid-based in vivo Labeling, Angew. Chem. Int. Ed., 2020, 59, 11923-11926.

11. Lingling Wu, Hongming Ding, Xin Qu, Xianai Shi, Jianmin Yang, Mengjiao Huang, Jialu Zhang, Huimin Zhang, Jia Song, Lin Zhu, Yanling Song*, Yuqiang Ma*, Chaoyong Yang*, Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability, J. Am. Chem. Soc. 2020, 142, 4800-4806.

10. Mengjiao Huang, Juanjuan Yang, Teng Wang, Jia Song, Jinglu Xia, Lingling Wu, Wei Wang, Qiaoyi Wu, Zhi Zhu, Yanling Song*, Chaoyong Yang*, Homogeneous, Low-volume, Efficient and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction. Angew. Chem. Int. Ed. 2020, 59, 4800-4805.

9. Mingxia Zhang, Yuan Zou, Xing Xu, Xuebing Zhang, Mingxuan Gao, Jia Song, Peifeng Huang, Qin Chen, Zhi Zhu, Wei Lin, Richard N. Zare, Chaoyong Yang*, Highly Parallel and Efficient Single Cell mRNA Sequencing with Paired Picoliter Chambers, Nat. Commun., 2020, 11, 2118. 

8. Wei Wang, Liyuan Lin, Yahui Du, Yanling Song, Xiaoman Peng, Xing Chen, Chaoyong James Yang. Assessing the Viability of Transplanted Gut Microbiotas by Sequential Tagging with D-Amino acid-based Metabolic Probes. Nat. Commun., 2019, 10(1): 1317.

7. Yansheng Li, Yanli Ma, Xiangyu Jiao, Tingyu Li, Zhehao Lv, Chaoyong James Yang, Xueji Zhang Yongqiang Wen. Control of capillary behavior through target-responsive hydrogel permeability alteration for sensitive visual quantitative detection. Nat. Commun., 2019, 10, 1036.

6.Wei Wang, Qinglai Yang, Yahui Du, Xiaobo Zhou, Xiaochen Du, Qiuyue Wu,  Liyuan Lin, Yanling Song, Fuyou Li, Chaoyong Yang*; Weihong Tan*. Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables in vivo Imaging of Gut Microbiota. Angew. Chem. Int. Ed., 2020, 59, 2628-2633.

5. Yanling Song, Yuanzhi Shi, Mengjiao Huang, Wei Wang, Yang Wang, Jie Cheng, Zhichao Lei, Zhi Zhu, Chaoyong Yang   Bioinspired Engineering of a Multivalent Aptamer-Functionalized Nanointerface to Enhance Capture and Release of Circulating Tumor Cells. Angew. Chem. Int. Ed. 2019, 58, 2236-2240.

4. Yahong Chen, Guoliang Ke, Yanli Ma, Zhi Zhu, Minghui Liu, Yan Liu, Hao Yan and Chaoyong James Yang. A Synthetic Light-Driven Substrate Channeling System for Precise Regulation of EnzymeCascade Activity Based on DNA Origami. J. Am. Chem. Soc. 2018, 140, 8990–8996.

3. Ahmed, M. G.; Abate, M. F.; Song, Y.; Zhu, Z.; Yan, F.; Xu, Y.; Wang, X.; Li, Q.; Yang, C.*. Isolation, Detection and Antigen Based Profiling of Circulating Tumor Cells Using a Size Dictated Immunocapture Chip. Angew. Chem. Int. Ed., 2017, 56, 10681-10685.

2. Zhu, Z.; Yang,C.*. Hydrogel Droplet Microfluidics for High-Throughput Single Molecule/Cell Analysis. Acc. Chem. Res., 2017, 50, 22–31.

1. Guoliang Ke, Minghui Liu, Shuoxing Jiang, Xiaodong Qi, Yuhe Renee Yang, Shaun Wootten, Fei Zhang, Zhi Zhu*; Yan Liu, Chaoyong Yang*, Hao Yan*, Directional Regulation of Enzyme Pathways via the Control of Substrate Channeling on a DNA Origami Scaffold. Angew Chem Int Ed, 2016, 55, 7483-7486.