Professor Yang
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Professor
Department of Chemical Biology, Xiamen University
Contact Information
Yang's LaboratoryRoom 532, Lujiaxi Building, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
Ph: +86 (0) 592-218 7601cyyang@xmu.edu.cn
Selection of Aptamers
Aptamer: CoV2- RBD-1C and CoV2-RBD-4C
Target: SARS-CoV-2 RBD
Kd: CoV2- RBD-1C and CoV2-RBD-4C aptamers against RBD were 5.8 nM± 0.8 nM and 19.9 nM± 2.6 nM, respectively.
Sequence: CoV2-RBD-1C aptamer ( 5'- CAGCACCGACCTTGTGCTTTGGGAGTGCT-GGTCCAAGGGCGTTAATGGACA-3') and CoV2-RBD-4C (5’-ATCCAGAGTGACG-CAGCATTTCATCGGGTCCAAAAGGGGCTGCTCGGGATTGCGGATATGGACACGT-3’).
Reference: Anal. Chem. 2020.
Aptamer: ZY5C
Target: cell surface vimentin (CSV)
Kd: 38 ± 4 nM (against CSV-positive T24 cells)
Sequence: 5′-CACGCATAGCCTTTGCTCCTCGTCTGGAACGTCGCAGCTTTAGTTC-TGGGCCTATGCGTG-3'
Reference: Anal. Chem. 2020, 92, 5178-5184.